102396-24-7
中文名稱
JASPLAKINOLIDE
英文名稱
JASPLAKINOLIDE
CAS
102396-24-7
分子式
C36H45BrN4O6
分子量
709.67
MOL 文件
102396-24-7.mol
102396-24-7 結(jié)構(gòu)式
基本信息
中文別名
茉莉花內(nèi)酯JASPLAKINOLIDE 試劑
英文別名
NSC 613009JASPLAKINOLIDE
GQWYWHOHRVVHAP-DHKPLNAMSA-N
JASPLAKINOLIDE, JASPIS JOHNSTONI
Jasplakinolide, Jaspis johnstoni - CAS 102396-24-7 - Calbiochem
Cyclo[(3R)-3-(4-hydroxyphenyl)-β-alanyl-(2S,4E,6R,8S)-8-hydroxy-2,4,6-trimethyl-4-nonenoyl-L-alanyl-2-bromo-N-methyl-D-tryptophyl]
(3S,6R,9R,13S,15R,16E,19S)-3,5,13,15,17,19-Hexamethyl-6-[(2-bromo-1H-indole-3-yl)methyl]-9-(4-hydroxyphenyl)-12-oxa-2,5,8-triazacyclononadeca-16-ene-1,4,7,11-tetraone
[3S,6R,9R,13S,15R,19S,16E,(+)]-6-[(2-Bromo-1H-indol-3-yl)methyl]-9-(4-hydroxyphenyl)-3,5,13,15,17,19-hexamethyl-2,5,8-triaza-12-oxacyclononadecan-16-ene-1,4,7,11-tetrone
常見(jiàn)問(wèn)題列表
生物活性
Jasplakinolide 是一種有效的肌動(dòng)蛋白聚合反應(yīng) (actin polymerization) 誘導(dǎo)劑，可以穩(wěn)定先前存在的肌動(dòng)蛋白絲。Jasplakinolide 與鬼筆環(huán)肽競(jìng)爭(zhēng)性結(jié)合 F-肌動(dòng)蛋白，Kd 值為 15 nM。Jasplakinolide 是一種來(lái)自海洋海綿 (marine sponge) 的天然環(huán)狀肽，具有抗真菌和抗腫瘤活性。體外研究
Jasplakinolide has an IC
50
of 35 nM for the antiproliferative effect of jasplakinolide on PC3 prostate carcinoma cells.
Jasplakinolide (10 μM; for 2 hours) generates binucleated cells when applied during mitosis. Jasplakinolide induces the formation of F-actin-containing apical extensions in Toxoplasma gondii tachyzoites.
Jasplakinolide (1 mM; for 60 min) induces the formation of actin-containing apical extensions in isolated Toxoplasma gondii tachyzoites fixed.