| Identification | More | [Name]
6-Acetamidohexanoic acid | [CAS]
57-08-9 | [Synonyms]
6-ACETAMIDOHEXANOIC ACID
6-ACETAMINOHEXANOIC ACID
EPSILON-ACETAMIDOCAPROIC ACID
6-acetylaminocaproicacid
Acexamic Acid
6-ACETAMIDOHEXANOIC ACID 99%
6-(Acetylamino)hexanoic acid
6-Acetamidocaproic acid
Acetaminocaproic acid
CY 153
Plastenan | [EINECS(EC#)]
200-310-8 | [Molecular Formula]
C8H15NO3 | [MDL Number]
MFCD00004424 | [Molecular Weight]
173.21 | [MOL File]
57-08-9.mol |
| Chemical Properties | Back Directory | [Appearance]
WHITE POWDER | [Melting point ]
102-104 °C(lit.)
| [Boiling point ]
303.86°C (rough estimate) | [density ]
1.1599 (rough estimate) | [refractive index ]
1.4590 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Sparingly), Methanol (Slightly) | [form ]
Solid | [pka]
4.75±0.10(Predicted) | [color ]
White to Off-White | [Merck ]
14,45 | [LogP]
-0.500 (est) | [CAS DataBase Reference]
57-08-9(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
WHITE POWDER | [Originator]
Acexamic acid ,Flamma | [Uses]
6-Acetamidohexanoic acid is used after oral administration of an antiulcer agent, zinc acexamate (ZAC) for treatment of gastric ulcer or small bowel inflammation. | [Uses]
wound healing agent | [Definition]
ChEBI: Acexamic acid is a medium-chain fatty acid. | [Manufacturing Process]
400 L of demineralized water, 5.0 kg of calcium hydroxide, and 155.0 kg
(1000 moles) of acetyl-caprolactame are introduced under stirring and at a
temperature of about 25°C into a 1000 L stainless double walled reactor.
The temperature is raised to 30°C. 75.0 kg of calcium hydroxide are
introduced stepwise in the form of successive amounts of 2.0 kg each in the
medium, under stirring and at a temperature adjusted and maintained 25°-
30°C through external cooling, in a manner such that the time required to
introduce into the reactor the whole amount of calcium hydroxide
approximates 1.5 h. When the stirring is stopped, the pH is about 7.5-7.8.
The obtained mixture is stirred continuously at a temperature of 30°C during
14 h. At the end of this operation the pH is again adjusted at a value 7.5-7.8.
The hydrolysate is filtered on a 60 x 60 pressfilter comprising 6 compartments
and equipped with fabrics of the polyester known under the designation
TERGAL which have been previously coated with a suspension of a cellulose
commercialized under the trademark SOLKA FLOX BW20. The duration of
filtration is of 1.5 h. 580 L of the filtrate are recovered and subjected to a
concentration under reduced pressure in an evaporator the volume of which is
of 750 L, at a distillation temperature ranging from 45°-50°C under a reduced
pressure of 10-15 Torr.
The operation is ran until concentration of the solution to 280 L, the
concentrated solution being then left standing. The crystallisation is already
considerable 2 h after the end of the operation of concentration.
Crystallisation is ended after 16-24 h.
The crystals are centrifuged at a speed of 700 revolutions/minute. The
centrifuged crystals of calcium acexamate are washed twice on the centrifuge
with 20 l of acetone. 107.0 kg of crystals are obtained, which are dried under
vacuum at 40°C. The 96.0 kg of dry calcium acexamate obtained are ground
and sifted.
Acexamic acid may be produced by treatment of the calcium acexamate with
HCl. | [Therapeutic Function]
Antifibrinolytic |
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