| Identification | More | [Name]
2-Mercaptoethanol | [CAS]
60-24-2 | [Synonyms]
2-HYDROXY-1-ETHANETHIOL
2-HYDROXYETHANETHIOL
2-HYDROXYETHYLMERCAPTAN
2-ME
2-MERCAPTHOETHANOL
2-MERCAPTOETHANOL
2-THIOETHANOL
BETA-MERCAPTOETHANOL
BME
HYDROXYETHYL MERCAPTAN
MERCAPTOETHANOL
MONOTHIOETHYLENE GLYCOL
THIOETHYLENE GLYCOL
THIOGLYCOL
?-hydroxyethanethiol
1-Ethanol-2-thiol
1-Hydroxy-2-mercaptoethane
1-Mercapto-2-hydroxyethane
2-Mercapitoethanol
2-mercapotethanol | [EINECS(EC#)]
200-464-6 | [Molecular Formula]
C2H6OS | [MDL Number]
MFCD00004890 | [Molecular Weight]
78.13 | [MOL File]
60-24-2.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear colorless liquid | [Melting point ]
-100 °C | [Boiling point ]
157 °C (lit.) | [density ]
1.115 g/mL at 20 °C
| [vapor density ]
2.69 (vs air)
| [vapor pressure ]
1 mm Hg ( 20 °C)
| [FEMA ]
4582 | 2-HYDROXYETHANETHIOL | [refractive index ]
n20/D 1.500(lit.)
| [Fp ]
165 °F
| [storage temp. ]
2-8°C
| [solubility ]
H2O: 1 mL/mL
| [form ]
liquid
| [pka]
9.72(at 25℃) | [color ]
Clear colorless to slightly yellow | [Specific Gravity]
1.119 (20/4℃) | [Odor]
Disagreeable odor | [PH]
4.5-6 (500g/l, H2O, 20℃) | [PH Range]
4.5 - 6 at 500 g/l at 20 °C | [explosive limit]
2.3-18%(V) | [Water Solubility ]
soluble | [FreezingPoint ]
<100℃ | [Sensitive ]
Air Sensitive & Hygroscopic | [λmax]
λ: 260 nm Amax: 1.5
λ: 280 nm Amax: 0.3 | [JECFA Number]
1925 | [Merck ]
14,5869 | [BRN ]
773648 | [Stability:]
Air Sensitive | [LogP]
-0.20 | [CAS DataBase Reference]
60-24-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Ethanol, 2-mercapto-(60-24-2) | [EPA Substance Registry System]
60-24-2(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T,N | [Risk Statements ]
R20/22:Harmful by inhalation and if swallowed .
R24:Toxic in contact with skin.
R34:Causes burns.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R36/37/38:Irritating to eyes, respiratory system and skin .
R22:Harmful if swallowed.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S29:Do not empty into drains .
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S27:Take off immediately all contaminated clothing . | [RIDADR ]
UN 2966 6.1/PG 2
| [WGK Germany ]
3
| [RTECS ]
KL5600000
| [F ]
3-10-13-23 | [Autoignition Temperature]
295 °C | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
II | [HS Code ]
29309070 | [Safety Profile]
Poison by ingestion,
skin contact, and intraperitoneal routes.
Moderately toxic by intravenous route. A
skin and severe eye irritant. Human
mutation data reported. A combustible
liquid when exposed to heat, flame, or
oxidizers. To fight fire, use alcohol foam,
CO2, dry chemical. When heated to
decomposition it emits highly toxic fumes of
SOx. See also MERCAPTANS. | [Hazardous Substances Data]
60-24-2(Hazardous Substances Data) |
| Hazard Information | Back Directory | [General Description]
A water-white liquid. May be toxic by ingestion, inhalation, or skin absorption. | [Reactivity Profile]
Organosulfides, such as THIOGLYCOL(60-24-2), are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. | [Air & Water Reactions]
No rapid reaction with air. No rapid reaction with water. | [Hazard]
Toxic by inhalation and ingestion. | [Health Hazard]
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. | [Fire Hazard]
Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. | [Chemical Properties]
Clear colorless liquid. 2-mercaptoethanol (bME) is a popular effective reducer, but extremely pungent. | [Uses]
2-Mercaptoethanol is used in the synthesis of nano-graphene for cellular imaging and drug delivery. Also used in the synthesis of multifunctional polymeric micelle used in specific targeting of tumor disruption. | [Uses]
Solubilizes proteins by reducing disulfide linkages2-Mercaptoethanol is used in the preparation of nano-graphene for cellular imaging and drug delivery as well as multifunctional polymeric micelle. It acts as a reducing agent used in electrophoresis, amino acid detection, and distinguishing ssDNA/dsDNA. It is also employed as a standard buffer. It is also used in the preparation of PVC heat stabilizers and as a chain transfer agent in the manufacture of PVC. Further, it is used in some RNA isolation procedures to eliminate ribonuclease. It is utilized as a corrosion inhibitor and ore floatation agent. In biochemistry, it is useful to study the activity of the immune system. | [Application]
2-Mercaptoethanol is used in the synthesis of nano-graphene for cellular imaging and drug delivery. Also used in the synthesis of multifunctional polymeric micelle used in specific targeting of tumor disruption. | [Definition]
ChEBI: 2-Mercaptoethanol is a primary alcohol and an alkanethiol. It has a role as a geroprotector. | [Purification Methods]
Purify it by distilling in a vacuum. Distilling at atmospheric pressure causes some oxidation and should be done in an inert atmosphere. [Woodward J Chem Soc 1892 1948.] It has a foul odour, is irritating t o the eyes, nose and skin — should be handled in an efficient fume cupboard. It is miscible with H2O, EtOH, Et2O and *C6H6 and the UV has max at 235nm. The 2,4-dinitrophenyl thioether has m 101-102o (from EtOH or aqueous MeOH) [Grogen et al. J Org Chem 20 50 1955]. [Beilstein 1 IV 2428.] |
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