| Identification | More | [Name]
Ferrous fumarate | [CAS]
141-01-5 | [Synonyms]
FERROUS FUMARATE
FERROUS FUMERATE
IRON(+2)FUMARATE
IRON FUMARATE
IRON(II) FUMARATE
2-Butenedioicacid(E)-,iron(2+)salt(1:1)
cpiron
erco-fer
ercoferro
feostat
feroton
ferrofume
ferronat
ferrone
ferrotemp
Ferroustrans-butenedioicacid
fersamal
Fersanmal
firon
fumafer | [EINECS(EC#)]
205-447-7 | [Molecular Formula]
C4H2FeO4 | [MDL Number]
MFCD00058315 | [Molecular Weight]
169.9 | [MOL File]
141-01-5.mol |
| Chemical Properties | Back Directory | [Definition]
Anhydrous salt of a combination of ferrous iron and
fumaric acid, stable, odorless, substantially tasteless. Reddish-brown, anhydrous powder, contains
33% iron by weight, does not melt at temperatures
up to 280C, insoluble in alcohol, very slightly solubl | [Appearance]
brown to reddish-brown powder | [Melting point ]
>280°C | [density ]
2.435 | [vapor pressure ]
0Pa at 25℃ | [storage temp. ]
Refrigerator | [solubility ]
Slightly soluble in water, very slightly soluble in ethanol (96 per cent). | [form ]
solid | [color ]
Dark Red to Dark Brown | [Stability:]
Stability | [Water Solubility ]
Soluble in water (0.14 g/100 ml at 25°C). | [Merck ]
14,4046 | [Exposure limits]
ACGIH: TWA 1 mg/m3
NIOSH: TWA 1 mg/m3 | [InChIKey]
PMVSDNDAUGGCCE-TYYBGVCCSA-L | [LogP]
0.62 | [Uses]
Ferrous Fumarate is a reddish orange to red-brown powder that is a
source of iron. it has high bioavailability and can be used in foods
where the red color can be masked. it contains approximately 33%
iron. it is used as a dietary supplement in breakfast cereals, poultry
stuffing, enriched flour, and instant drinks. | [CAS DataBase Reference]
141-01-5(CAS DataBase Reference) | [EPA Substance Registry System]
141-01-5(EPA Substance) |
| Safety Data | Back Directory | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
2 | [RTECS ]
LT1950000 | [TSCA ]
Yes | [HS Code ]
29171900 | [Safety Profile]
Poison by
intraperitoneal route. Moderately toxic by
ingestion and subcutaneous routes. Human
systemic effects by ingestion: dyspnea,
nausea or vomiting, somnolence. When
heated to decomposition it emits acrid
smoke and irritating fumes. See also
FUMRIC ACID. | [Toxicity]
LD50 in mice, rats (mg Fe/kg): 630, 580 orally (Berenbaum) |
| Hazard Information | Back Directory | [Description]
Ferrous fumarate is the ferrous salt form of fumarate. One of its most important applications is being used as iron supplements for the treatment of iron deficiency and anemia. It has been demonstrated that application of ferrous sulfate drops or a single daily dose of microencapsulated ferrous fumarate sprinkles plus ascorbic acid both result in successful treatment of anemia without remarkable side effects. However, recent studies have also shown that compared to other iron supplements, ferrous fumarate has a highest rate of inducing adverse reactions such as erosive mucosal injury in the gastrointestinal tract as well as nausea, vomiting and epigastric discomfort.
| [Chemical Properties]
§184.1307d(a) Ferrous fumarate (iron(II)fumarate, C4H2Fe04) is an odorless, reddish-orange to reddish-brown powder. It may contain soft lumps that produce a yellow streak when crushed. It is prepared by admixing hot solutions of ferrous sulfate and sodium fumarate.
| [Chemical Properties]
brown to reddish-brown powder | [Originator]
Toleron,Mallinckrodt Inc.,US,1957 | [Manufacturing Process]
Sodium carbonate (53.5 pounds of Na2CO3-H2O) was dissolved in water (40 to
45 gallons) and fumaric acid (50 pounds) was added slowly. During the
addition the solution was stirred and heated. The resulting solution of sodium
fumarate, having a pH of 6.8, was added slowly with mixing to a solution of
ferrous sulfate (118 pounds FeSO4-7H2O in 33 gallons of water) having a pH
of 3.3, both solutions being maintained at or near boiling temperature during
the mixing. The resulting slurry of reddish-brown anhydrous ferrous fumarate
was filtered and washed in a centrifuge and dried in a tray drier (15 hours at
110°C). Yield: 63 pounds, 86% of theory. Calculated for FeC4H2O4: Fe,
32.9%. Found: Fe, 32.6%. Only 0.2% of ferric iron (Fe+++) was found. | [Therapeutic Function]
Hematinic | [General Description]
Ferrous fumarate is a commonly used inexpensive substitute for other forms of iron, that is employed as a food iron fortificant.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. | [Flammability and Explosibility]
Notclassified | [Clinical Use]
Iron deficiency anaemia | [Drug interactions]
Potentially hazardous interactions with other drugs
Antibacterials: reduced absorption of 4-quinolones
and tetracyclines.
Dimercaprol: avoid concomitant use.
Mycophenolate: may significantly reduce absorption
of mycophenolate. | [Metabolism]
Molecular weight (daltons) 169.9
% Protein binding -
% Excreted unchanged in urine -
Volume of distribution (L/kg) -
Half-life - normal/ESRF (hrs) - | [storage]
Store at RT | [References]
Zlotkin, Stanley, et al. "Treatment of anemia with microencapsulated ferrous fumarate plus ascorbic acid supplied as sprinkles to complementary (weaning) foods." The American journal of clinical nutrition 74.6 (2001): 791-795.Cancelo-Hidalgo, María Jesús, et al. "Tolerability of different oral iron supplements: a systematic review." Current medical research and opinion 29.4 (2013): 291-303. |
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