| Identification | More | [Name]
5-Chlorothiophene-2-sulfonyl chloride | [CAS]
2766-74-7 | [Synonyms]
5-CHLORO-2-THIENYLSULFONYL CHLORIDE
5-CHLORO-2-THIOPHENESULFONYL CHLORIDE
5-CHLOROTHIOPHENE-2-SULFONYL CHLORIDE
5-CHLOROTHIOPHENE-2-SULPHONYL CHLORIDE
5-CHLOROTHIOPHENESULPHONYL CHLORIDE
AKOS B019398
ART-CHEM-BB B019398
BUTTPARK 27\04-09
TIMTEC-BB SBB003378
5-CHLOROTHIOPHENE-2-SULFONYL CHLORIDE, 9
5-Chlorothiophene-2-sulfonylchloride,97%
5-chlorothiophene-2-sulfonyl
5-CHLOROTHIOPHENESULFONYLCHLORIDE,96%
5-Chlorothiophene-2-sulfonyl chloride ,98%
5-Chlorothiophene-2-sulfonic acid chloride | [Molecular Formula]
C4H2Cl2O2S2 | [MDL Number]
MFCD00051667 | [Molecular Weight]
217.09 | [MOL File]
2766-74-7.mol |
| Chemical Properties | Back Directory | [Appearance]
white to yellow crystalline low melting solid | [Melting point ]
25-28°C | [Boiling point ]
112-117 °C (lit.) | [density ]
1.623 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.586(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Keep Cold | [form ]
solid | [Specific Gravity]
1.623 | [Water Solubility ]
Not miscible in water. | [Sensitive ]
Moisture Sensitive | [Detection Methods]
HPLC | [BRN ]
130710 | [InChIKey]
SORSTNOXGOXWAO-UHFFFAOYSA-N | [CAS DataBase Reference]
2766-74-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns.
R29:Contact with water liberates toxic gas.
R14:Reacts violently with water. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S27:Take off immediately all contaminated clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S25:Avoid contact with eyes . | [RIDADR ]
UN 3265 8/PG 2
| [WGK Germany ]
3
| [Hazard Note ]
Corrosive | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29349990 |
| Hazard Information | Back Directory | [Chemical Properties]
5-Chlorothiophene-2-sulfonyl chloride is white to yellow crystalline low melting solid
| [Uses]
5-Chloro-2-thiophenesulfonyl Chloride is a sulfonylthiophene derivative used in the preparation of Notch-1-sparing γ-secretase inhibitors for the treatment of Alzheimer's disease. | [Uses]
5-Chlorothiophene-2-sulfonyl chloride is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuffs. It is used in the preparation of Notch-1-sparing γ-secretase inhibitors for the treatment of Alzheimer's disease. | [Synthesis Reference(s)]
Tetrahedron, 21, p. 1333, 1965 DOI: 10.1016/S0040-4020(01)98293-6 | [General Description]
5-Chlorothiophene-2-sulfonyl chloride can be prepared from 2-chlorothiophene by reacting with chlorosulfonic acid in the presence of phosphorus pentachloride. |
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