| Identification | More | [Name]
Mancozeb | [CAS]
8018-01-7 | [Synonyms]
((1,2-Ethanediylbis(carbamodithioato)))manganese mixture with ((1,2-ethandiylbis(carbamodithioate)))zinc
AIMCOZEB
CRITTOX
DITHANE
DITHANE(R)
FORE(R)
MANCO
MANCOZEB
MANCOZEB STANDARD
MANEX II
MANGANESE-ZINC ETHYLENEBIS(DITHIOCARBAMATE)
MANZATE(R)
MANZEB
MICENE
PENNCOZEB(R)
PENNFLUID(R)
TRIDEX(R) FUNGICIDE
TRIMANOC(R)
VONDOZEB
ZINC AND MANGANESE ETHYLENE-BISDITHIOCARBAMATE COORDINATION PRODUCT | [EINECS(EC#)]
616-995-5 | [Molecular Formula]
C4H8MnN2S4Zn | [MDL Number]
MFCD00078616 | [Molecular Weight]
332.71 | [MOL File]
8018-01-7.mol |
| Chemical Properties | Back Directory | [Appearance]
Grayish-yellow powder | [Melting point ]
192-194°C | [density ]
1.92 g/cm3 | [vapor pressure ]
Negligible at 20 °C | [Fp ]
138 °C | [storage temp. ]
APPROX 4°C
| [solubility ]
DMSO: 1 mg/mL (1.51 mM); Water: < 0.1 mg/mL (insoluble) | [form ]
Solid:particulate/powder | [Water Solubility ]
6-20 mgl-1 (20 °C) | [color ]
Light yellow to yellow | [Merck ]
13,5738 | [Contact allergens]
Mancozeb is a fungicide of the ethylene-bis-dithiocarbamate group. It is present in Rondo-M? with pyrifenox.Occupational exposure occurs mainly in agriculturalworkers, in vineyard workers, or in florists. | [LogP]
1.8-2.3 at 20℃ and pH6-10 | [Dissociation constant]
12.09 at 20℃ | [CAS DataBase Reference]
8018-01-7(CAS DataBase Reference) | [EPA Substance Registry System]
8018-01-7(EPA Substance) |
| Hazard Information | Back Directory | [Uses]
Mancozeb is a mixture of Maneb (M163500) and Zineb, a manganese and zinc (1:1) complex mixture with the ethylene bis(dithiocarbamate) anionic ligand. Mancozeb is a foliate fungicide used to protect cr
ops in agriculture. Mancozeb has a broader and more effective fungacidal activity than either of its component on their own. Mancozeb also significantly enhances the copper activity against several ba
cteriosis. | [Uses]
Fungicide. | [Potential Exposure]
Mancozeb is a dithiocarbamate fungicide. It is used to control a wide variety of fungal diseases,
including potato blight, leaf spot, scab (on apples and
pears), and rust (on roses). It is used on fruits, vegetables,
nuts and field crops, and many more. It is also used
as a seed treatment of cotton, potatoes, corn, safflower,
sorghum, peanuts, tomatoes, flax, and cereal grains | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions) if
breathing has stopped, and CPR if heart action has stopped.
Transfer promptly to a medical facility. When this chemical
has been swallowed, get medical attention. If victim is
conscious and able to swallow, have victim drink 4 to 8 oz
of water. Do not induce vomiting. | [Shipping]
UN2771 Dithiocarbamate and Thiocarbamate
pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-
Poisonous materials. | [Incompatibilities]
Combustible material. Dust may form
explosive mixture in air. Decomposes in temperatures
above 170C. Keep away from water, acid, oxidizing
materials. Dithiocarbamate esters are combustible. They
react violently with powerful oxidizers such as calcium
hypochlorite. Poisonous gases are generated by the thermal
decomposition of Dithiocarbamate compounds, including
carbon disulfide, oxides of sulfur, oxides of nitrogen,
hydrogen sulfide, ammonia, and methylamine. Thio and
dithiocarbamates slowly decompose in aqueous solution to
form carbon disulfide and methylamine or other amines.
Such decompositions are accelerated by acids. Flammable
gases are generated by the combination of dithiocarbamate
with aldehydes, nitrides, and hydrides. Dithiocarbamate are
incompatible with acids, peroxides, and acid halides.
Corrosive to iron, copper brass, and zinc metals, especially
in the presence of moisture. Contact with lime, moisture
can cause decomposition. Decomposes on prolonged
storage. Degradation produces ethylene thiourea.
| [Description]
Mancozeb is a fungicide of the ethylene-bis-dit-hiocarbamate
group. It is present in Rondo-M
with pyrifenox. Occupational exposure occurs mainly
in agricultural workers, in vineyard workers or in
florists.
| [Chemical Properties]
Grayish-yellow powder | [Waste Disposal]
Disposal Method Suggested:
Generators of waste (equal to or greater than 100 kg/mo)
containing this contaminant, EPA hazardous waste number
N450, must conform to USEPA regulations for storage,
transportation, treatment, and disposal of waste. Dispose of waste material as hazardous waste using a licensed disposal
contractor to an approved landfill. Dispose of contents and
container to an approved waste disposal plant. Containers
must be disposed of properly by following package label
directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA
office. All federal, state, and local environmental regulations must be observed. Do not discharge into drains or
sewers. A potential candidate for liquid injection incineration at a temperature range of 650 to 1600C and a residence time 0.1 to 2 seconds. Also, a potential candidate for
rotary kiln incineration at a temperature range of 820 to
1600C and residence times of seconds for liquids and
gases, and hours for solids. | [Agricultural Uses]
Fungicide: Mancozeb is used to control a wide variety of fungal
diseases, including potato blight, leaf spot, scab (on apples
and pears), and rust (on roses). It is used on fruits, vegetables,
nuts and field crops, and many more. It is also used as
a seed treatment of cotton, potatoes, corn, safflower, sorghum,
peanuts, tomatoes, flax, and cereal grains. | [Trade name]
ACROBAT® (mancozeb + dimethomorph);
ASHLAND SOLACE® (cymoxanil + mancozeb);
CARMAZINE®; CUPROFIX®; DITHANE®;
EMCARB® (mancozeb + carbendez); EMTHANE M-15®;
EVOLVE®; F 2966®; FORE®; FORMEC®; GAUCHO®
(imidacloprid + mancozeb); GAVEL® (mancozeb + zoxamide);
GREEN-DAISEN M®; KARAMATE®;
KENCOZEB®; MANCOFOL®; MANOSEB®;
MANTOX®; MANZATE 200®; MANZEB®; MANZIN
80®; MARZIN®; MAXIM®; MILOR®; NEMISPOR®;
PACE® fungicide (mixture of mancozeb and metalaxyl);
PENNCOZEB®; POLICAR®; TRIZIMAN®;
TRIZIMAN-D®; VONDOZEB PLUS®; ZIMANAT®;
ZIMMAN-DITHANE®; ZIMANEB® | [Environmental Fate]
Plant. Undergoes metabolism in plants to ethyl thiourea, ethylene thiuram disulfide,
thiuram monosulfide and sulfur (Hartley and Kidd, 1987).
Chemical/Physical. Decomposes in acids releasing carbon disulfide. In oxygenated
waters, mancozeb degraded to ethylene thiuram monosulfide, ethylene diisocyanate, ethylene
thiourea, ethylenediamine and sulfur (Worthing and Hance, 1991). | [Metabolic pathway]
Mancozeb is a mixture containing maneb and zineb as the active ingredients.
Maneb and zineb and other alkylenebis( dithiocarbamate) fungicides
are degraded and metabolised via a common pathway. The primary
degradation reaction of maneb and zineb in water, soil, plants and
animals involves the initial dissociation of the metal complex and
decomposition to numerous degradation products including ethylenethiourea
(ETU) and ethyleneurea (EU) as major products. See zineb
and maneb summaries for detailed descriptions. | [storage]
Store at -20°C | [Degradation]
Mancozeb (1) was readily hydrolysed in neutral and alkaline solution
with DT9 values of 20 days (pH 5), 17 hours (pH 7) and 34 hours (pH 9)
(PM). See zineb and maneb summaries for the hydrolytic degradation
pathway. | [Toxicity evaluation]
The mechanism of toxicity for MZ is similar to other EBDC
fungicides like maneb. EBDC are able to modify and inactivate
redox-sensitive proteins. Because of the thiol reactivity of
these compounds, redox-sensitive processes like transcription,
translation, and other metabolic processes can be altered,
resulting in cytotoxicity. It is due to this multitarget mode of
action that MZ and other EBDC compounds are used in
fungicide resistance management programs. In contrast to
other fungicidal agents, in over 40 years of use, resistance to
any of the EBDC compounds has never developed. MZ has
also been reported to cause oxidative stress, DNA damage, and
apoptosis in rat cells. Additionally, like all EBDC, MZ can act
as a chelating agent, allowing it to interfere with enzymes that
contain metals which are essential for activity, like dopamine
b-hydroxylase. |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R37:Irritating to the respiratory system.
R43:May cause sensitization by skin contact. | [Safety Statements ]
S8:Keep container dry .
S24/25:Avoid contact with skin and eyes .
S46:If swallowed, seek medical advice immediately and show this container or label . | [RIDADR ]
UN 2210 | [RTECS ]
ZB3200000 | [HazardClass ]
9 | [PackingGroup ]
III | [HS Code ]
29309090 | [Hazardous Substances Data]
8018-01-7(Hazardous Substances Data) | [Toxicity]
LC50 (48-hour) for carp 4.0 mg/L (Hartley and Kidd, 1987), catfish 5.2 mg/L,
goldfish 9.0 mg/L (21°C) and rainbow trout 2.2 mg/L (17°C) (Worthing and Hance, 1991);
acute oral LD50 for rats >8,000 mg/kg (Hartley and Kidd, 1987), mouse 600 mg/kg
(RTECS, 1985). |
|
|