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ChemicalBook--->CAS DataBase List--->29925-17-5

29925-17-5

29925-17-5 Structure

29925-17-5 Structure
IdentificationMore
[Name]

RO 20-1724
[CAS]

29925-17-5
[Synonyms]

ro 20-172
RO 20-1724
Ro-20-1724 - CAS 29925-17-5 - Calbiochem
4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDONE
4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDINONE
4-(3-BUTOXY-4-METHOXY-BENZYL)IMIDAZOLIDIN-2-ONE
4-(3-BUTOXY-4-METHOXYPHENYL)METHYL-2-IMIDAZOLIDONE
4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one solid
4-[(3-BUTOXY-4-METHOXYPHENYL)METHYL]-2-IMIDAZOLIDINONE
4-[(3-Butoxy-4-methoxyphenyl)methyl]imidazolidin-2-one
2-Imidazolidinone, 4-[(3-butoxy-4-methoxyphenyl)methyl]-
[Molecular Formula]

C15H22N2O3
[MDL Number]

MFCD00077397
[Molecular Weight]

278.35
[MOL File]

29925-17-5.mol
Chemical PropertiesBack Directory
[storage temp. ]

room temp
[solubility ]

ethanol: 7 mg/mL
[form ]

solid
[color ]

White
[Stability:]

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months.
[CAS DataBase Reference]

29925-17-5(CAS DataBase Reference)
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

RO 20-1724 (29925-17-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 0.2 μM. Displays anti-inflammatory activity. Cell permeable
[Uses]

Ro 20-1724 is a cell-permeable, cAMP-specific phosphodiesterase type IV (PDE4) inhibitor (IC50 = 2 μM). It weakly inhibits PDE3 with a Ki value greater than 25 μM. Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species. It is often used to study cAMP-related functions in vascular cells.
[Uses]

Ro 20-1724 Is an inhibitor of phosphodiesterase-4, and also very effective for patients with plaque psoriasis. Selective inhibitor of cAMP-specific phosphodiesterase. Selective PDE4 inhibitor.
[Definition]

ChEBI: 4-[(3-butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone is a member of methoxybenzenes.
[Biological Activity]

Widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC 50 = 2.0 μ M). Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .
[Biochem/physiol Actions]

Inhibitor of cAMP phosphodiesterase. IC50 33 μM in vascular smooth muscle of the aorta.
[storage]

Store at- 20°C
[References]

1) Soderling et al. (1998), Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase; Proc. Natl. Acad. Sci. USA, 95 8991 2) Nicholson et al. (1991), Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes; Trends Pharmacol. Sci., 12 19
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

29925-17-5(sigmaaldrich)
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