| Identification | More | [Name]
Cytidine | [CAS]
65-46-3 | [Synonyms]
CYTIDINE HYDROCHLORIDE
1beta-D-Ribofuranosylcytosine
1-beta-ribofuranosylcytosine
1beta-Ribofuranosylcytosine
2(1H)-Pyrimidinone, 4-amino-1-beta-D-ribofuranosyl-
4-amino-1-beta-d-ribofuranosyl-2(1h)-pyrimidinon
beta-D-Ribofuranoside, cytosine-1
Cyd
Cytidin
Cytosine, 1-beta-D-ribofuranosyl-
Cytosine β-D-riboside
Cytosine-1-β-D-ribofuranoside
CYTIDINE FREE BASE CELL CULTURE TESTED
Cytosine-1-β-D-ribofuranos
CytidineForBiochemistry
Cytidene,>98%
4-Amino-L-β-D-ribofuranosyl-2-[1H]-pyrimidinone
Citidine
Cytidine, 99+%
CYTIDINE(Cytosine-1--D-ribofuranoside) | [EINECS(EC#)]
200-610-9 | [Molecular Formula]
C9H13N3O5 | [MDL Number]
MFCD02181091 | [Molecular Weight]
243.22 | [MOL File]
65-46-3.mol |
| Chemical Properties | Back Directory | [Appearance]
White crystalline powder | [Melting point ]
210-220 °C (dec.) (lit.) | [alpha ]
31.5 º (c=0.6, H2O 25 ºC) | [Boiling point ]
386.09°C (rough estimate) | [density ]
1.3686 (rough estimate) | [refractive index ]
34 ° (C=0.7, H2O) | [storage temp. ]
Store at RT. | [solubility ]
H2O: 50 mg/mL
| [form ]
powder
| [pka]
4.22, 12.5(at 25℃) | [color ]
White to almost white | [Stability:]
Stable. Incompatible with strong oxidizing agents. Protect from moisture. | [optical activity]
[α]20/D +33°, c = 2 in H2O | [Water Solubility ]
SOLUBLE | [Sensitive ]
Hygroscopic | [Merck ]
14,2786 | [BRN ]
89173 | [LogP]
-1.808 (est) | [CAS DataBase Reference]
65-46-3(CAS DataBase Reference) | [NIST Chemistry Reference]
Cytidine(65-46-3) | [EPA Substance Registry System]
65-46-3(EPA Substance) |
| Safety Data | Back Directory | [Risk Statements ]
R68:Possible risk of irreversible effects. | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [RTECS ]
UW7370000
| [F ]
10-23 | [TSCA ]
Yes | [HS Code ]
29349900 | [Toxicity]
LD50 intraperitoneal in mouse: 2700mg/kg |
| Hazard Information | Back Directory | [Description]
Cytidine is a pyrimidine nucleoside that is composed of the pyrimidine base cytosine attached to the sugar ribose. As a constituent of RNA, cytidine pairs with guanine, and it is a precursor of uridine. Cytidine can incur several modifications in mRNA, including methylation and acetylation, that function to regulate translation.1 Cytidine can also be formylated to 5-formylcytidine in mitochondrial methionine transfer RNA (tRNAMet).2 | [Chemical Properties]
Cytidine is a component of RNA. It is a white water-soluble solid. which is only slightly soluble in ethanol.There are a variety of cytidine analogs with potentially useful pharmacology. | [Uses]
Cytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring, cytidine is a component of RNA. It was isolated from yeast nucleic acid. It can increases cell membrane phospholipids. Cytidine is used to synthesize enzyme inhibitors, antiviral agents, and anticancer agents. And also used as constituent of nucleic acids. | [Application]
Cytidine has been used as a non-essential aminoacid component of minimal essential medium (MEM) to analyse interspecies somatic cell nucleus transfer (iSCNT)-derived blastocysts. It has also been used as a supplement in the culture medium of HeLa cells, to study the effects of cytidine addition on rods and rings (RR) induced by glutamine deprivation.
Cytidine has been used as a component to prepare ribonucleoside stock solution to assess its effects on the anaerobic growth of several Bacillus mojavensis strains. | [Definition]
ChEBI: cytidine is a pyrimidine nucleoside in which cytosine is attached to ribofuranose via a beta-N(1)-glycosidic bond. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It derives from a cytosine.The derivednucleotides, cytidine mono-, di-, andtriphosphate (CMP, CDP, and CTP respectively)participate in various biochemicalreactions, notably inphospholipid synthesis. | [General Description]
White crystalline powder. | [Air & Water Reactions]
Cytidine is hygroscopic. Water soluble. | [Reactivity Profile]
Cytidine(65-46-3) is incompatible with strong oxidizing agents. . Will react as a weak base. | [Fire Hazard]
Flash point data for Cytidine are not available; however, Cytidine is probably combustible. | [Purification Methods]
Cytidine crystallises from 90% aqueous EtOH. It has also been converted to sulfate by dissolving (~200mg) in a solution of EtOH (10mL) containing H2SO4 (50mg), whereby the salt crystallises out. It is collected, washed with EtOH and dried for 5hours at 120o/0.1mm. The sulfate has m 225o. The free base is obtained by shaking the salt solution with a weak ion-exchange resin, filtering, evaporating and recrystallising the residue from EtOH as before. [Fox & Goodman J Am Chem Soc 73 3256 1956, Fox & Shugar Biochim Biophys Acta 9 369 1952; see Prytsas & Sorm in Synthetic Procedures in Nucleic Acid Chemistry (Zorbach & Tipson Eds) Vol 1 404 1973.] [Beilstein 25 III/IV 3667.] |
| Questions And Answer | Back Directory | [Structure]
The crystal specimens were kindly supplied by Dr. D. O. Jordan, University of Nottingham, and were found to be orthorhombic with {110} dominating. An optical investigation shows that the sign is positive, with α∥c, β∥b and γ∥a. Cell dimensions are: a = 13·93 A., b = 14·75 A., c = 5·10 A.; density, 1·53; four molecules per unit cell; space-group, P 212121.
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