| Identification | More | [Name]
Choline glycerophosphate | [CAS]
28319-77-9 | [Synonyms]
CHOLINE ALFOSCERATE
GLYCEROPHOSPHORYLCHOLINE
GPC
L-ALPHA-GLYCEROPHOSPHORYLCHOLINE
L-ALPHA-GLYCEROPHOSPHORYLCHOLINE INNER SALT
L-ALPHA-GLYCERYLPHOSPHORYLCHOLINE
SN-3-GLYCEROPHOSPHOCHOLINE
SN-GLYCERO-3-PHOSPHOCHOLINE
SN-GLYCERO-3-PHOSPHOCHOLINE INNER SALT
SN-GLYCEROPHOSPHORYLCHOLINE (EGG)
,hydroxide,innersalt,(r)-
2-(((2,3-dihydroxypropoxy)hydroxyphosphinyl)oxy)-n,n,n-trimethyl-ethanaminiu
glycerophosphocholine
hydroxide,2,3-dihydroxypropylhydrogenphosphate,innersalt,d-cholin
l-alpha-glycerophosphocholine
L-A-glycerophosphorylcholine from*egg yolk free F
L-a-Glycerophosphorylcholine (choline alfoscerate) (GPC)
L-a-Glycerophosphorylcholine (anhydrous) (GPC)
L-A-GLYCEROPHOSPHORYLCHOLINE FROM*EGG YOLK FREE FORM
L-A-GLYCEROPHOSPHORYLCHOLINE FROM SOYBEAN, FREE FORM | [EINECS(EC#)]
248-962-2 | [Molecular Formula]
C13H35N2O8P | [MDL Number]
MFCD00063544 | [Molecular Weight]
378.4 | [MOL File]
28319-77-9.mol |
| Chemical Properties | Back Directory | [Appearance]
White waxy solid | [Melting point ]
142.5-143° | [alpha ]
D25 -2.7° (c = 2.7 in water, pH 2.5); D25 -2.8° (c = 2.6 in water, pH 5.8) | [Boiling point ]
480℃[at 101 325 Pa] | [vapor pressure ]
0Pa at 25℃ | [Fp ]
11 °C | [storage temp. ]
−20°C
| [solubility ]
DMSO (Slightly, Heated, Sonicated), Methanol (Sparingly), Water (Sparingly) | [form ]
solid
| [color ]
White to Off-White | [Water Solubility ]
1000g/L at 25℃ | [Stability:]
Very Hygroscopic | [InChI]
InChI=1/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/t8-/s3 | [InChIKey]
SUHOQUVVVLNYQR-SBYBRXNCNA-N | [SMILES]
P([O-])(=O)(OCC[N+](C)(C)C)OC[C@H](O)CO |&1:12,r| | [LogP]
-5.15 at 25℃ | [CAS DataBase Reference]
28319-77-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
F,T | [Risk Statements ]
R11:Highly Flammable.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S16:Keep away from sources of ignition-No smoking .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 1230 3/PG 2
| [WGK Germany ]
2
| [RTECS ]
KH2775000
| [HS Code ]
29239000 |
| Hazard Information | Back Directory | [Description]
Choline alfoscerate is a nootropic reportedly effective in the treatment of age-associated
memory impairment. In man, it decreased and prevented scopolamine-induced
amnesia. In vitro studies suggest that choline alfoscerate acts indirectly on cholinergic
transmission by elevating the synthesis of acetylcholine. | [Chemical Properties]
White waxy solid | [Originator]
Sandoz; Italfarmaco (Italy) | [Uses]
sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a phospholipid; precursor in choline biosynthesis. sn-Glycero-3-phosphocholine is an intermediate in catabolic pathway of phosphatidylcholine. sn-Glycero-3-phosphocholine is used as an Nootropic. | [Definition]
ChEBI: A member of the class of phosphocholines that is the choline ester of sn-glycero-3-phosphate. It is one of the major osmolyte in the renal medullary cells. | [Brand name]
Delecit | [General Description]
L-α-Glycerophosphorylcholine is a phospholipid, which is a derivative of phosphatidylcholine. | [Flammability and Explosibility]
Notclassified | [Biochem/physiol Actions]
Increases inositol phosphate formation. | [Synthesis]
10 g of phosphorylcholine chloride (1 equivalent, 228 mmol) was dissolved in 200 ml of methanol in a 500 ml three-necked round bottom flask equipped with a thermometer, a reflux condenser and a stirrer. Then, 5.1 g of potassium hydroxide (2 equivalents, 455 mmol) Lt; / RTI & gt; stirred for 1 hour. After warming the reaction to 65 ° C, 10 g of (R) -3-chloro-1,2-propanediol (2 eq, 452 mmol) was added slowly and refluxed for 16 hours to carry out the substitution reaction. After completion of the reaction, 10 ml of water was added to the concentrate obtained by concentration under reduced pressure, and the reaction product was diluted with acetone twice. The aqueous layer was concentrated under reduced pressure to obtain 11.60 g of L-α-glycerophosphorylcholine (sn-Glycero-3-phosphocholine; yield: 99%).
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