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121584-18-7

中文名稱 伐司撲達(dá)
英文名稱 Valspodar
CAS 121584-18-7
分子式 C63H111N11O12
分子量 1214.62
MOL 文件 121584-18-7.mol
更新日期 2024/12/16 15:20:15
121584-18-7 結(jié)構(gòu)式 121584-18-7 結(jié)構(gòu)式

基本信息

中文別名
戊司泊達(dá)
伐司撲達(dá)
伐司樸達(dá)
P-糖蛋白抑制劑(VALSPODAR)
英文別名
CS-51
AMdray
Psc 833
Valpodar
Valspodar
Sdz-psc-833
Sdz psc 833
Valspodar, >=98%
PSC833(Valspodar)
Valspodar (PSC-833)
所屬類別
生物化工:激動劑抑制劑

物理化學(xué)性質(zhì)

熔點(diǎn)143-145°C
比旋光度D20 -255.1° (c = 0.5 in CHCl3)
沸點(diǎn)1290.1±65.0 °C(Predicted)
密度1.015±0.06 g/cm3(Predicted)
儲存條件-20°C
溶解度可溶于氯仿(少許)、甲醇(少許)
酸度系數(shù)(pKa)12.45±0.70(Predicted)
形態(tài)粉末
顏色白色至米色
InChIKeyYJDYDFNKCBANTM-QCWCSKBGSA-N

安全數(shù)據(jù)

WGK Germany3
伐司撲達(dá)價(jià)格(試劑級)
報(bào)價(jià)日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價(jià)格
2024/11/08HY-17384伐司撲達(dá)
Valspodar
121584-18-71mg3500元
2023/03/20HY-17384伐司撲達(dá)
Valspodar
121584-18-75mg11200元
2022/09/18HY-17384伐司撲達(dá)
Valspodar
121584-18-710 mg8650元

常見問題列表

生物活性
Valspodar (PSC 833) 是一種選擇性的 P-糖蛋白抑制劑,已被用作化學(xué)增敏劑用于實(shí)驗(yàn)性癌癥的研究。
體外研究

Valspodar (PSC 833) has no cytotoxicity effects at up to the concentration of 0.75 μg/mL. Valspodar (0.25, 0.5 and 0.75 μg/mL) and DOX-L are added to the DOX resistant cells, and cell kill efficacy of MDR cell type increases significantly when valspodar is administered alongside DOX-L. Valspodar (0.5 and 0.75 μg/mL), in combination with all concentrations of DOX, are most toxic and kill more than 70% of the resistant cells. Pretreatment with PSC833 decreases the IC 50 value of NSC 279836 in MDA-MB-435mdr cells to 0.4±0.02 μM in MDR cells and almost completely reverses the resistance of MDR cells to NSC 279836.

體內(nèi)研究

valspodar (10 mg/kg, o.p.) exhibits minimal blood-cell partitioning as reflected in its low mean blood-to-plasma ratio of approximately 0.52. Valspodar displays properties of slow clearance and a large volume of distribution. Valspodar shows properties of low hepatic extraction and wide distribution, similar to that of its structural analogue CsA. Preadministration of PSC833 to mice increases NSC 279836 fluorescent intensity in MDR tumor to 94% of that in the wild-type tumors.

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