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ChemicalBook--->CAS DataBase List--->133053-19-7

133053-19-7

133053-19-7 Structure

133053-19-7 Structure
IdentificationBack Directory
[Name]

GO 6983
[CAS]

133053-19-7
[Synonyms]

CS-674
gǒ 6983
GOE 6983
Gδ 6983
Go6983(96 %)
GO6983 GO-6983
GO 6983 USP/EP/BP
G 6983 - GO 6983 | Goe 6983
GOE 6983;GO6983 GO-6983;GO 6983
G 6983 - CAS 133053-19-7 - Calbiochem
3-[1-(3-Dimethylamino-propyl)-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 3-[1-[3-(dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-
[Molecular Formula]

C26H26N4O3
[MDL Number]

MFCD04040031
[MOL File]

133053-19-7.mol
[Molecular Weight]

442.51
Chemical PropertiesBack Directory
[Boiling point ]

709.0±60.0 °C(Predicted)
[density ]

1.31±0.1 g/cm3(Predicted)
[storage temp. ]

-20°C
[solubility ]

DMSO: 20 mg/mL, clear, red
[form ]

powder
[pka]

8.02±0.60(Predicted)
[color ]

red
[Stability:]

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

36/37/38
[Safety Statements ]

26-36
[WGK Germany ]

3
[HS Code ]

2933998090
Hazard InformationBack Directory
[Description]

Go-6983 (133053-19-7) potent and pan-specific, ATP-competitive protein kinase C inhibitor. PKC isotype IC50s= 7, 7, 6, 10 and 60 nM for PKC α, β, γ, δ, ζ respectively.1 Suppresses stress induced HSP27 disassociation.2 Maintains rat embryonic stem cell pluripotency.3 Attenuates myocardial ischemia/reperfusion injury.4
[Uses]

Go 6983, is a protein kinase C (PKC) inhibitor.Potent PKC Inhibitor
[Definition]

ChEBI: 3-[1-[3-(dimethylamino)propyl]-5-methoxy-3-indolyl]-4-(1H-indol-3-yl)pyrrole-2,5-dione is a member of indoles and a member of maleimides.
[Biological Activity]

Broad spectrum protein kinase C (PKC) inhibitor (IC 50 values are 7, 7, 6, 10, 60 and 20000 nM for PKC α , PKC β , PKC γ , PKC δ , PKC ζ and PKC μ respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury.
[Biochem/physiol Actions]

Protein kinase C (PKC) inhibitor that selectively inhibits several PKC isozymes (IC50 = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ), but does not inhibit PKCμ (IC50 = 20 mM).
[storage]

-20°C
[References]

1) Gschwendt et al. (1996), Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase C isoenzymes; FEBS Lett., 392 77 2) Kato et al. (2001), Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27; Cell Stress Chaperones, 6 16 3) Rajendran et al. (2013), Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency; J. Biol. Chem., 288 24351 4) Young et al. (2005), Go 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury; Cardiovasc, Drug Rev., 23 255
Spectrum DetailBack Directory
[Spectrum Detail]

GO 6983(133053-19-7)1HNMR
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