天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook--->CAS DataBase List--->63675-72-9

63675-72-9

63675-72-9 Structure

63675-72-9 Structure
IdentificationMore
[Name]

Nisoldipine
[CAS]

63675-72-9
[Synonyms]

1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID METHYL 2-METHYLPROPYL ESTER
BAY K 5552
BAYMYCARD
NISOLDIPINE
NISOLIDIPINE
NORVASC
SYSCOR
ZADIPINA
5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-met
hyl2-methylpropylester
Nisoldipin
ISOBUTYL METHYL (-1,4-DIHYDRO-2,6-DIMETHYL-4-(2-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLATE
Baymycard, Norvasc, Syscor, Zadipina, 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic Acid Methyl 2-methylpropyl Ester
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, methyl 2-methylpropyl ester (9CI)
Nisocor
Sular
Nisoldipine-d6
2,6-Dimethyl-4-(2-nitmphenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid methyl 2-methylpropyl ester
Syseor
1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-isobutyl ester
[EINECS(EC#)]

264-407-7
[Molecular Formula]

C20H24N2O6
[MDL Number]

MFCD00478055
[Molecular Weight]

388.41
[MOL File]

63675-72-9.mol
Chemical PropertiesBack Directory
[Appearance]

Light Tan Crystals
[Melting point ]

147-148°C
[Boiling point ]

503.3±50.0 °C(Predicted)
[density ]

1.205±0.06 g/cm3(Predicted)
[storage temp. ]

room temp
[solubility ]

DMSO: >10mg/mL
[form ]

powder
[pka]

2.67±0.70(Predicted)
[color ]

yellow
[Usage]

Dihydropyridine calcium channel blocker. Antihypertensive and antianginal
[Merck ]

14,6565
[InChIKey]

VKQFCGNPDRICFG-UHFFFAOYSA-N
[CAS DataBase Reference]

63675-72-9(CAS DataBase Reference)
[NIST Chemistry Reference]

Nisoldipine(63675-72-9)
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

20/21/22
[Safety Statements ]

36
[WGK Germany ]

3
[RTECS ]

US7975600
[HS Code ]

2933399090
Raw materials And Preparation ProductsBack Directory
[Raw materials]

2-Nitrobenzaldehyde-->Methyl 3-aminocrotonate-->Isobutyl acetoacetate-->nifedipine iMpurity C-->Nifedipine-->Isobutyl 2-(2-Nitro-Benzylidene)Acetoacetate-->Nicardipine-->2,3-Diamino-2,3-dimethylbutane-->methyl 3-aminocrotonate
Hazard InformationBack Directory
[Description]

Nisoldipine D4  is another long-acting dihydropyridine calcium channel blocker effective in the treatment of hypertension and angina pectoris. It is reported to have little or no cardiodepressive activity and to be more effective than nifedipine in reducing blood pressure in hypertensives. Nisoldipine has also been shown to be effective in the management of congestive heart failure. Reduction in dosage is necessary in patients with hepatic, but not renal impairment.
[Chemical Properties]

Nisoldipine D4 is Light Tan Crystals
[Originator]

Bayer AG (Germany)
[Uses]

Dihydropyridine calcium channel blocker. Antihypertensive and antianginal
[Uses]

Labeled Nisoldipine, intended for use as an internal standard for the quantification of Nisoldipine by GC- or LC-mass spectrometry.
[Uses]

urease inhibitor
[Definition]

ChEBI: A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a methoxycarbonyl group at position 3, an o-nitrophenyl group at position 4, and an isobutoxycarbonyl group at position 5. The racemate, calcium channel blocker, is used in the treatment of hypertension and angina pectoris.
[Manufacturing Process]

Boiling a solution of 12.7 g of 2'-nitrobenzylideneacetoacetic acid methyl ester and 7.1 g of β-amino-crotonic acid isopropyl ester in 50 ml of methanol for 10 hours yielded 2,6-dimethyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-3,5- dicarboxylic acid 3-methyl ester-5-isopropyl ester of melting point 174°C (from ethanol). Yield 48% of theory.
[Brand name]

Sular (Sciele);Baymycard.
[Therapeutic Function]

Coronary vasodilator
[General Description]

In vitro studies show that the effects ofnisoldipine, 1,4-dihydro-2, 6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinecarboxylic acid methyl 2-methylpropyl ester(Sular), on contractile processes are selective, with greaterpotency on vascular smooth muscle than on cardiac muscle.
Nisoldipine is highly metabolized, with five majormetabolites identified. As with most of the dihydropyridines,the cytochrome P450 (CYP) 3A4 isozyme is mainlyresponsible for the metabolism of nisoldipine. The majorbiotransformation pathway appears to involve the hydroxylationof the isobutyl ester side chain. This particular metabolitehas approximately 10% of the activity of the parentcompound.
[Biochem/physiol Actions]

L-type (CaV1.2) calcium channel blocker; dihydropyridine-type calcium channel blocker with selectivity for smooth muscle (CaV1.2b) over cardiac muscle (CaV1.2a). Arterial vasodilator and antihypertensive agent.
Spectrum DetailBack Directory
[Spectrum Detail]

Nisoldipine(63675-72-9)1HNMR
63675-72-9 suppliers list
Company Name: Hebei Weibang Biotechnology Co., Ltd
Tel: +8615531157085 , +8615531157085
Website: www.weibangbio.com/
Company Name: Hebei Mojin Biotechnology Co., Ltd
Tel: +86 13288715578 +8613288715578 , +8613288715578
Website: http://www.mojinchemical.com
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512 , +86-19937530512
Website: https://www.tianfuchem.com/
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
Website: www.approvedhomemanagement.com/ShowSupplierProductsList30845/0.htm
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com/
Company Name: Jinan Jianfeng Chemical Co., Ltd
Tel: 0531-88110457; +8615562555968 , +8615562555968
Website: http://www.approvedhomemanagement.com/manufacturer/ShowSupplierProductsList31185/
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 18871490254
Website: www.hubeijusheng.com
Company Name: Hebei Jimi Trading Co., Ltd.
Tel: +86 319 5273535
Website: www.hebeijimi.com
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-023-6139-8061 +86-86-13650506873 , +86-86-13650506873
Website: http://www.chemdad.com/
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427 , +8618523575427
Website: http://www.conier.com/
Company Name: Zhengzhou Alfa Chemical Co.,Ltd
Tel: +8618530059196 , +8618530059196
Website: http://www.approvedhomemanagement.com/manufacturer/zhengzhou-alfa-chemical-276/
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
Website: https://www.targetmol.com/
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-029-89586680 +86-18192503167 , +86-18192503167
Website: www.dideu.com
Company Name: AFINE CHEMICALS LIMITED
Tel: +86-0571-85134551
Website: www.afinechem.com/index.html
Company Name: Wuhan Fortuna Chemical Co., Ltd
Tel: +86-027-59207850
Website: www.fortunachem.com/
Company Name: Baoji Guokang Bio-Technology Co., Ltd.
Tel: 0917-3909592 13892490616 , 13892490616
Website: http://www.gk-bio.com
Company Name: Baoji Guokang Healthchem co.,ltd
Tel: +8615604608665 15604608665 , 15604608665
Website: www.gk-bio.com
Company Name: XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
Tel: +86-029-86333380 18829239519 , 18829239519
Website: https://www.tgybiotech.com/
Tags:63675-72-9 Related Product Information
77-78-1 616-38-6 100-26-5 62-23-7 74-84-0 18479-58-8 89-00-9 68-12-2 115-10-6 67-68-5 75-18-3 624-49-7 108-48-5 106-79-6 66085-59-4 55985-32-5 39562-70-4 74191-85-8