143797-62-0
143797-62-0 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-103129 | 1-(1-甲基-1H-吲哚-5-基)-3-(吡啶-3-基)脲鹽酸鹽 SB-200646A | 143797-62-0 | 5mg | 700元 |
| 2024/11/08 | HY-103129 | 1-(1-甲基-1H-吲哚-5-基)-3-(吡啶-3-基)脲鹽酸鹽 SB-200646A | 143797-62-0 | 10mM * 1mLin DMSO | 770元 |
| 2024/11/08 | HY-103129 | 1-(1-甲基-1H-吲哚-5-基)-3-(吡啶-3-基)脲鹽酸鹽 SB-200646A | 143797-62-0 | 10mg | 1100元 |
常見問題列表
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5-HT 2B Receptor 7.5 (pKi) |
5-HT 2C Receptor 6.9 (pKi) |
5-HT 2A Receptor 5.2 (pKi) |
SB200646A (4 μM) abolishes the ethanol-induced increase in miniature inhibitory postsynaptic current (mIPSC) frequency and had no effect on basal mIPSC frequency.
SB-200646A (20 mg/kg; intravenous injection; daily; for 21 days; male albino Sprague-Dawley rats) treatment significantly decreases the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons.
The i.v. administration of 4-16 mg/kg of SB-200646A significantly increases the firing rate and % events as bursts in spontaneously active VTA dopaminergic neurons and significantly increases the % events as burst in substantia nigra pars compacta (SNC) dopaminergic neurons.
| Animal Model: | Male albino Sprague-Dawley rats (200-225 g at the beginning of treatment and 300-350 g at the time of the experiment) |
| Dosage: | 20 mg/kg |
| Administration: | Intravenous injection; daily; for 21 days |
| Result: | Significantly decreased the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons. |