| Identification | More | [Name]
Pamidronate disodium salt | [CAS]
57248-88-1 | [Synonyms]
3-AMINO-1-HYDROXYPROPYLIDENE-BISPHOSPHONIC ACID, 2NA, PENTAHYDRATE
PAMIDRONATE
PAMIDRONATE, DISODIUM SALT, PENTAHYDRATE
(3-amino-1-hydroxypropylidene)bis-phosphonicacidisodiumsalt
(3-amino-1-hydroxypropylidene)diphosphonicaciddisodiumsalt
aminohydroxypropylidenediphosphonatedisodiumsalt
cgp23339a
disodium3-amino-1-hydroxypropylidene-1,1-biphosphonatepentahydrate
disodium dihydrogen (3-amino-1-hydroxypropylidene)bisphosphonate
PAMIDRONATE DISODIUM SALT HYDRATE
(3-AMINO-1-HYDROXYPROPYLIDINE)BIS-PHOSPHONIC ACID
Pamidronate Disodium, GCP-23339A, Aminomux, Aredia
Pamidronic Acid, Sodium Salt, Hydrate
Phosphonic acid, (3-amino-1-hydroxypropylidene)bis-, disodium salt
(3-amino-1-hydroxypropylidene)bis-phosphonic acid disodium salt
3-Amino-1-hydroxy-1-phosphonopropyl phosphonic acid disodium salt
Pamidronate disodium salt
PAMIDRONICDISODIUMSALT
(3-Amino-1-hydroxypropylidene)bisphosphonic Acid Disodium
3-Amino-1-hydroxy-1-phosphonopropanephosphonic acid hydrate disodium salt | [EINECS(EC#)]
260-647-1 | [Molecular Formula]
C3H19NNa2O12P2 | [MDL Number]
MFCD01938386 | [Molecular Weight]
369.11 | [MOL File]
57248-88-1.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R48:Danger of serious damage to health by prolonged exposure.
R41:Risk of serious damage to eyes.
R37/38:Irritating to respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S22:Do not breathe dust .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
3077 | [WGK Germany ]
3
| [RTECS ]
SZ6525000
| [HazardClass ]
IRRITANT | [HS Code ]
29319090 |
| Hazard Information | Back Directory | [Description]
Disodium pamidronate is a calcium metabolism regulator useful in the treatment of
hypercalcemia associated with malignancy. It presumably reduces the bone resorption of
calcium by inhibiting the formation and attachment of osteoclasts. Other potential uses
include osteoporosis and calcitonin-resistant Paget’s disease. | [Chemical Properties]
White Crystals | [Originator]
Henkel (United Kingdom) | [Uses]
A bisphosphonate antiresorptive agent; bone resorption inhibitor. | [Uses]
A farnesyl diphosphate synthase inhibitor | [Uses]
Pamidronate disodium is a nitrogen containing bisphosphonate, used to prevent osteoporosis. It is used to prevent bone loss, and treat osteoporosis. | [Manufacturing Process]
For a batch size of 5 L, 587.5 g (3.2 moles) of mannitol is dissolved in 3.5 L of water. Pamidronic acid (31.6 g, 0.133 moles) is mixed with a 1.0 L aliquot of the mannitol solution to form a slurry. The slurry is then transferred into the remainder of the mannitol solution, and stirred for at least 15 min. Aqueous 1 N sodium hydroxide (270 ml) is then added and the mixture is stirred until a clear, colorless solution results. The pH is then adjusted to 6.50.1 using either 1 M aqueous phosphoric acid or 1 N aqueous sodium hydroxide, as needed. The solution is then filtered through a 0.22 micron filter, and filled at 20°C into vials at 4.0 ml (4.172 g)/vial, under sterile conditions. The aqueous solution is frozen at -37°C and lyophilized (20 mbar, 20°-40°C) to yield 1,250 vials, each containing 30 mg of amorphous disodium pamidronate. The vials are sealed under positive nitrogen pressure. The disodium pamidronate is amorphous (noncrystalline) by X-ray diffraction and contains 0.7 wt-% water.
| [Brand name]
Aredia (Novartis). | [Therapeutic Function]
Bone resorption suppressant | [Biochem/physiol Actions]
Pamidronate disodium?has the ability to block Wnt and β-catenin signaling, which modulates the osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs). It can also reduce bilirubin-impaired apoptosis and helps to develop dentinogenic dysfunction of stem cells from human deciduous teeth. | [Veterinary Drugs and Treatments]
Pamidronate may be useful in treating hypercalcemia associated
with vitamin D-related toxicoses or hypercalcemia of malignancy.
There is ongoing research on the use of this drug to determine if
it has clinical usefulness in directly treating “micro-metastases” in
osteosarcomas.
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