| Identification | Back Directory | [Name]
2'-Deoxy-L-thymidine | [CAS]
3424-98-4 | [Synonyms]
Ldt
L-Dt
NV 02B
Sebivo
Epavudine
Aids112549
Aids-112549
L-Deoxythymidine
BETA-L-THYMIDINE
Telbivudine, >=98%
2'-DEOXY-L-THYMIDINE
β-L-2'-deoxy-thyMidine
L-Thymidine(Telbivudine)
Telbivudine(L-ThyMidine)
Telbivudine(Tyzeka, Sebivo)
Telbivudine(L-ThyMidine,LDT-600)
2'-Deoxy-L-thyMidine(Telbivudine)
1-(2-deoxy--L-erythro-pentofuranosyl)thymine
1-(2-Deoxy-β-L-erythro-pentofuranosyl)-5-Methyl-
Thymine, 1-(2-deoxy-.beta.-L-erythro-pentofuranosyl)-
1-(2-Deoxy--L-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
2,4(1H,3H)-PyriMidinedione,1-(2-deoxy-b-L-erythro-pentofuranosyl)-5-Methyl-
1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)oxolan-2-yl]-5-Methyl-1,2,3,4-tetrahydropyriMidine-2,4-dione | [EINECS(EC#)]
608-961-3 | [Molecular Formula]
C10H14N2O5 | [MDL Number]
MFCD02683612 | [MOL File]
3424-98-4.mol | [Molecular Weight]
242.23 |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
188-190°C | [alpha ]
D20 -20.3° (c = 0.192 in water) | [density ]
1.452±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
H2O: soluble10mg/mL (clear solution) | [form ]
powder | [pka]
9.55±0.10(Predicted) | [color ]
white to beige | [optical activity]
[α]/D -15 to -22°, c = 1 in H2O | [InChIKey]
IQFYYKKMVGJFEH-CSMHCCOUSA-N |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Nucleoside analog; specific inhibitor of hepatitis B virus (HBV) replication. Antiviral | [Uses]
Telbivudine(Tyzeka, Sebivo) is an antiviral drug used in the treatment of hepatitis B infection. Clinical trials have shown it to be significantly more effective than lamivudine or adefovir, and less likely to cause resistance. Telbivudine is a synthetic | [Definition]
ChEBI: A pyrimidine 2'-deoxyribonucleoside that is the L-enantiomer of thymine. A synthetic thymidine nucleoside analogue with activity against HBV DNA polymerase. | [Description]
Telbivudine is a b-L-thymidine nucleoside analog launched for the
once-daily oral treatment of chronic hepatitis B virus (HBV) infection. It is
the fourth nucleoside or nucleotide analog to be marketed for this indication. The
previous drugs from this class include lamivudine, a deoxythiacytosine analog,
adefovir, a nucleotide analog, and entecavir, a guanosine analog. Adefovir, entecavir,
and telbivudine are specifically indicated for HBV, whereas lamivudine is indicated for both HBV and HIV infections. Telbivudine is efficiently phosphorylated
by cellular kinases to the active triphosphate derivative, which
inhibits HBV DNA polymerase by competing with the natural substrate, thymidine-
5’-triphosphate. | [Originator]
Idenix (US) | [Brand name]
(Novirio). |
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