| Identification | More | [Name]
Mitoxantrone hydrochloride | [CAS]
70476-82-3 | [Synonyms]
1,4-DIHYDROXY-5,8-BIS[2-[(2-HYDROXYETHYL)AMINO]ETHYL]AMINO]-9,10-ANTHRACENEDIONE DIHYDROCHLORIDE
1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthraquinone dihydrochloride
DHAQ
DHAQ DIHYDROCHLORIDE
MITOXANTHRONE HCL
MITOXANTRONE DIHYDROCHLORIDE
MITOXANTRONE HCL
MITOXANTRONE HYDROCHLORIDE
MITOXANTRONE HYDROCHLORIDE SALT
mitozantrone hydrochloride
novantrone
1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-anthracenedion
cl232315
MITOXANTRONE HCL USP
Mitoxantrone2Hcl
MitoxantroneHclEp5
1,4-Dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)anthrachinondihydrochlorid
Mitoxantron HCl
1,4-DIHYDROXY-5,8-BIS-[2-(2-HYDROXYETHYLAMINO)ETHYLAMINO]ANTHRAQUINONE 2HCL
1,4-Dihydroxy-5,8-bis-[2-(2- | [EINECS(EC#)]
274-619-1 | [Molecular Formula]
C22H30Cl2N4O6 | [MDL Number]
MFCD00242943 | [Molecular Weight]
517.4 | [MOL File]
70476-82-3.mol |
| Chemical Properties | Back Directory | [Appearance]
Dark blue, electrostatic, hygroscopic powder. | [Melting point ]
203-205 C | [storage temp. ]
2-8°C | [solubility ]
Sparingly soluble in water, slightly soluble in methanol, practically insoluble in acetone. | [form ]
neat | [color ]
Dark Blue to Black | [Water Solubility ]
Soluble to 5 mM in water and to 75 mM in DMSO | [InChI]
InChI=1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H | [InChIKey]
ZAHQPTJLOCWVPG-UHFFFAOYSA-N | [SMILES]
C1(O)=C2C(C(=O)C3=C(C2=O)C(NCCNCCO)=CC=C3NCCNCCO)=C(O)C=C1.[H]Cl.[H]Cl | [CAS DataBase Reference]
70476-82-3(CAS DataBase Reference) | [EPA Substance Registry System]
70476-82-3(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T,T+ | [Risk Statements ]
R61:May cause harm to the unborn child.
R26/27/28:Very Toxic by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S53:Avoid exposure-obtain special instruction before use .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S22:Do not breathe dust . | [RIDADR ]
3249 | [WGK Germany ]
3
| [RTECS ]
CB5748500
| [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
29146100 | [Hazardous Substances Data]
70476-82-3(Hazardous Substances Data) |
| Hazard Information | Back Directory | [Description]
Mitoxantrone hydrochloride is the first of the synthetic anthracenediones related
to doxorubicin to reach the marketplace. Mitoxantrone is useful in the treatment
of advanced localized and metastatic mammary carcinomas. It is reported to be
less cardiotoxic than doxorubicin. | [Description]
Mitoxantrone is an anthraquinone that intercalates in DNA and inhibits topoisomerase II (IC50 = 5.3 μM), thus inhibiting cell proliferation.1,2 It also inhibits HIV-1 integrase (IC50 = 3.8 μM).3 Mitoxantrone is exported from cells in an ATP- and glutathione-dependent manner by multidrug resistance protein-1.4 Formulations containing mitoxantrone have been used in the treatment of cancer and multiple sclerosis.5,6,7 | [Chemical Properties]
Dark blue, electrostatic, hygroscopic powder. | [Originator]
Lederle (USA) | [Uses]
analgesic, antipyretic | [Uses]
Mitoxanthrone hydrochloride USP (Novantrone) is used to traet acute nonlymphocytic leukemia, including myelogenous promyelocytic, monocytic, and erythroid acute leukemias. | [Uses]
Mitoxantrone dihydrochloride is an antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting Topo II (topoisomerase II). Mitoxantrone dihydrochloride induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Mitoxantrone dihydrochloride has recently been shown to be an inhibitor of DNA methylation. | [Definition]
ChEBI: Mitoxantrone dihydrochloride is a hydrochloride. It has a role as an antineoplastic agent. It contains a mitoxantrone. | [Manufacturing Process]
A suspension of 12.5 g of 2-(2-aminoethylamino)ethanol in 40 ml of
N,N,N',N'-tetramethylethylenediamine is stirred and de-aerated by bubbling
nitrogen in for 15 min. A 10.97 g of leuco-1,4,5,8-tetrahydroxyanthraquinone
is gradually added with stirring. The suspension is heated and stirred under
nitrogen at 50-52°C for 5 hours. The mixture is allowed to stand and cool
under nitrogen for 12 hours. The solid is collected by decantation, macerated
in ethanol, collected and washed with ethanol giving 15.06 g of the desired
product leuco-1,4-bis[2-(2-hydroxyethylamino)ethylamino]-5,8-
dihydroxyanthraquinone as a green-gray solid, melting point 129-131°C.
Chloranil oxidation. To 17.86 g of a suspension of the leuco-1,4-bis[2-(2-
hydroxyethylamino)ethylamino]-5,8-dihydroxyanthraquinone (0.03 mole) in 2-
methoxyethanol was added gradually with stirring 15 ml of 8 N ethanolic
hydrogen chloride. The system was chilled with an ice bath and stirred as 7.50
g (0.0305 mole) of chloranil powder was gradually added. The mixture was
stirred overnight at room temperature and diluted with 600 ml of ether. The
solid was collected and washed with tetrahydrofuran. Yield of 1,4-bis[2-(2-
hydroxyethylamino)ethylamino]-5,8-dihydroxyanthraquinone dihydrochloride
21.34 g, melting point 203-205°C (without recrystallisation). | [Brand name]
Novantrone (Serono). | [Therapeutic Function]
Antineoplastic | [General Description]
Mitoxantrone is supplied as a blue aqueous solution in 10-and 20-mg vials for IV administration in the treatment of acute lymphoid leukemia, acute myeloid leukemia, breastcancer, prostate cancer, non-Hodgkin’s lymphoma, andmultiple sclerosis. The mechanisms of resistance are thesame as those seen for the anthracyclines. The distributionhalf-life is 1.1 to 3.1 hours, and the drug has a large volumeof distribution (11 L/kg). The elimination half-life rangedfrom 23 to 215 hours, and elimination was primarily via thebile. Metabolism of the agent involves oxidation of the sidechainalcohols to give the monocarboxylic and dicarboxylicacids.Other toxicities are those seen for the anthracyclinesand include myelosuppression, nausea, vomiting, mucositis,diarrhea, and alopecia. The intense color of the parent drugand metabolites may turn the urine blue. | [Biological Activity]
Mitoxantrone hydrochloride (Mitoxantrone dihydrochloride) is a type II DNA topoisomerase inhibitor. Disrupts DNA synthesis and repair and induces damage by DNA cross-linking. Also inhibits PIM1 kinase (IC50 = 51 nM). Immunomodulatory, antineoplastic and chemotherapeutic agent. Also USP11 inhibitor (IC50= 3.15 μM). Induces cell death of pancreatic cancer cell lines expressing wild-type BRCA2. | [Biochem/physiol Actions]
Mitoxantrone is a cytostatic anthracenedione that intercalates in DNA and increases the incidence of double-strand breaks by stabilizing the cleavable complex of topoisomerase II and DNA. Mitoxantrone also displays broad immunosuppressive activity inhibiting proliferation of all classes of lymphocytes and inducing apoptosis of antigen-presenting T cells. It used clinically as a chemotherapeutic agent against leukemias and solid tumors and as an immune system modulator in multiple sclerosis. | [Clinical Use]
Mitoxantrone is used in combination with other agents during the initial treatment of acute nonlymphocytic leukemia and hormone-refractory prostate cancer. Recent studies have shown that mitoxantrone also decreases the rate of relapse and disease progression in patients with multiple sclerosis. Although too toxic for use in patients with primary progressive disease, it is available for the treatment of chronic progressive, progressive relapsing, or deteriorating relapsing-remitting multiple sclerosis. | [Side effects]
Common side effects of Mitoxantrone hydrochloride include: Swelling of the body; Infection, possibly in the blood, especially when white blood cell count is low; Sores in mouth and throat which may cause difficulty swallowing; Diarrhea, nausea, vomiting; Headache; Pain in belly, back, joints, or muscles; Abnormal or absence of menstrual period; Tiredness, fever; Hair loss; Hives, rash. Less common side effects include: Damage to the heart or heart failure which may cause shortness of breath, tiredness and swelling; Bruising, bleeding; Anemia which may cause tiredness, or may require transfusion; Liver damage which may cause yellowing of eyes and skin, swelling; Internal bleeding which may cause belly pain, black tarry stool, blood in vomit; Constipation, loss of appetite; Abnormal sexual function; Worry, depression; Swelling and redness at the site of the injection; Changes in weight; Swelling and redness of the whites of the eye; Increased sweating; Loss of nails, darkening of the skin and nails; Bluish/greenish discoloration of the urine, skin, eyes and saliva. A rare side effect is bone marrow cancer (leukaemia) caused by chemotherapy. | [Metabolism]
Mitoxantrone excretion primarily is biliary. Both the unchanged drug and inactive metabolites resulting from N-dealkylation, deamination, and oxidation of the resultant aldehyde to the carboxylic acid are observed. Both arms of the structure can be metabolized, leading to mono- or dicarboxylic acid metabolites, which are excreted as the glucuronide conjugate. The conjugated metabolites are an intense, dark blue in color and will result in blue-green urine. | [storage]
Desiccate at RT |
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