| Identification | More | [Name]
6-O-Benzylguanine | [CAS]
19916-73-5 | [Synonyms]
2-Amino-6-(benzyloxy)purine
2-amino-6-(phenylmethoxy)-9h-purine
6-BENZYLOXY-9H-PURIN-2-AMINE
6-BENZYLOXY GUANINE
6-O-BENZYLGUANINE
O6-BENZYLGUANINE
4 6-Benzyloxyguanine
6-BENZYLOXY GUANINE2-AMINO-6-BENZYLOXYPURINE
O(sup 6)benzylguanidine
2-Amino-6-(benzyloxy)-9H-purine
6-(Benzyloxy)-1H-purin-2-amine | [EINECS(EC#)]
1592732-453-0 | [Molecular Formula]
C12H11N5O | [MDL Number]
MFCD00269931 | [Molecular Weight]
241.25 | [MOL File]
19916-73-5.mol |
| Chemical Properties | Back Directory | [Appearance]
Light Yellow Solid | [Melting point ]
193(dec.) | [Boiling point ]
459.3±55.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
room temp | [solubility ]
methanol: 20 mg/mL
| [form ]
solid
| [pka]
7.47±0.20(Predicted) | [color ]
Off-White to Light Yellow | [Usage]
An irreversible inhibitor of the mammalian DNA repair protein, O6-alkylguanine-DNA alkyltransferase. Assists in the protection against carcinogenic and therapeutic alkylating agents. | [Detection Methods]
HPLC | [CAS DataBase Reference]
19916-73-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
Light Yellow Solid | [Uses]
An irreversible inhibitor of the mammalian DNA repair protein, O6-alkylguanine-DNA alkyltransferase. Assists in the protection against carcinogenic and therapeutic alkylating agents. | [Biochem/physiol Actions]
O6-Benzylguanine (O6BG) inhibits methylguanine methyltransferase (MGMT) by blocking the active site through benzyl group transfer. The use of O6BG with bis-chloroethylnitrosourea (BCNU) or carmustine is effective in treating solid tumors including lymphomas, melanomas and sarcoma. |
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