| Identification | More | [Name]
Naltrexone hydrochloride | [CAS]
16676-29-2 | [Synonyms]
(5A)-17-(CYCLOPROPYLMETHYL)-4,5-EPOXY-3,14-DIHYDROMORPHINAN-6-ONE HYDROCHLORIDE
(5alpha)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride
NALTREXONE HYDROCHLORIDE
N-CYCLOPROPYLMETHYL-14-HYDROXYDI-HYDROMORPHINONE HYDROCHLORIDE
(5-alpha)-id
17-(cyclopropylmethyl)-4,5-alpha-epoxy-3,14-dihydroxy-morphinan-6-onehydroch
17-(cyclopropylmethyl)-4,5-alpha-epoxy-3,14-dihydroxy-morphinan-6-onhydr
17-(cyclopropylmethyl)-4,5-alpha-oxy-3,14-dihydoxy-morphinan-6-onhydrochlo
17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-morphinan-6-onhydrochlor
en1639a
n-cyclopropylmethyl-noroxymorphonehydrochloride
nih8503
Antaxone, Celupan
Nalorex
ReVia
NALTREXONEHYDROCHLORIDE,USP | [EINECS(EC#)]
240-723-0 | [Molecular Formula]
C20H24ClNO4 | [MDL Number]
MFCD00069324 | [Molecular Weight]
377.86 | [MOL File]
16676-29-2.mol |
| Chemical Properties | Back Directory | [Appearance]
White Crystalline Powder | [Melting point ]
274-2760C | [storage temp. ]
2-8°C
| [solubility ]
H2O: 50 mg/mL, clear, colorless
| [form ]
neat | [color ]
White to Off-White | [Water Solubility ]
Soluble in water at 50mg/ml. | [Sensitive ]
Light Sensitive | [Usage]
Nonselective opioid receptor antagonist; congener of naloxone | [Merck ]
13,6389 | [BRN ]
3580333 | [CAS DataBase Reference]
16676-29-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S22:Do not breathe dust .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
QD2160000
| [F ]
8-10 | [HS Code ]
2932.99.7000 | [Toxicity]
guinea pig,LD50,oral,1490mg/kg (1490mg/kg),Medicamentos de Actualidad. Vol. 21, Pg. 264, 1985. |
| Hazard Information | Back Directory | [Description]
Naltrexone hydrochloride is a potent, long-acting, orally-effective narcotic
antagonist useful in the management of narcotic addiction. | [Chemical Properties]
White Crystalline Powder | [Originator]
Endo (USA) | [Uses]
Analgesic;Opioid antagonist | [Uses]
Narcotic antagonist, In treatment of?alcoholism | [Uses]
Nonselective opioid receptor antagonist; congener of naloxone | [Uses]
sulfonamide, carbonic anhydrase inhibitor, anti-glaucoma agent | [Definition]
ChEBI: Naltrexone hydrochloride is a hydrochloride obtained by reaction of oxycodone with one molar equivalent of hydrochloric acid. it is a mu-opioid receptor antagonist that is used to treat alcohol dependence. It has a role as a mu-opioid receptor antagonist, an antidote to opioid poisoning and a central nervous system depressant. It contains a naltrexone(1+). | [Brand name]
TREXAN | [Biological Activity]
Opioid antagonist. | [Biochem/physiol Actions]
Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone. | [Clinical Use]
Opioid antagonist:
Adjunctive prophylactic treatment in patient’s
previously opioid dependant
Treatment of alcohol dependence | [Drug interactions]
Potentially hazardous interactions with other drugs
Opioids: Avoid concomitant use. | [Metabolism]
Naltrexone is well absorbed from the gastrointestinal
tract but is subject to considerable first-pass metabolism
and may undergo enterohepatic recycling. It is extensively
metabolised in the liver and the major metabolite,
6-β-naltrexol, may also possess weak opioid antagonist
activity.
It is excreted mainly in the urine, <5% is excreted in the
faeces.
The renal clearance for naltrexone ranges from 30-127
mL/min and suggests that renal elimination is primarily
by glomerular filtration | [storage]
Room temperature | [Purification Methods]
This narcotic antagonist has been purified by recrystallisation from MeOH and dried in air. The free base has m 168-170o after recrystallisation from Me2CO. [Cone et al. J Pharm Sci 64 618 1975, Gold et al. Med Res Rev 2 211 1982.] |
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