| Identification | More | [Name]
Benzhydrylpiperazine | [CAS]
841-77-0 | [Synonyms]
1-BENZHYDRYLPIPERAZINE
1-BENZYHYDRYLPIPERAZINE
1-(DIPHENYLMETHYL)PIPERAZINE
AKOS BBS-00003601
AKOS NCG1-0108
BENZHYDRYLPIPERAZINE
LABOTEST-BB LT00454383
N-BENZHYDRYLPIPERAZINE
N-BENZYLHYDRYLPIPERAZINE
TIMTEC-BB SBB003136
1-(diphenylmethyl)-piperazin
4-benzhydrylpiperazine
Diphenylmethylpiperazine
N-(Diphenylmethyl)piperazine
norcyclizine
1-Benzhydrylpiperazine 97%
1-Benzhydrylpiperazine ,99% | [EINECS(EC#)]
212-667-7 | [Molecular Formula]
C17H20N2 | [MDL Number]
MFCD00038379 | [Molecular Weight]
252.35 | [MOL File]
841-77-0.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystalline powder | [Melting point ]
90-93 °C | [Boiling point ]
185°C/2mmHg(lit.) | [density ]
1.0546 (rough estimate) | [vapor pressure ]
0.001Pa at 20℃ | [refractive index ]
1.5794 (estimate) | [Fp ]
115 °C
| [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
Methanol (Slightly) | [form ]
Crystalline Powder | [pka]
9.05±0.10(Predicted) | [color ]
White to light yellow | [Water Solubility ]
0.45 g/L (20 ºC) | [Sensitive ]
Air Sensitive | [Detection Methods]
NMR | [BRN ]
222773 | [LogP]
0.6 at 20℃ | [CAS DataBase Reference]
841-77-0(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzhydryl piperazine(841-77-0) | [Storage Precautions]
Air sensitive |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [RTECS ]
TL6465000
| [F ]
34 | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystalline powder | [Uses]
1-(Diphenylmethyl)piperazine [N-(Diphenylmethyl)piperazine] may be used for the synthesis of 2-nitro-3,4,4-trichloro-1-(propylthio)-1-[4-(diphenylmethyl)piperazin-1-yl]-1,3-butadiene and 2-nitro-3,4,4-trichloro-1-(octadecylthio)-1-[4-(diphenylmethyl)piperazin-1-yl]-1,3-butadiene. | [Uses]
1-Benzhydrylpiperazine is an intermediate used in drug synthesis
| [Uses]
Cinnarizine (C465300) impurity. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 77, p. 1098, 1955 DOI: 10.1021/ja01610a006 | [General Description]
1-(Diphenylmethyl)piperazine is an intermediate during drug synthesis. It has been reported to be formed during the oxidative metabolism of cinnarizine (CZ) [1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-piperazine] in rat liver microsomes. It reacts with quinone in acetonitrile, followed by oxidation with an alkaline potassium ferricyanide, to afford 4-amino-3,6-di(tert-butyl)-o-benzoquinones. | [Flammability and Explosibility]
Notclassified |
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