1184136-10-4
中文名稱
UNC-926
CAS
1184136-10-4
分子式
C16H21BrN2O
分子量
337.25
MOL 文件
1184136-10-4.mol
更新日期
2024/12/15 19:35:15
1184136-10-4 結(jié)構(gòu)式
基本信息
中文別名
化合物UNC 926 HYDROCHLORIDE 英文別名
UNC-926UNC-926 Hydochloride
UNC-926 Hydrochloride
UNC926
UNC-926
UNC 926
(3-bromophenyl)-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone
(3-Bromophenyl)[4-(1-pyrrolidinyl)-1-piperidinyl]-methanone
Methanone, (3-bromophenyl)[4-(1-pyrrolidinyl)-1-piperidinyl]-
(3-Bromophenyl)[4-(1-prrolidinyl)-1-piperidinyl]methanone hydrochloride
應(yīng)用領(lǐng)域
用途1
UNC-926 is a methyl-lysine reader antagonist; binds to the MBT domain of the L3MBTL1 protein (Kd = 3.9 渭M). UNC-926 selectively inhibits the interaction between L3MBTL13XMBT-H4K20me1 in a peptide pull
down assay.常見問題列表
生物活性
UNC926 是一種 methyl-lysine (Kme) reader domain 抑制劑，可特異性抑制 L3MBTL1，其 IC50 為 3.9 μM。靶點(diǎn)
| Target | Value |
|
L3MBTL1
() | 3.9 μM(Kd) |
體外研究
UNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC
50
of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7.
UNC926 (1-25 μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a dose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1.