| Identification | Back Directory | [Name]
AHU-377 (heMicalciuM salt) | [CAS]
1369773-39-6 | [Synonyms]
(alphar
LCZ696-1
Sacubitril Calcium
AHU377 Calcium Salt
AHU-377 Hemicalcium
LCZ696 Impurity 534-06
Sacubitril calcium salt
AHU-377 (heMicalciuM salt)
Sacubitril Hemicalcium salt
AHU-377 hemicalcium salt (2:1)
LCZ696(valsartan + sacubitril) impurity 1
LCZ696 intermediates，AHU-377 (heMicalciuM salt)
gammas)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1
1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1)
Calcium4-(((2R,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate
Ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoate hemicalcium salt
(αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoicacid4-ethylestercalciumsal
Calciumbis(4-{[(1S,3R)-1-([1,1'-biphenyl]-4-ylmethyl)-4-ethoxy-3-methyl-4-oxobutyl] amino} -4-oxobutanoate)
(2S,4R)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester,calcium salt(2:1)
(αR,γS)-γ-[(3-Carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt
monocalciummono(4-(((2R,4S)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy- 4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate)
(alphaR, gammaS) -gamma-[(3- carbonyl, -1-, oxo propyl), amino]-alpha-, biphenyl, -4-, ethyl valerate, calcium salt
[1,1'-Biphenyl]-4-pentanoic acid, γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-, 4-ethyl ester, calcium salt (2:1), (αR,γS)-
(alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1)
(alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1) (AHU-377 hemicalcium salt) | [EINECS(EC#)]
935-847-3 | [Molecular Formula]
C48H56CaN2O10 | [MDL Number]
MFCD28137893 | [MOL File]
1369773-39-6.mol | [Molecular Weight]
861.044 |
| Chemical Properties | Back Directory | [Melting point ]
>140°C (dec.) | [density ]
1.24g/cm3 at 20℃ | [vapor pressure ]
0.001Pa at 20℃ | [storage temp. ]
-20°C | [solubility ]
DMSO (Slightly, Heated), Methanol (Slightly) | [form ]
powder | [color ]
white to beige | [LogP]
-0.66-2.9 at 20℃ and pH2-7 |
| Hazard Information | Back Directory | [Uses]
Sacubitril is an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure. | [Biochem/physiol Actions]
Sacubitril (AHU377) is a prodrug inhibitor of the membrane metallo-endopeptidase neprilysin. Sacubitril forms half of the heart failure combination drug LCZ696, along with the angiotensin-receptor blocker Valsartan. Sacubitril (AHU377) is cojnverted by esterases into the active inhibitor LBQ657, which prevents neprilysin′s degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides. The AHU377 valsartan combination drug LCZ696 showed a reduction in the risk of cardiovascular death of 20% compared to the standard ACE inhibitor enalapril, and also a 21% drop in the risk of hospitalization. | [storage]
Store at -20°C |
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