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ChemicalBook--->CAS DataBase List--->433695-36-4

433695-36-4

433695-36-4 Structure

433695-36-4 Structure
IdentificationBack Directory
[Name]

BRL 50481
[CAS]

433695-36-4
[Synonyms]

BRL 50481
5-NITRO-2,N,N-TRIMETHYLBENZENESULFONAMIDE
N,N,2-TRIMETHYL-5-NITRO-BENZENESULFONAMIDE
Benzenesulfonamide, N,N,2-trimethyl-5-nitro-
3-(N,N-Dimethylsulfonamido)-4-methylnitrobenzene,5-Nitro-2-N,N-trimethylbenzenesulfonamide
[EINECS(EC#)]

1592732-453-0
[Molecular Formula]

C9H12N2O4S
[MDL Number]

MFCD03039912
[MOL File]

433695-36-4.mol
[Molecular Weight]

244.27
Chemical PropertiesBack Directory
[Appearance]

Off-White Solid
[Melting point ]

65-67°C
[Boiling point ]

391.1±52.0 °C(Predicted)
[density ]

1.334±0.06 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

DMSO: 12 mg/mL
[form ]

solid
[pka]

-5?+-.0.70(Predicted)
[color ]

white
[Stability:]

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Hazard InformationBack Directory
[Chemical Properties]

Off-White Solid
[Uses]

A PDE7 inhibitor that has acceptable selectivity for in vivo studies
[Biological Activity]

Selective, substrate-competitive inhibitor of phosphodiesterase (PDE) 7 (K i = 180 nM). Displays > 200-fold selectivity over PDE1B, PDE1C, PDE2, PDE3, PDE4A4 and PDE5.
[Description]

BRL-50481 (433695-36-4) is a potent and selective inhibitor of phosphodiesterase-7 (PDE7), Ki=180 nM.1?Induces apoptosis in chronic lymphocytic leukemia cells which express PDE7B.2?BRL-50481 increases mineralization in osteoblasts differentiated from hMSC.3?Cell permeable.
[Definition]

ChEBI: BRL-50481 is a C-nitro compound that is benzene substituted by N,N-dimethylaminosulfonyl, methyl and nitro groups at positions 1, 2 and 5, respectively. It is a phosphodiesterase inhibitor selective for the PDE7 subtype (Ki = 180 nM). It has a role as an EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor, a geroprotector and a bone density conservation agent. It is a sulfonamide, a C-nitro compound and a member of toluenes.
[Biochem/physiol Actions]

BRL 50481 is a potent and selective PDE7 inhibitor (IC50 = 260 nM).
[storage]

Store at +4°C
[References]

1) Smith et al. (2004), Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages and CD8+ T-lymphocytes; Mol. Pharmacol., 66 1679 2) Zhang et al. (2008), Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia; Proc. Natl. Acad. Sci. USA 105 19532 3) Pekkinen et al. (2008), Effects of phosphodiesterase 7 inhibition by RNA interference on the gene expression and differentiation of human mesenchymal stem cell-derived osteoblasts; Bone 43 84
Safety DataBack Directory
[WGK Germany ]

3
[HS Code ]

2935.90.9500
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