| Identification | More | [Name]
N-Methyl-D-aspartic acid | [CAS]
6384-92-5 | [Synonyms]
H-D-MEASP-OH
H-D-MEASP-OH HCL
N-ALPHA-METHYL-D-ASPARTIC ACID
N-ALPHA-METHYL-D-ASPARTIC ACID HYDROCHLORIDE
NMDA
N-ME-D-ASPARTIC ACID
N-ME-D-ASP-OH
N-ME-D-ASP-OH HCL
N-METHYL-D-ASPARAGINIC ACID
N-METHYL-D-ASPARTIC ACID
N-METHYL-D-ASPARTIC ACID HYDROCHLORIDE
[R]-2-[METHYLAMINO]SUCCINIC ACID
n-methylaspartate
n-methyl-d-aspartate
n-methyl-d-asparticaci
N-Methyl D-artic acid.
(2R)-2-methylaminobutanedioic acid
(R)-2-(Methylamino)succinic acid, NMDA
(R)-2-(Methylamino)butanedioic acid
N-Methyl-D-Asp-OH | [EINECS(EC#)]
227-012-0 | [Molecular Formula]
C5H9NO4 | [MDL Number]
MFCD06795789 | [Molecular Weight]
147.13 | [MOL File]
6384-92-5.mol |
| Chemical Properties | Back Directory | [Appearance]
white to off-white crystalline powder | [Melting point ]
187-192 °C
| [alpha ]
-28 º (c=1, HCl 6N) | [Boiling point ]
267.21°C (rough estimate) | [density ]
1.4285 (rough estimate) | [refractive index ]
-15 ° (C=2, H2O) | [storage temp. ]
Store at RT. | [solubility ]
Aqueous Acid (Slightly), DMSO (Slightly), Water (Slightly) | [form ]
solid
| [pka]
2.21±0.23(Predicted) | [color ]
white
| [Water Solubility ]
slightly soluble | [Sensitive ]
Hygroscopic | [Merck ]
6662 | [BRN ]
1724431 | [LogP]
1.390 (est) | [CAS DataBase Reference]
6384-92-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [RTECS ]
CI9457000
| [F ]
10 | [HS Code ]
29225090 |
| Hazard Information | Back Directory | [Chemical Properties]
white to off-white crystalline powder | [Uses]
NMDA agonist | [Definition]
ChEBI: An aspartic acid derivative having an N-methyl substituent and D-configuration. | [General Description]
N-Methyl-D-aspartic acid (NMDA) is an endogenously generated molecule in rat nervous system and endocrine glands. NMDA is present at low level (nmol/g) in the adenohypophysis, hypothalamus, brain, and testis. NMDA is derived from D-Asp by an S-adenosylmethionine-dependent enzyme also referred to as NMDA synthase. | [Biological Activity]
Prototypic NMDA receptor agonist. Also available as part of the Mixed NMDA Receptor Tocriset™ . | [Biochem/physiol Actions]
Excitotoxic amino acid. Prototypic agonist at the NMDA-type glutamate receptor that regulates ion channels; important in long-term potentiation, ischemia, and epilepsy. | [storage]
Room temperature | [References]
[1] watkins jc, jane de. the glutamate story. br j pharmacol. 2006 jan;147 suppl 1:s100-8.
[2] lafon-cazal m, pietri s, culcasi m, bockaert j. nmda-dependent superoxide production and neurotoxicity. nature. 1993 aug 5;364(6437):535-7. |
|
|