| Identification | More | [Name]
Alizapride | [CAS]
59338-93-1 | [Synonyms]
ALIZAPRIDE
n-(1-allyl-2-pyrrolidinylmethyl)-6-methoxy-1h-benzotriazole-5-carboxamide
1h-benzotriazole-5-carboxamide,6-methoxy-n-((1-(2-propenyl)-2-pyrrolidinyl)met
6-methoxy-n-((1-(2-propenyl)-2-pyrrolidinyl)methyl)-1h-benzotriazole-5-carbo
6-Methoxy-N-{[1-(2-propnyl)-2-pyrrolidinyl]methyl]-1H-benzotriazole-5-carboxamide
Litican
Nausilen
Plitican
Vergentan
6-Methoxy-N-[[1-(2-propenyl)-2-pyrrolidinyl]methyl]-1H-benzotriazole-5-carboxamide
MS-5080 | [EINECS(EC#)]
261-710-6 | [Molecular Formula]
C16H21N5O2 | [MDL Number]
MFCD00867757 | [Molecular Weight]
315.37 | [MOL File]
59338-93-1.mol |
| Hazard Information | Back Directory | [Originator]
Plitican ,Delagrange ,France ,1981 | [Definition]
ChEBI: 6-methoxy-N-[(1-prop-2-enyl-2-pyrrolidinyl)methyl]-2H-benzotriazole-5-carboxamide is a member of benzotriazoles. | [Manufacturing Process]
38.6 g (0.2 mol) of 2-methoxy-4,5-azimidobenzoic acid were dissolved in
anhydrous toluene and 56 g (0.4 mol) of 1-allyl-2-amino-methylpyrrolidine
were added. The mixture was heated to 50°C and then 42 g (0.3 mol) of
phosphoric anhydride were added. The mixture was warmed at reflux
temperature for 3 hours and then cooled to 80°C. After adding water, the
aqueous layer was alkalized. The crystals were filtered, washed with water
and then dissolved in 450 ml of acetone. After crystallization, the product was 40.4 g (yield 65%) of N-(1'-allyl-2'-pyrrolidylmethyl)-2-methoxy-4,5-
azimidobenzamide having a melting point of 139°C were obtained. | [Therapeutic Function]
Neuroleptic, Antiemetic |
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