| Identification | More | [Name]
Ammonium 1-pyrrolidinedithiocarbamate | [CAS]
5108-96-3 | [Synonyms]
1-PYRROLIDINECARBODITHIOIC ACID
1-PYRROLIDINECARBODITHIOIC ACID, AMMONIUM SALT
1-PYRROLIDINEDITHIOCARBOXYLIC ACID, AMMONIUM SALT
AMMONIUM 1-PYRROLIDINECARBODITHIOATE
AMMONIUM 1-PYRROLIDINEDITHIOCARBAMATE
AMMONIUM PYRROLIDINECARBODITHIOATE
AMMONIUM PYRROLIDINEDITHIOCARBAMATE
AMMONIUM PYRROLIDINEDITHIOCARBAMATE AMMONIUM SALT
AMMONIUM PYRROLIDINE DITHIOFORMATE
AMMONIUM PYRROLIDINE-N-DITHIOCARBAMATE
AMMONIUM PYRROLIDINO-DITHIOCARBAMATE
AMMONIUM PYRROLIDINODITHIOCARBOXYLATE
AMMONIUM TETRAMETHYLENE DITHIOCARBAMATE
APCD
APDC
APDC AMMONIUM SALT
APDTC
APDTC AMMONIUM SALT
N,N-TETRAMETHYLENEDITHIOCARBAMIC ACID AMMONIUM SALT
PDTC, NH4 | [EINECS(EC#)]
225-834-4 | [Molecular Formula]
C5H13N3S2 | [MDL Number]
MFCD00012720 | [Molecular Weight]
179.31 | [MOL File]
5108-96-3.mol |
| Chemical Properties | Back Directory | [Appearance]
pale yellow crystalline solid | [Melting point ]
153-155 °C(lit.)
| [density ]
1.117 (estimate) | [refractive index ]
1.5300 (estimate) | [storage temp. ]
2-8°C
| [solubility ]
190g/l | [form ]
Powder/Solid | [color ]
White to off-white | [PH]
6-7 (50g/l, H2O, 20℃) | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
50 g/L (20 ºC) | [Sensitive ]
Hygroscopic | [BRN ]
3730472 | [CAS DataBase Reference]
5108-96-3(CAS DataBase Reference) | [EPA Substance Registry System]
5108-96-3(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R22:Harmful if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [F ]
3 | [TSCA ]
Yes | [HS Code ]
29339990 |
| Hazard Information | Back Directory | [Description]
Pyrrolidinedithiocarbamic acid (PDTC) is a metal chelating compound that potently and reversibly inhibits NF-κB activation in vitro (100 μM).1 At 300 μM, it prevents TNF-α gene expression and protein production in human monocytes after LPS application.2 In vascular smooth muscle cells, PDTC (10 μM) arrests the cell cycle at the G1 phase with upregulation of p21Cip1 through the p38 MAPK pathway.3 PDTC (100 μM) also has antioxidant properties.4 | [Chemical Properties]
pale yellow crystalline solid | [Uses]
1-Pyrrolidinecarbodithioic Acid induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells. It also prevents induction of nitric oxide synthetase by inhibiting translation of NOS mRNA; | [General Description]
Ammonium pyrrolidinedithiocarbamate is a nuclear factor κB (NF-κB) inhibitor. It functions as a chelating agent, which allows the preconcentration of trace metals from solution. Pyrrolidinedithiocarbamate (PDTC) has antioxidant properties. It inhibits apoptosis in lymphocytes, neurons and vascular endothelial cells. | [Biochem/physiol Actions]
Prevents induction of nitric oxide synthetase by inhibiting translation of NOS mRNA; induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells. | [Purification Methods]
Purify the salt by recrystallising twice by dissolving in MeOH and adding Et2O. It has also been purified by recrystallisation from EtOH. It is used for the precipitation of As, Bi, Cd, Co, Cu, Fe, Mn, Ni, Pb, Sb, Su, V and Zn from acidic solutions [Kinrade & van Loon Anal Chem 46 1894 1974]. The ethyl ester has b 87-89o/0.01mm. [Synthesis and Polarography: Kitagawa & Taku Bull Chem Soc Jpn 64 2151 1973, Malissa & Sch.ffmann Mikrochim Acta 187 1955, Beilstein 20 III/IV 195, 20/1 V 331.] |
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