| Identification | More | [Name]
5-Hydroxyindole | [CAS]
1953-54-4 | [Synonyms]
1H-INDOL-5-OL
5-HYDROXYINDOLE
5-INDOLOL
INDOL-5-OL
TIMTEC-BB SBB004214
5-Hydroxy-1H-indole
Hydroxy-5 indole
hydroxy-5indole
Hydroxyindole,98%
5-hdroxyindole
5-HYDROXYINDOLE 99%
5-Hydroxyindole, 98+% | [EINECS(EC#)]
217-782-6 | [Molecular Formula]
C8H7NO | [MDL Number]
MFCD00005677 | [Molecular Weight]
133.15 | [MOL File]
1953-54-4.mol |
| Chemical Properties | Back Directory | [Appearance]
beige to brown crystalline needles or powder | [Melting point ]
106-108 °C(lit.) | [Boiling point ]
245.66°C (rough estimate) | [density ]
1.1475 (rough estimate) | [refractive index ]
1.5260 (estimate) | [storage temp. ]
0-6°C | [solubility ]
38g/l | [form ]
Crystalline Needles or Powder | [pka]
9.98±0.40(Predicted) | [color ]
beige
| [Sensitive ]
Light Sensitive | [Detection Methods]
HPLC | [BRN ]
112349 | [InChI]
InChI=1S/C8H7NO/c10-7-1-2-8-6(5-7)3-4-9-8/h1-5,9-10H | [InChIKey]
LMIQERWZRIFWNZ-UHFFFAOYSA-N | [SMILES]
N1C2=C(C=C(O)C=C2)C=C1 | [CAS DataBase Reference]
1953-54-4(CAS DataBase Reference) | [NIST Chemistry Reference]
Indol-5-ol(1953-54-4) | [Storage Precautions]
Store under nitrogen;Light sensitive |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [RTECS ]
NM2430000
| [HazardClass ]
IRRITANT, KEEP COLD | [HS Code ]
29339990 |
| Hazard Information | Back Directory | [Chemical Properties]
beige to brown crystalline needles or powder | [Uses]
• ;Reactant for preparation of (oxoimidazolidinyl/oxopyrimidinyl)benzenesulfonates as antitumor agents and tubulin inhibitors1• ;Reactant for preparation of anthranilic acids2• ;Reactant for preparation of indole compounds as dopamine D2 receptor antagonists3• ;Reactant for preparation of naphthalimide- or carbazole-containing human β-adrenoceptor ligands4• ;Reactant for preparation of melanins as nature-inspired radioprotectors5• ;Reactant for preparation of 5-vinyl-3-pyridinecarbonitriles as PKCθ inhibitors6 | [Uses]
5-Hydroxyindole is a hydroxylated indole used as a building block in the preparation of various pharmaceutical compounds such as indole based neurochemicals. 5-Hydroxyindole is a metabolite of Tryptop
han (T894800). 5-Hydroxyindole displayed weak inhibitory activity on human melanoma tyrosinase. 5-Hydroxyindole also showed inhibition of serotonin transport by blood platelets. | [Uses]
5-Hydroxyindole is a hydroxylated indole used as a building block in the preparation of various pharmaceutical compounds such as indole based neurochemicals. 5-Hydroxyindole is a metabolite of Tryptophan (T894800). 5-Hydroxyindole displayed weak inhibitory activity on human melanoma tyrosinase. 5-Hydroxyindole also showed inhibition of serotonin transport by blood platelets. | [Definition]
ChEBI: 5-hydroxyindole is a member of the class of hydroxyindoles that is 1H-indole in which the hydrogen at position 5 has been replaced by a hydroxy group. It has a role as a human metabolite. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 76, p. 5579, 1954 DOI: 10.1021/ja01651a001
The Journal of Organic Chemistry, 49, p. 4833, 1984 DOI: 10.1021/jo00199a017 |
|
|