| Identification | More | [Name]
5-Methoxyindole | [CAS]
1006-94-6 | [Synonyms]
5-METHOXY-1H-INDOLE
5-METHOXYINDOLE
AKOS JY2082918
RARECHEM AH BS 0117
TIMTEC-BB SBB004094
1H-Indol-5-yl methyl ether
5-methoxy-indol
Femedol
Indole, 5-methoxy-
Methoxy-5 indole
methoxy-5indole
Methoxyindole,99%
5-Methyoxy Indole
5-methyloxyl indole
5-Methoxylindole
Indol-5-yl methyl ether
5-METHOXYINDOLE REPANIDAL
Methoxyindole 99% indol-5-yl methyl ether
5-Methoxyindole ,98% | [EINECS(EC#)]
213-745-3 | [Molecular Formula]
C9H9NO | [MDL Number]
MFCD00005674 | [Molecular Weight]
147.17 | [MOL File]
1006-94-6.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light brownish crystalline powder | [Melting point ]
52-55 °C (lit.) | [Boiling point ]
176-178 °C/17 mmHg (lit.) | [density ]
1.1135 (rough estimate) | [refractive index ]
1.5310 (estimate) | [Fp ]
176-178°C/17mm | [storage temp. ]
2-8°C
| [solubility ]
Chloroform, Methanol | [form ]
Crystalline Powder | [pka]
16.70±0.30(Predicted) | [color ]
White to light brownish | [Water Solubility ]
insoluble | [Sensitive ]
Light Sensitive | [Detection Methods]
GC,NMR | [BRN ]
116722 | [InChIKey]
DWAQDRSOVMLGRQ-UHFFFAOYSA-N | [CAS DataBase Reference]
1006-94-6(CAS DataBase Reference) | [NIST Chemistry Reference]
1H-Indole, 5-methoxy-(1006-94-6) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S24/25:Avoid contact with skin and eyes .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [RTECS ]
NL9500000
| [F ]
8 | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT, KEEP COLD, LIGHT SENSITIVE | [HS Code ]
29339900 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
EthenaMine, 2-(5-Methoxy-2-nitrophenyl)-N,N-diMethyl-, (1E)--->1-Propanone, 1-(5-methoxy-1H-indol-1-yl)-2,2-dimethyl--->Benzene, 2-ethenyl-4-methoxy-1-nitro--->5-Methoxyindole-3-carboxaldehyde-->Phosphonium, [2-(1,1-dimethylethoxy)-2-oxoethyl]triphenyl-, inner salt-->1-BOC-5-METHOXYINDOLE-->5-methoxy-1-[(4-methylphenyl)sulfonyl]-1H-Indole-->5-Methoxy-2-nitrobenzaldehyde-->5-Methoxy-2,3-dihydroindoline-->TRIETHANOLAMINE HYDROCHLORIDE-->(5-METHOXY-2-NITRO-PHENYL)-ACETONITRILE-->5-Methoxy-3-indolecarboxylic acid-->5-METHOXYINDOLE-2-CARBOXYLIC ACID-->5-Bromoindole | [Preparation Products]
5-METHOXY-DL-TRYPTOPHAN-->5-METHOXYGRAMINE-->2-Amino-5-methoxybenzoic acid |
| Hazard Information | Back Directory | [Chemical Properties]
white to light brownish crystalline powder | [Uses]
5-Methoxyindole (cas# 1006-94-6) is a compound useful in organic synthesis. | [Definition]
ChEBI: 5-methoxyindole is a member of indoles. | [Preparation]
The synthesis of 5-methoxyindole from 5-methoxy-2-oxindole: Conversion of 5-methoxy-2-oxindole to 5-methoxyindole was accomplishedby the chlorination of 5-methoxy-2-oxindole with triphenylphosphine-carbontetrachloride in acetonitrile followed by the catalytic reduction of a chlorine atom in 66% total yield. | [Reactions]
5-methoxyindole was treated with sodium hydroxide and phenylsulfonyl chloride in the presence of a catalytic amount of tetrabutylammonium bromide to afford 1-(phenylsulfonyl)indole and 5-methoxy-1-(phenylsufonyl)indole in excellent yields of 100%. | [Synthesis Reference(s)]
Journal of Heterocyclic Chemistry, 26, p. 1405, 1989 DOI: 10.1002/jhet.5570260533
The Journal of Organic Chemistry, 58, p. 5558, 1993 DOI: 10.1021/jo00072a052
Tetrahedron Letters, 27, p. 837, 1986 DOI: 10.1016/S0040-4039(00)84114-3 | [Purification Methods]
Crystallise 5-methoxyindole from cyclohexane pet ether or pet ether/Et2O. [Saito & Kikugawa J Heterocycl Chem 16 1325 1979, Beilstein 21 III/IV 765, 21/3 V 18.] |
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