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ChemicalBook--->CAS DataBase List--->159190-45-1

159190-45-1

159190-45-1 Structure

159190-45-1 Structure
IdentificationBack Directory
[Name]

L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
[CAS]

159190-45-1
[Synonyms]

L-NIL HCL
L-NIL DIHYDROCHLORIDE
L-N6-(1-Iminoethyl)lysine
OQIBCXRAFAHXMM-KLXURFKVSA-N
L-N6-(1-IMINOETHYL)-LYSINE 2HCL
L-N6-(1-IMINOETHYL)LYSINE, DIHCL
L-Lysine ω-acetamidine dihydrochloride
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
N6-(1-IMINOETHYL)-L-LYSINE DIHYDROCHLORIDE
L-Lysine, N6-(1-iMinoethyl)-, (Hydrochloride) (1:2)
[Molecular Formula]

C8H19Cl2N3O2
[MDL Number]

MFCD00270890
[MOL File]

159190-45-1.mol
[Molecular Weight]

260.16
Chemical PropertiesBack Directory
[storage temp. ]

-20°C
[solubility ]

DMF: 15 mg/mL; DMSO: 15 mg/mL; Ethanol: 1 mg/mL; PBS: 30 mg/mL; Water: 50 mg/ml
[form ]

White to off-white solid.
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
[Hazard Codes ]

Xi
[Risk Statements ]

36/37/38
[Safety Statements ]

37/39-26-36
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

L-NIL is a relatively selective inhibitor of iNOS. It exhibits IC50 values of 0.4-3.3 μM for iNOS as opposed to 8-38 and 17-92 μM for eNOS and nNOS, respectively. L-NIL effectively inhibits iNOS both in vitro and in vivo. L-NIL has been used to demonstrate a critical role for iNOS in the immune response to infection by the protozoan L. major.
[Uses]

L-N6-(1-Iminoethyl)lysine dihydrochloride has been used as an inducible nitric oxide synthase (iNOS) inhibitor:
  • to study its effects on leptin-induced modulation of fibronectin type III domain-containing five (FNDC5)/irisin in myocytes and fat cells of murine
  • to study its effects on leptin-induced inflammation in hepatocytes
  • to block the production of nitric oxide in mice bone marrow mesenchymal stromal cells (BMSCs)

[Definition]

ChEBI: N(6)-acetimidoyl-L-lysine dihydrochloride is a hydrochloride salt prepared from N(6)-acetimidoyl-L-lysine and two equivalents of hydrogen chloride. A selective inhibitor of inducible nitric oxide synthase. It has a role as an EC 1.14.13.39 (nitric oxide synthase) inhibitor. It contains a N(6)-acetimidoyl-L-lysinium(2+).
[Biochem/physiol Actions]

Selective inhibitor of inducible nitric oxide synthase (iNOS).
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