| Identification | Back Directory | [Name]
Benzenesulfonamide, 4-[[[5-bromo-2-[[3-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl]amino]-4-pyrimidinyl]amino]methyl]- | [CAS]
2361659-62-1 | [Synonyms]
GSK8612;GSK-8612;GSK 8612
Benzenesulfonamide, 4-[[[5-bromo-2-[[3-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl]amino]-4-pyrimidinyl]amino]methyl]- | [Molecular Formula]
C17H17BrF3N7O2S | [MDL Number]
MFCD32062739 | [MOL File]
2361659-62-1.mol | [Molecular Weight]
520.33 |
| Chemical Properties | Back Directory | [Boiling point ]
671.0±65.0 °C(Predicted) | [density ]
1.74±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (20 mg/ml) | [form ]
solid | [pka]
10.07±0.10(Predicted) | [color ]
Beige | [Stability:]
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| Hazard Information | Back Directory | [Description]
GSK8612 (2361659-62-1) is a highly selective and potent (avg. pIC50 = 6.8 versus recombinant TBK1) inhibitor of Tank-binding Kinase-1 (TBK1) with higher affinity for unactivated TBK1.? It inhibited phosphorylation of IRF3 (pIC50 = 6.0), inhibited the release of IFNa from human PBMC’s (pIC50 = 6.1), and inhibited IFNb secretion from THP-1 cells (pIC50 = 5.8 dsDNA virus, 6.3 cGAMP stilmulated cells). | [Uses]
GSK 8612 is a highly selective TBK1 Inhibitor involved in regulating signaling pathways in immune responses. | [References]
Thomson et al. (2019), Discovery of a GSK8612, a Highly Selective and Potent TBK1 Inhibitor; ACS Med. Chem. Lett., 10 780 |
|
| Company Name: |
InvivoChem Gold
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|