| Identification | Back Directory | [Name]
NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE | [CAS]
220805-22-1 | [Synonyms]
ADMA
ADMA 2HCL
ADMA DIHYDROCHLORIDE
asym-Dimethylarginine
asym-Dimethylarginine, ADMA
NG,NG-DIMETHYLARGININE, DIHYDROCHLORIDE
NG,NG-dimethyl-L-Arginine (hydrochloride)
NG,NG-DIMETHYL-L-ARGININE DIHYDROCHLORIDE
NG,NG-Dimethylarginine Dihydrochloride Solution, 100ppm
N5-[(DIMETHYLAMINO)IMINOMETHYL]-L-ORNITHINE, DIHYDROCHLORIDE
(S)-2-aMino-5-(3,3-diMethylguanidino)pentanoic acid dihydrochloride | [Molecular Formula]
C8H20Cl2N4O2 | [MDL Number]
MFCD00270857 | [MOL File]
220805-22-1.mol | [Molecular Weight]
275.18 |
| Chemical Properties | Back Directory | [Appearance]
White Crystalline Solid | [Melting point ]
202-204OC | [storage temp. ]
Hygroscopic, -20°C Freezer, Under Inert Atmosphere | [solubility ]
DMSO (Slightly, Heated, Sonicated), Methanol (Slightly), Water (Slightly) | [form ]
White to off-white crystalline solid. | [color ]
White to Off-White | [Water Solubility ]
Soluble in water (100 mM) | [Stability:]
Store at 0-5°C; Moisture Sensitive; Hygroscopic | [CAS DataBase Reference]
220805-22-1 |
| Hazard Information | Back Directory | [Chemical Properties]
White Crystalline Solid | [Uses]
A potent inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells | [General Description]
NG,NG-Dimethylarginine dihydrochloride is a methylated arginine derivative, which is produced by the liver. It is linked to liver cirrhosis, alcoholic hepatitis and acute liver failure (ALF). | [Biological Activity]
ng,ng-dimethyl-l-arginine is an endogenous nitric oxide synthase inhibitor.nitric oxide (no) that is synthesised from l-arginine contributes to the regulation of blood pressure and to host defence. | [Biochem/physiol Actions]
Reversible inhibitor of nitric oxide synthetase in vivo and in vitro. | [in vitro]
ng,ng-dimethyl-l-arginine (adma) was found to be able to inhibit macrophage and vascular no synthase. when added to a cytosolic preparation of macrophage no synthase, adma could cause dose-dependent inhibition of no formation. in the presence of added arginine, adma could inhibited no synthesis and the inhibitory effects of adma were prevented by addition of l-arginine so that the rate of no synthesis did not significantly differ from control values [1]. | [in vivo]
animal study showed that the injection of 1-30 mg/kg adma into 3 anaesthetised guineapigs could cause dose-dependent increases in mean arterial blood pressure. moreover, during continuous infusion of adma, which caused plasma adma concentrations to rise approximately 9-fold, the systolic blood pressure was raised by nearly 15 % [1]. | [storage]
Store at -20°C | [References]
[1] vallance, p. ,leone, a.,calver, a., et al. accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. lancet 339, 572-575 (1992). |
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