140-79-4
140-79-4 結(jié)構(gòu)式
基本信息
哌嗪雜質(zhì)24
N,N-二硝基哌嗪
標(biāo)準(zhǔn)品RN1031
N,N-二亞硝基哌嗪
1,4-二亞硝基哌嗪
哌柏西利雜質(zhì)IM-065
1,4-二亞硝哌【口+井】
Dinitrosopiperazine
Dnpz
nsc339
NSC 339
usafdo-36
USAF do-36
Dinitrosopiperazin
TIMTEC-BB SBB008187
Piperazine Impurity 4
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-136433 | 1,4-二亞硝哌【口+井】 N,N'-Dinitrosopiperazine | 140-79-4 | 5 mg | 600元 |
| 2024/11/08 | HY-136433 | 1,4-二亞硝哌【口+井】 N,N'-Dinitrosopiperazine | 140-79-4 | 10 mg | 950元 |
| 2024/11/08 | HY-136433 | 1,4-二亞硝哌【口+井】 N,N'-Dinitrosopiperazine | 140-79-4 | 25 mg | 1900元 |
常見(jiàn)問(wèn)題列表
N,N'-Dinitrosopiperazine (0.5-100 μM; 48 hours) has no inhibitory effects on the labeled 6-10B cells, and LDH activity is not significantly altered by DNP treatment in the 0.5-8?μM concentration range. However, it is cytotoxic from the concentration 10 μM.N,N'-Dinitrosopiperazine (2-8 μM; 24 hours) induces 6-10B cell invasion and motility in a dose-dependent manner. At 6?μM, when compares to the control group, DNP increases cell invasion at 421.7% and cell motility is increased by 328.2%.N,N'-Dinitrosopiperazine (6 μM; 24 hours) increases the expression of phospho-LYRIC s568 and LYRIC expression in CNE1 cells.
Cell Viability Assay
| Cell Line: | The labeled 6-10B cells |
| Concentration: | 0.5, 1, 2, 4, 6, 8, 10, 20, 40, 80, or 100?μM |
| Incubation Time: | 48 hours |
| Result: | Had no inhibitory effects at the concentration 0-8?μM. |
Western Blot Analysis
| Cell Line: | The?NPC cell line CNE1 |
| Concentration: | 6?μM |
| Incubation Time: | 24 hours |
| Result: | Increased phospho-LYRIC s568 and LYRIC expression. |
N,N'-Dinitrosopiperazine (injected into the tail veins; 40 mg/kg; 30 days) inhibits cell motility and invasion, and facilitates NPC metastasis in vivo. From a IHC result, Phospho-LYRIC expression is higher in the metastatic tumors of DNP-treated mice than in those of the untreated control mice.
| Animal Model: | BABL/c nude mice injected with labeled 6-10B cell suspensions (1?×?10 4 cells) with or without DNP(40 mg/kg) |
| Dosage: | 40 mg/kg |
| Administration: | Injected into the tail veins; 30 days |
| Result: | Induced LYRIC phosphorylation at serine 568 associated with NPC metastasis in vivo. |