| Identification | More | [Name]
Rilmenidine | [CAS]
54187-04-1 | [Synonyms]
n-(dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine
oxaminozoline
RILMENIDINE
1,1-dicyclopropyl-n-(2-oxazolinyl)-methylamin
2-((dicyclopropylmethyl)imino)-oxazolidin
2-((dicyclopropylmethyl)imino)oxazolidine
2-(dicyclopropylmethylamino)-2-oxazoline
4,5-dihydro-n-(dicyclopropylmethyl)-2-oxazolamin
s3341
N-(dicyclopropylmethyl)-4,5-dihydrooxazol-2-amine
2-(N-(Dicyclopropylmethyl)amino)oxazolinehemifuramate
Rilmenidinehemifuramate
Rilmenidine 2-[(Dicyclopropylmethyl)amino]-2-oxazoline
Hyperium
S-3341-3
2-[N-(Dicyclopropylmethyl)amino]oxazoline fumarate (2:1) salt
N-(2-Oxazolin-2-yl)-α,α-dicyclopropylmethanamine | [EINECS(EC#)]
259-021-0 | [Molecular Formula]
C10H16N2O | [MDL Number]
MFCD00865924 | [Molecular Weight]
180.25 | [MOL File]
54187-04-1.mol |
| Safety Data | Back Directory | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [RTECS ]
RP7207400
|
| Hazard Information | Back Directory | [Description]
Rilmenidine is a new antihypertensive agent with a selective alphaz-agonist/antagonist
profile, reportedly useful in the management of mild to moderate hypertension. Its
fmt-line indication is possible because of the clear dissociation of its antihypertensive
activity from other neurophannacological effects. | [Chemical Properties]
water soluble | [Originator]
Servier (France) | [Uses]
I1-imidazoline binding site ligand and a2-adrenoceptor agonist, exhibits higher I1 vs. a2 selectivity than clonidine | [Definition]
ChEBI:Rilmenidine is an isourea. | [Brand name]
Hyperium | [Biological Activity]
I 1 -imidazoline binding site selective ligand and α 2 -adrenoceptor agonist. Possesses greater I 1 vs α 2 selectivity than the prototypical compound, clonidine. | [Metabolic pathway]
In short-term rat hepatocyte cultures, oxaminozoline is
metabolized and its four metabolites resulting from
oxidation or hydrolysis are identified, three of which
are identical to those reported in vivo. The presence of
an additional minor metabolite in culture may be due
to the higher metabolic rate of oxaminozoline in this
model system. |
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