| Identification | More | [Name]
Clopamide | [CAS]
636-54-4 | [Synonyms]
4-CHLORO-N-[2,6-DIMETHYLPIPERIDINYL]-3-SULFAMOYLBENZAMIDE
CLOPAMIDE
4-chloro-N-(2,6-dimethylpiperidino)-3-sulphamoylbenzamide
4-Chloro-N-[2,6-dimethylpiperidino]-3-sulfamolybenzamide
CLOPAMIDUM
4-Chloro-N-(cis-2,6-dimethylpiperidino)-3-sulfamoylbenzamide
4-Chloro-N-[(2R,6S)-2,6-dimethylpiperidino)-3-sulfamoylbenzamide
Adurix
Aquex
Brinaldix
DT-327 | [EINECS(EC#)]
211-261-7 | [Molecular Formula]
C14H20ClN3O3S | [MDL Number]
MFCD00941495 | [Molecular Weight]
345.84 | [MOL File]
636-54-4.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R42/43:May cause sensitization by inhalation and skin contact . | [Safety Statements ]
S36:Wear suitable protective clothing . | [WGK Germany ]
3
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| Hazard Information | Back Directory | [Chemical Properties]
White or almost white, hygroscopic, crystalline powder | [Originator]
Brinaldix,Novartis | [Uses]
Antihypertensive; diuretic. | [Uses]
Antihypertensor;Gonad stimuling agent | [Uses]
Clopamide is a thiazide-like diuretic that inhibits sodium/chloride cotransporters in the proximal convoluted tubule of the kidney, which prevents the reabsorption of sodium and chloride. This compound is intended for research purposes only. | [Definition]
ChEBI:4-chloro-N-[(2S,6R)-2,6-dimethyl-1-piperidinyl]-3-sulfamoylbenzamide is a sulfonamide. | [Manufacturing Process]
To a solution of 5.5 g of 3-chlorsulfonyl-4-chlorobenzoylchloride in 20 ml
chlorobenzole 3.3 g of 1-amino-cis-2,6-dimethylpiperidin-hydrochloride slowly
was added at room temperature. Reaction mixture was heated to 100°-105°C
during 8 h, then it was cooled to room temperature. The precipitated crystals
of N-[cis-2,6-dimethyl-piperidyl-(1)]-3-chlorsulfonyl-4-chlorobenzoylamide
were filtered and dried at 100°C under vacuo, then was treated by ammonium
at room temperature. The obtained product was chromatographed (aluminum
oxide; eluent: chloroform-methanol 9:1 and methanol-ether) to give N-[cis-
2,6-dimethylpiperidyl-(1)]-3-sulfamyl-4-chlorbenzoylamide, melting point
235°-237°C. | [Brand name]
Aquex (Novartis). | [Therapeutic Function]
Diuretic, Antihypertensive | [storage]
Store at -20°C |
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