| Identification | More | [Name]
Methyl nicotinate | [CAS]
93-60-7 | [Synonyms]
3-CARBOXYPYRIDINE METHYL ESTER
3-PYRIDINECARBOXYLIC ACID METHYL ESTER
AKOS BBS-00004415
FEMA 3709
METHYL 3-PYRIDINECARBOXYLATE
METHYL NICOTINATE
METHYL NICOTINATE DAC
METHYL PYRIDINE-3-CARBOXYLATE
NIACIN METHYL ESTER
NICONACID METHYL ESTER
NICOTINIC ACID METHYL ESTER
PELLAGRA PREVENTIVE FACTOR METHYL ESTER
PYRIDINE-3-CARBOXYLIC ACID METHYL ESTER
RARECHEM AL BF 0185
3-(carbomethoxy)pyridine
3-(Methoxycarbonyl)pyridine
3-Carbomethoxypyridine
m-(methoxycarbonyl)pyridine
Methyl ester of pyridine-3-carboxylic acid
methylnicotinicacid | [EINECS(EC#)]
202-261-8 | [Molecular Formula]
C7H7NO2 | [MDL Number]
MFCD00006388 | [Molecular Weight]
137.14 | [MOL File]
93-60-7.mol |
| Chemical Properties | Back Directory | [Appearance]
white to brownish crystals or crystalline powder | [Melting point ]
42-44 °C (lit.) | [Boiling point ]
204 °C (lit.) | [density ]
1.2528 (rough estimate) | [vapor pressure ]
0.4 hPa (25 °C) | [FEMA ]
3709 | [refractive index ]
1.5323 (estimate) | [Fp ]
204 °F
| [storage temp. ]
Store below +30°C. | [solubility ]
H2O: 0.1 g/mL, clear
| [form ]
Crystals or Crystalline Powder | [pka]
pKa 3.1 (Uncertain) | [color ]
White to brownish | [Odor]
at 10.00 % in dipropylene glycol. warm herbal tobacco | [Odor Type]
herbal | [Water Solubility ]
NEGLIGIBLE | [Detection Methods]
GC,NMR | [JECFA Number]
1320 | [Merck ]
14,6100 | [BRN ]
113951 | [InChIKey]
YNBADRVTZLEFNH-UHFFFAOYSA-N | [LogP]
0.68 at 25℃ | [Uses]
Vasodilator. | [CAS DataBase Reference]
93-60-7(CAS DataBase Reference) | [NIST Chemistry Reference]
Methyl nicotinate(93-60-7) | [EPA Substance Registry System]
93-60-7(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R36/38:Irritating to eyes and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [RTECS ]
QT1925000
| [TSCA ]
Yes | [HS Code ]
29333999 | [Toxicity]
LD50 orally in Rabbit: > 2000 mg/kg |
| Hazard Information | Back Directory | [Description]
Methyl nicotinate has a fresh, sweet, caramellic nutty odor. | [Chemical Properties]
Methyl nicotinate has a fresh, caramellic, nutty and mild tobacco odor. | [Chemical Properties]
white to brownish crystals or crystalline powder | [Occurrence]
Reported found in ground coffee, roasted filberts, guanabana (Annona muicata L.), roasted peanuts, wild
strawberries, vanilla bean, papaya, guava, plum, beer cognac, soursop, malt, wort, Bourbon vanilla and mountain papaya. | [Application]
Methyl nicotinate can be employed as a precursor in the synthesis:
Di-3-pyridyl ketone ligand, which is used in the preparation of silver(I) complexes for the derivation of coordination polymeric chains.
5-arylnicotinates , ±-sesbanine , and 1,4-dihydropyridine derivatives. | [Definition]
ChEBI: Methyl nicotinate is a member of pyridines and an aromatic carboxylic acid. | [Preparation]
Methyl nicotinate was prepared by esterification of nicotinic acid by refluxing with methanol in the presence of concentrated sulphuric acid, esterification product obtained was extracted into organic solvent (chloroform) after neutralization of the reaction mixture with 10% sodium bicarbonate.
Synthesis and antinociceptive activity of methyl nicotinate
DOI:10.4314/jpb.v12i1.8 | [General Description]
Methyl nicotinate (or nicotinic acid methyl ester) is used as a rubefacient for the relief of pains in muscles, tendons, and joints. It is also used in food as a flavoring agent. | [Side effects]
There is presently no side effect information available for Methyl nicotinate(MN) itself. a few patients who applied a medicated topical preparation containing MN (and other components) suffered adverse reactions including faintness, nausea, pain and skin rashes. | [Safety]
No data are available for chronic toxicity of Methyl nicotinate(MN) in humans. No adverse effects were reported for nicotinamide in clinical studies, whereas high doses of NA (3000 mg/day) are associated with considerable toxicity. In one third to one half of the 1119 patients taking 3000 mg NA /day for at least five years (to reduce the incidence of a second myocardial infarction), side effects included gastrointestinal and urinary tract problems, as well as dermatological problems of flushing, itching and rash ("The Coronary Drug Project", 1975, cited in "monograph of methyl nicotinate", Council of Europe, 2008, pp. 248). | [Synthesis]
Methyl nicotinate is synthesized from Nicotinyl chloride hydrochloride and and Methanol in presence of Pyridine.
| [Carcinogenicity]
No data on the mutagenic or carcinogenic potential of methyl nicotinate were presented. However life-time studies in mice employing doses of 2 to 3 mg nicotinamide/kg bw/day gave no indication of carcinogenic potential. | [storage]
Store at -20°C |
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