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ChemicalBook--->CAS DataBase List--->175865-60-8

175865-60-8

175865-60-8 Structure

175865-60-8 Structure
IdentificationMore
[Name]

Valganciclovir
[CAS]

175865-60-8
[Synonyms]

5-amino-3-[1-(hydroxymethyl)-2-(l-valyloxy)ethoxymethyl]-6,7-dihydro-3h-imidazo[4,5-d]pyrimidin-7-one
valganciclovir
Valgancyclovir
5-Amino-3-[1-(hydroxymethyl)-2-(L-valyloxy)ethoxymethyl]-6,7-dihydro-3H-imidazo[4,5-d]pyrimidin-7-one
[EINECS(EC#)]

1312995-182-4
[Molecular Formula]

C14H22N6O5
[MDL Number]

MFCD23701445
[Molecular Weight]

354.362
[MOL File]

175865-60-8.mol
Chemical PropertiesBack Directory
[density ]

1.59±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[pka]

9.32±0.20(Predicted)
[BCS Class]

3
[CAS DataBase Reference]

175865-60-8(CAS DataBase Reference)
Safety DataBack Directory
[Hazardous Substances Data]

175865-60-8(Hazardous Substances Data)
Hazard InformationBack Directory
[Uses]

Antiviral.
[Definition]

ChEBI: The L-valinyl ester of ganciclovir, into which it is rapidly converted by intestinal and hepatic esterases. It is a synthetic analogue of 2'-deoxyguanosine.
[Indications]

Valganciclovir (Valcyte) is the L-valyl ester prodrug of ganciclovir.
[Brand name]

Valcyte (Roche).
[Clinical Use]

Oral valganciclovir is comparable to intravenous ganciclovir for the treatment and suppression of CMV retinitis in AIDS patients.
[Drug interactions]

Potentially hazardous interactions with other drugs
Antibacterials: increased risk of convulsions with imipenem-cilastatin.
Antivirals: possibly increased didanosine concentration; profound myelosuppression with zidovudine - avoid if possible.
Mycophenolate: possibly increased concentrations of both mycophenolic acid and ganciclovir.
Increased risk of myelosuppression with other myelosuppressive drugs.
[Metabolism]

Valganciclovir is well absorbed from the gastrointestinal tract and rapidly and extensively metabolised in the intestinal wall and liver to ganciclovir. Valganciclovir is eliminated in the urine as unchanged ganciclovir, mainly by glomerular filtration and also active tubular secretion.
[storage]

Store at -20°C
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