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ChemicalBook--->CAS DataBase List--->55985-32-5

55985-32-5

55985-32-5 Structure

55985-32-5 Structure
IdentificationMore
[Name]

Nicardipine
[CAS]

55985-32-5
[Synonyms]

NICARDIPINE
benzylmethylamino)ethylmethylester
2-(benzylmethylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)pyridine-3,5-dicarboxylate
NicardipineBase
Nicardipine Hcl 54527-84-3/Base
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid methyl 2-[methy(phenyl-methyl)amino]ethyl ester hydrochloride
Nicardipine (base and/or unspecified salts)
Methyl 2-(benzyl-methyl-amino)ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[2-[methyl(benzyl)amino]ethyl]5-methyl ester
2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-methyl 5-[2-[methyl(benzyl)amino]ethyl] ester
2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-[2-(N-methylbenzylamino)ethyl] ester
[EINECS(EC#)]

259-932-3
[Molecular Formula]

C26H29N3O6
[MDL Number]

MFCD00216027
[Molecular Weight]

479.52
[MOL File]

55985-32-5.mol
Chemical PropertiesBack Directory
[Melting point ]

136-138 °C
[Boiling point ]

603.4±55.0 °C(Predicted)
[density ]

1.230±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Dichloromethane; Methanol
[form ]

Solid
[pka]

7.30±0.50(Predicted)
[color ]

Yellow
[CAS DataBase Reference]

55985-32-5(CAS DataBase Reference)
Raw materials And Preparation ProductsBack Directory
[Raw materials]

3-Nitrobenzaldehyde-->Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate-->trans-Methyl crotonate-->3,5-Pyridinedicarboxylic acid-->Butanoic acid, 3-oxo-, 3-(nitrooxy)propyl ester-->3-(2-hydroxyethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate-->N-Benzyl-N-methylethanolamine-->N-Methylbenzylamine
[Preparation Products]

Nisoldipine
Hazard InformationBack Directory
[Originator]

Nicodel,Mitsui,Japan,1981
[Uses]

It is used for arterial hypertension, chronic, stable angina pectoris, preventing angina pectoris, and for ischemic-type abnormalities of brain blood flow.
[Uses]

Nicardipine is a dihydropyridine calcium channel blocker. Antianginal; antihypertensive. Neuroprotective & Neuroresearch products.
[Uses]

Vasodilator.
[Definition]

ChEBI: Nicardipine is a racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension. It has a role as an antihypertensive agent, a calcium channel blocker, a vasodilator agent and an autophagy inhibitor. It contains a (S)-nicardipine and a (R)-nicardipine.
[Manufacturing Process]

A mixture of 4.98 g of acetoacetic acid N-benzyl-N-methylaminoethyl ester, 2.3 g of β-aminocrotonic acid methyl ester, and 3 g of m-nitrobenzaldehyde was stirred for 6 hours at 100°C in an oil bath. The reaction mixture was subjected to a silica gel column chromatography (diameter 4 cm and height 25 cm) and then eluted with a 20:1 mixture of chloroform and acetone. The effluent containing the subject product was concentrated and checked by thin layer chromatography. The powdery product thus obtained was dissolved in acetone and after adjusting the solution with an ethanol solution saturated with hydrogen chloride to pH 1-2, the solution was concentrated to provide 2 g of 2,6-dimethyl-4-(3'-nitrophenyl)1,4-dihydropyridine-3,5-dicarboxylic acid 3-methylester-5-β-(N-benzyl-N-methylamino)ethyl ester hydrochloride. The product thus obtained was then crystallized from an acetone mixture, melting point 136°C to 140°C (decomposed).
[Brand name]

Cardene(PDL Biopharma); Cardene (Roche).
[Therapeutic Function]

Vasodilator
[Mechanism of action]

Nicardipin relaxes smooth musculature of vessels, lowers resistance of coronary and peripheral vessels, increases blood flow in vessels of the brain, causes a moderate and stable hypotensive effect, and reduces the myocardial need for oxygen.
[Synthesis]

Nicardipine, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-methyl-2-[(methylphenylmethyl)- amino]ethyl ester 3,5-pirididincarboxylic acid (19.3.7), is synthesized in a manner analogous to the synthesis of nifedipine, the only difference being that in the Hantsch synthesis, two different |?-dicarbonyl compounds are used simultaneously with o-nitrobenzaldehyde. During this, one of these in the enamine form of acetoacetic ester is simultaneously used as an amine component. A heterocyclization reaction is accomplished by reacting, the methyl ester of |?-aminocrotonic acid with the 2-methyl-2-benzylaminoethyl ester of acetoacetic acid.

Synthesis_55985-32-5

[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

Nicardipine(55985-32-5)1HNMR
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