| Identification | More | [Name]
8-Hydroxyquinaldine | [CAS]
826-81-3 | [Synonyms]
2-METHYL-8-HYDROXYQUINOLINE
2-METHYL-8-QUINOLINOL
2-METHYLOXINE
8-HYDROXY-2-METHYLQUINOLINE
8-HYDROXYQUINALDINE
TIMTEC-BB SBB009099
2-methyl-8-quinolino
8-Hydroxyqinaldine
8-Quinolinol,2-methyl-
Hydroxyquinaldine
4-Hydroxy-3-quinoline carboxylic acid
8-Hydroxyquinaldine~2-Methyl-8-quinolinol
Hydroxyquinaldine,99%
8-HYDROXYQUINALDINE MIN. 98%
8-HYDROXYQUINALDINE 98%
1-Methyl 8-quinolinol
2-Methyl-8-hydroxy
2-Methylquinolin-8-ol | [EINECS(EC#)]
212-562-6 | [Molecular Formula]
C10H9NO | [MDL Number]
MFCD00006765 | [Molecular Weight]
159.18 | [MOL File]
826-81-3.mol |
| Safety Data | Back Directory | [Hazard Codes ]
N,Xi | [Risk Statements ]
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
UN 3077 9/PG 3
| [WGK Germany ]
2
| [RTECS ]
VC7920000
| [Hazard Note ]
Irritant | [TSCA ]
Yes | [HazardClass ]
9 | [PackingGroup ]
III | [HS Code ]
29334990 |
| Hazard Information | Back Directory | [Chemical Properties]
beige to brown crystalline powder | [Uses]
8-Hydroxy-2-methylquinoline is used as pharmaceutical intermediate. | [Definition]
ChEBI: 2-Methylquinolin-8-ol is a hydroxyquinoline. | [Preparation]
8-hydroxyquinaldine is obtained from the reaction of 2-aminophenol with crotonaldehyde. Mix 2-aminophenol and 2-Nitrophenol homogeneously and add hydrochloric acid. Add crotonaldehyde under stirring. Heat for 6h and leave overnight. Distill the reacted o-nitrophenol by water distillation, and add sodium hydroxide solution to the residual solution to make it weakly basic. Then add powdered carbonyls for saturation, and distill 8-Hydroxyquinaldine by water distillation, and then distill the crude product under reduced pressure and recrystallize it with ethanol to obtain 8-hydroxyquinaldine. | [Synthesis Reference(s)]
Tetrahedron, 52, p. 2937, 1996 DOI: 10.1016/0040-4020(95)01118-8 | [General Description]
2-Methyl-8-quinolinol is a methyl substituted quinolinol derivative that shows fungicidal property. It can also undergo complexation with transition metal complexes. | [Purification Methods]
Crystallise the quinoline from EtOH or aqueous EtOH. Its solubility at 20o in H2O is 0.366g/L, and in CHCl3 it is 466g/L. It complexes with many metals. [Beilstein 21 H 106, 21 III/IV 2132.] |
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