| Identification | More | [Name]
Acid Blue 74 | [CAS]
860-22-0 | [Synonyms]
5,5-INDIGO DISULFONIC ACID
5,5'-INDIGODISULFONIC ACID DISODIUM SALT
ACID BLUE 74
BLUE ACID 74
CARMINE BLUE
CI 73015
CI NO 73015
Disodium 5,5'-(2-(1,3-dihydro-3-oxo-2H-indazol-2-ylidene)-1,2-dihydro-3H-indol-3-one)disulphonate
E132
FD AND C BLUE 2
FD AND C BLUE NO 2
FDC BLUE NO 2
food blue 1
FOOD BLUE NO 2
INDIGO-5,5'-DISULFONIC ACID DISODIUM SALT
INDIGO CARMINE
INDIGO DISULFONATE
INDIGOTINE
INDIGOTINE 1
INDIGOTINE 1A | [EINECS(EC#)]
212-728-8 | [Molecular Formula]
C16H8N2Na2O8S2 | [MDL Number]
MFCD00005723 | [Molecular Weight]
466.35 | [MOL File]
860-22-0.mol |
| Chemical Properties | Back Directory | [Appearance]
purple powder | [Melting point ]
>300°C | [density ]
1.01 g/mL at 20 °C | [refractive index ]
n20/D 1.335 | [storage temp. ]
room temp | [solubility ]
1g/l | [Colour Index ]
73015 | [form ]
Powder/Solid | [color ]
Very dark blue to purple | [Odor]
Light odour | [PH]
7 (10g/l, H2O, 20℃) | [PH Range]
11.5(blue)-14.0(yellow) | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
1 g/100 mL (25 ºC) | [Sensitive ]
Light Sensitive | [λmax]
608nm | [Merck ]
14,4944 | [BRN ]
4103904 | [Biological Applications]
Detecting microorganisms; treating amyloidosis,testicular cancer; medical devices; drug delivery system | [Major Application]
Display device, sensor, chemical-mechanical polishing, batteries, photographic materials, thermoplastics, inks, highlighters, detergents, disinfectants, rodenticide, colored bubbles, hair dyes, cosmetics, food, determine bacterial growth, antiischemic Magents, antiseptic, antitumor agents, Alzheimer’s disease, psychoactive drugs, Tooth whitening | [Uses]
Indigo Carmine (FD&C Blue #2) is a colorant. It has poor ph stability in that after 1 week at ph 3 and 5 it will appreciably fade, at ph 7 considerably fade, and at ph 8 fade completely. It is the least soluble of all food colors, with a solubility of 1.6 g in 100 ml of water at 25°c. Complete fading occurs in alkalis such as 10% sodium carbonate and 10% sodium hydroxide, with fading also occurring in 10% sugar systems. It has very poor light stability and oxidation stability, and moderate stability to heat; it has a deep blue hue with poor tinctorial strength. It is the only food color that has good resistance to reducing agents, but has very poor compatibility with food components. The major use is in pet food, but it is also used in candies, confections, and baked goods. The common name is indigotine. | [CAS DataBase Reference]
860-22-0(CAS DataBase Reference) | [EPA Substance Registry System]
860-22-0(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S27:Take off immediately all contaminated clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [RTECS ]
DU3000000
| [TSCA ]
Yes | [HS Code ]
32041200 | [Hazardous Substances Data]
860-22-0(Hazardous Substances Data) | [Toxicity]
LD50 orally in Rabbit: > 2000 mg/kg |
| Hazard Information | Back Directory | [General Description]
Indigo to dark blue powder. | [Reactivity Profile]
Sensitive to light. Very sensitive to oxidizing agents. Color is readily discharged by nitric acid, chlorates, etc. Color of aqueous solutions fades on standing. | [Air & Water Reactions]
Water soluble. | [Fire Hazard]
Flash point data for this compound is not available, but INDIGO CARMINE is probably combustible. | [Description]
Indigo carmine is indigotindisulfonate sodium, a marker dye used during cystoscopy and ureteral catheterization.
(1) Indigo carmine is also used in endoscopic procedures, lymph node and vessel delineation, and for tumor localization. Indigo carmine is an unapproved drug without FDA approved labeling.
(2) There is no single dye that can replace indigo carmine. Choice of alternative agent will depend on type of procedure and physician discretion, as well as product availability.
Indigo Carmine (IC) is the most common chemical dye for clothes dyeing, which is considered as a refractory molecule since it is required a rather strong chemical treatment for its elimination from the water waste. The presence of this dye in residuals causes notorious change of water color and smell even in very low concentration. Moreover, if some of this water reaches natural streams it can be toxic for aquatic living entities due to the formation of toxic compounds such as aromatic amines. | [Chemical Properties]
FD & C Blue No. 2 is principally the disodium salt of 2-( 1,3-dihydro-3-oxo-5-sulfo-2H-indol-2-ylidene)-2,3-dihydro3-oxo-lH-indole-5-sulfonic acid.
The colorant is a blue-brown to red-brown powder that dissolves in water to give a solution that is blue at neutrality, blue-violet in acid, and green to yellow-green in base. When dissolved in concentrated sulfuric acid, it yields a blue-violet solution that turns blue when diluted with water. It is soluble in 95% ethanol.
FD & C Blue No. 2 is used in dessert powders, bakery goods, cereals, snack foods, confectionery products, maraschino cherries, sausage, ice cream, sherbet, and dairy products. The color is also used in drug preparations.1
. | [Chemical Properties]
purple powder | [Definition]
ChEBI: An organic sodium salt resulting from the formal condensation of indigo carmine (acid form) with two equivalents of sodium hydroxide. It is an indicator at pH 11.5-14, changing from blue to yellow. | [Preparation]
3H-indol-3-one,2-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,2-dihydro?with strong sulfuric acid or trace fuming sulfuric acid products. | [Brand name]
Indigo Carmine (Becton Dickinson Microbiology). | [Biochem/physiol Actions]
Indigo Carmine (IC), commonly known as acid blue 74 or food blue 1 or FD and C blue 2 is a blue synthetic dye. It is used as a redox indicator in analytical chemistry and as a microscopic stain in biology. IC is also employed as a photometric detector. IC is a highly toxic indigoid dye and is associated with various health hazards such as irritation to the gastrointestinal tract leading to nausea, vomiting, and diarrhea and irritation in the respiratory tract leading to coughing and shortness of breath. IC exposure might also cause skin and eye irritations to humans. IC dye spray is used for the diagnosis of dysplasia in ulcerative colitis and is considered to be a simple, feasible, and safe method. | [Properties and Applications]
green light blue. Soluble in water for blue, slightly soluble in alcohol. The strong sulfuric acid is a deep blue light in purple, diluted into blue. In aqueous solution for green to yellow sodium hydroxide to join.
|
Standard
|
Light Fastness
|
Soaping
|
Persperation Fastness
|
Oxygen bleaching
|
Fastness to seawater
|
|
Fading
|
Stain
|
Fading
|
Stain
|
Fading
|
Stain
|
|
ISO
|
1-2
|
2
|
4
|
2
|
1
|
2
|
2
|
1
|
|
AATCC
|
1
|
3
|
5
|
1
|
1
|
1
|
2
|
2
|
| [Purification Methods]
Its solubility in H2O is 1g/100mL at 25o. It has been purified by dissolving in H2O, filtering and adding EtOH to cause the salt to separate. Wash the solid with EtOH, Et2O and dry in vacuo. [V.rlander & Schubert Chem Ber 34 1860 1901, UV: Smit et al. Anal Chem 27 1159 1955, Preisler et al. J Am Chem Soc 81 1991 1959, Beilstein 25 IV 1975.] | [References]
American Society of Health-system Pharmacist.
Journal of Environmental Protection, 2016, 7, 1693-1706 |
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