| Identification | More | [Name]
Oxatomide | [CAS]
60607-34-3 | [Synonyms]
1-[3-[4-(DIPHENYLMETHYL)-1-PIPERAZINYL]PROPYL]-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE
OXATOMIDE
1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-1,3-dihydro-2h-benzimidazol-2
1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-2-benzimidazolinone
1,3-dihydro-1-(3-(4-(diphenylmethyl)-1-piperazinyl)propyl)-2h-benzimidazol-2-on
2h-benzimidazol-2-one,1,3-dihydro-1-(3-(4-(diphenylmethyl)-1-piperazinyl)propy
kw-4354
oxatimide
oxatomida
r35443
tinset
Celtect
Cobiona
Dasten
Tinse
1-[3-[4-(Diphmylmethyl)-1-piperazirlyI]propyl]-1，3-dihydro-2H-benzimidazol-2one
Cenacert
Fensedyl
KW-4354：McN-JR-35443
Truxa | [EINECS(EC#)]
262-320-9 | [Molecular Formula]
C27H30N4O | [MDL Number]
MFCD00211147 | [Molecular Weight]
426.55 | [MOL File]
60607-34-3.mol |
| Chemical Properties | Back Directory | [Appearance]
White Powder | [Melting point ]
153.60C | [Boiling point ]
541.98°C (rough estimate) | [density ]
1.1239 (rough estimate) | [refractive index ]
1.6000 (estimate) | [storage temp. ]
Refrigerator | [solubility ]
DMSO: soluble
| [form ]
White solid. | [pka]
12.20±0.30(Predicted) | [color ]
white
| [Usage]
Orally active anti-allergic agent; related structurally to cinnarizine and having a novel biphasic mode of action | [CAS DataBase Reference]
60607-34-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
DE2276000
| [Safety Profile]
Poison by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Experimental reproductive effects. Used to treat allergies and asthma. When heated to decomposition it emits toxic fumes of NOx. | [Toxicity]
LD50 in guinea pigs, mice, rats (mg/kg): 320, >2560, >2560 orally; 23, 27, 30 i.v. (Richards) |
| Hazard Information | Back Directory | [Chemical Properties]
White Powder | [Originator]
Tinset,Janssen,W. Germany ,1981 | [Uses]
Inhibits the release and actions of leukotrienes | [Uses]
Orally active anti-allergic agent; related structurally to cinnarizine and having a novel biphasic mode of action | [Uses]
Orally active anti-allergic agent; related structurally to cinnarizine and having a novel biphasic mode of action. | [Definition]
ChEBI: Oxatomide is a member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one substituted by a 3-[4-(diphenylmethyl)piperazin-1-yl]propyl group at position 1. It is an anti-allergic drug. It has a role as a geroprotector, a H1-receptor antagonist, an anti-allergic agent, an anti-inflammatory agent and a serotonergic antagonist. It is a N-alkylpiperazine, a member of benzimidazoles and a diarylmethane. | [Manufacturing Process]
A mixture of 53 parts of 1-(3chloropropyl)-2H-benzimidazol-2one, 5 parts of 1-(diphenylmethyl)piperazine, 6.4 parts of sodium bicarbonate and 200 parts of 4-methyl-2-pentanone is stirred and refluxed overnight with waterseparator. After cooling, water is added and the layers are separated. The 4methyl-2pentanone phase is dried, filtered and evaporated. The residue is purified by column-chromatography over silica gel using a mixture of trichloromethane and 5% of methanol as eluent. The pure fractions are collected and the eluent is evaporated. The oily residue is crystallized from a mixture of 2,2'-oxybispropane and a small amount of 2-propanol. The product is filtered off and dried, yielding 1-[3-[4-(diphenylmethyl)-1piperazinyl]propyl]-2H-benzimidazole-2-one; melting point 153.6°C.
| [Therapeutic Function]
Antiallergic | [Synthesis]
Oxatomide is synthesized
by alkylation of 1-diphenylmethylpiperazine
with 1-(3-chloropropyl)-1,3-dihydro-2Hbenzimidazol-
2-one in the presence of Na2CO3
. In addition to its histamine H1 receptor antagonistic
effect, oxatomide may have mast-cell
stabilizing activities . | [storage]
Store at -20°C |
|
| Company Name: |
Ralington Pharma
|
| Tel: |
+91-7948911722 +91-9687771722 |
| Website: |
www.ralingtonpharma.com |
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
| Company Name: |
Simagchem Corp.
|
| Tel: |
86 592 2680277 |
| Website: |
www.simagchem.com |
|