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186763-78-0

中文名稱 人參皂苷 RG5
英文名稱 Ginsenoside-Rg5
CAS 186763-78-0
分子式 C42H70O12
分子量 767
MOL 文件 186763-78-0.mol
更新日期 2024/12/20 18:42:51
186763-78-0 結(jié)構(gòu)式 186763-78-0 結(jié)構(gòu)式

基本信息

中文別名
人參皂甙 RG5
人參皂苷 RG5
人參皂苷RG5對(duì)照品
人參皂苷RG5標(biāo)準(zhǔn)品
人參皂苷RG5, 來源于人參
人參皂甙 RG5?, >99%
英文別名
Ginsenoside-Rg5
Ginsenoside Rg5, >99%
Ginsenoside Rg5, 98%, from Panax ginseng C. A. Mey.
β-D-Glucopyranoside, (3β,12β,20E)-12-hydroxydammara-20(22),24-dien-3-yl 2-O-β-D-glucopyranosyl-
b-D-Glucopyranoside, (3b,12b,20E)-12-hydroxydammara-20(22),24-dien-3-yl 2-O-b-D-glucopyranosyl-
(3beta,12beta,20E)-12-Hydroxydammara-20(22),24-dien-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
(8ξ,9ξ,12α,13ξ,14β,17β)-12-Hydroxy-4,4,7,10,14-pentamethyl-17-[(2 E)-6-methyl-2,5-heptadien-2-yl]gonan-3-yl 2-O-β-D-glucopyranosyl- β-D-glucopyranoside
所屬類別
生物化工:植物提取物

物理化學(xué)性質(zhì)

外觀性狀白色結(jié)晶粉末,可溶于甲醇、乙醇、DMSO等有機(jī)溶劑,來源于人參。
沸點(diǎn)855.6±65.0 °C(Predicted)
密度1.28±0.1 g/cm3 (20 ºC 760 Torr)
儲(chǔ)存條件2-8°C
溶解度Soluble in DMSO; sparingly soluble in methanol;
酸度系數(shù)(pKa)12.85±0.70(Predicted)
形態(tài)粉末
顏色白色
水溶解性不溶于水
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安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302

應(yīng)用領(lǐng)域

用途1
用于含量測(cè)定/鑒定/藥理實(shí)驗(yàn)等
用途2
人參皂苷Rg5是蒸參中提取的主要成分,具有抗炎癥作用。

常見問題列表

簡(jiǎn)介

人參皂苷 RG5提取自蒸參,可用于含量測(cè)定/鑒定/藥理實(shí)驗(yàn)等。

生物活性
Ginsenoside Rg5 是紅參的主要成分。Ginsenoside Rg5 阻斷 IGF-1 與其受體的結(jié)合,IC50 約為90 nM。Ginsenoside Rg5 還通過抑制 NF-κB p65 的 DNA 結(jié)合活性來抑制 COX-2 的 mRNA 表達(dá)。
靶點(diǎn)

p65

COX-2

IGF-1R

90 nM (IC 50 )

體外研究

Ginsenoside Rg5 plays a novel role as an IGF-1R agonist. Ginsenoside Rg5 binds to IGF-1R with an IC 50 value of ~90 and its angiogenic activity is inhibited by IGF-1R knockdown. To investigate the possible interaction of Ginsenoside Rg5 with IGF-1R, a docking analysis is performed. Docking results show that Ginsenoside Rg5 binds strongly at two sites, A and B, with K d values of 20 and 27 nM, respectively, to the cysteine-rich domain of IGF-1R. Pretreatment with Rg5 blocks the binding of radiolabeled IGF-1 to HUVECs with an IC 50 value of ~90 μM, which is greater than an IC 50 value of ~1.4 nM for unlabeled IGF-1. The results from MTT assay show that MCF-7 cell proliferation is inhibited by Ginsenoside Rg5 treatment for 24, 48 and 72 h in a dose-dependent manner. Ginsenoside Rg5 at different concentrations (0, 25, 50 and 100 μM), induce cell cycle arrest in G0/G1 phase through regulation of cell cycle-related proteins in MCF-7 cells.

體內(nèi)研究

Ginsenoside Rg5 inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65 in lipopolysaccharides (LPS)-stimulated BV2 microglial cells. Rg5 pretreated group mice show declined expression of NF-κB p65 and COX-2. In the group treated with low dose of Ginsenoside Rg5 (10 mg/kg), there is remarkable tubular damage and infiltration of inflammatory cells. However, at the higher dose of Ginsenoside Rg5 (20 mg/kg), tubules markedly appeare histologically normal and no inflammation and cast formation is observed in kidney tissues.

人參皂苷 RG5價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-N0908人參皂苷 RG5
Ginsenoside Rg5
186763-78-05mg2800元
2024/11/08HY-N0908人參皂苷 RG5
Ginsenoside Rg5
186763-78-010mM * 1mLin DMSO3797元
2024/11/08HY-N0908人參皂苷 RG5
Ginsenoside Rg5
186763-78-010mg4500元
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