| Identification | More | [Name]
Tolperisone hydrochloride | [CAS]
3644-61-9 | [Synonyms]
2,4'-dimethyl-3-piperidinopropiophenone
2,4'-DIMETHYL-3-PIPERIDINOPROPIOPHENONE HYDROCHLORIDE
2,4'-dimethyl-3-piperidinopropiophenone monohydrochloride
2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanone
4'-METHYL-2-(1-PIPERIDINYLMETHYL)-PROPIOPHENONE HCL
4'-methyl-2-(1-piperidinylmethyl)-propiophenone hydrochloride
LABOTEST-BB LT00772344
TOLPERISONE HCL
TOLPERISONE HYDROCHLORIDE
1-piperidino-2-methyl-3-(p-tolyl)-3-propanonehydrochloride
2,4’-dimethyl-3-piperidino-propiophenonhydrochloride
2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanonhydrochloride
2-methyl-3-piperidino-1-p-tolylpropan-1-onehydrochloride
midocalm
muscalm
mydocalm
n-553
1-Piperidino-2-methyl-3-(4-methylphenyl)propan-3-one hydrochloride
1-Propanone, 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-, hydrochloride (9CI)
Abbsa | [EINECS(EC#)]
222-876-5 | [Molecular Formula]
C16H24ClNO | [MDL Number]
MFCD00058211 | [Molecular Weight]
281.82 | [MOL File]
3644-61-9.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S36/37:Wear suitable protective clothing and gloves .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3 | [RTECS ]
UH1575500 | [Toxicity]
LD50 s.c. in mice: 620 mg/kg (Porszasz, 1961) |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Originator]
Tolperisone hydrochloride,Shanghai Abochem
Chemical Co. | [Uses]
Tolperisone hydrochloride can be used as a muscle relaxant.
| [Definition]
ChEBI: Tolperisone hydrochloride is an aromatic ketone. | [Manufacturing Process]
To 1-(4-methylphenyl)-3-(1-piperidinyl)-1-propanol in chloroform was added
an excess of thionyl chloride and the reaction mixture refluxed until
completed. It was then taken to dryness under reduced pressure and the
residue crystallized by dissolving in hot alcohol and diluting with ethyl acetate.
An aqueous solution of the obtained N-[3-chloro-3-(p-tolyl)propyl]piperidine
hydrochloride was hydrogenated at 3 atmospheres in the presence of buffered
palladium-on-charcoal catalyst. 1-Piperidino-2-methyl-3-(p-tolyl)-3-propanone
was purified by distilling the base (boiling point 106-107°C/1 mm) and
reconverting to the hydrochloride, melting point 216-217°C. | [Therapeutic Function]
Muscle relaxant, Vasodilator | [Biochem/physiol Actions]
Tolperisone is derived from piperidine and possesses membrane stabilizing action. It helps in reducing the effect of spasticities associated with the nervous and muscular system. It exhibits muscle relaxant action through attenuating voltage-gated sodium channels in the brain stem. |
|
|