| Identification | More | [Name]
Chloramine-T | [CAS]
127-65-1 | [Synonyms]
CHLORAMINE T
CHLORAMINE T POLYMER BOUND
CHLORAMINE T SODIUM
CHLORASEPTINE
CHLORAZONE
EUCLORINA
GANSIL
GYNECHLORINA
IODO-BEADS(R)
MIANINE
MONOCHLORAMINE REAGENT
N-CHLORO-4-METHYL-BENZENESULFONAMIDE SODIUM
N-CHLORO-4-TOLUENESULFONAMIDE, SODIUM SALT
N-CHLORO-P-TOLUENESULFONAMIDE SODIUM SALT
N-CHLORO-P-TOLUENESULPHONAMIDE, SODIUM SALT
P-TOLUENESULFONCHLORAMIDE SODIUM SALT
SODIUM-P-TOLUENESULFONCHLORAMIDE
Tosylchloramide sodium
(n-chloro-p-toluenesulfonamido)sodium
acti-chlore | [EINECS(EC#)]
204-854-7 | [Molecular Formula]
C7H7ClNNaO2S | [MDL Number]
MFCD00000522 | [Molecular Weight]
227.64 | [MOL File]
127-65-1.mol |
| Chemical Properties | Back Directory | [Appearance]
white or yellow powder with a chlorine-like odour | [Melting point ]
167-170 °C(lit.)
| [density ]
1.401[at 20℃] | [vapor pressure ]
0Pa at 25℃ | [storage temp. ]
2-8°C
| [solubility ]
H2O: >100 mg/mL
| [form ]
Solid | [pka]
0.39[at 20 ℃] | [color ]
White to off-white | [Stability:]
Stable. Incompatible with strong oxidizing agents. May decompose violently if heated above 130 C. May decompose on exposure to air. | [Water Solubility ]
150g/L at 25℃ | [InChI]
InChI=1S/C7H7ClNO2S.Na/c1-6-2-4-7(5-3-6)12(10,11)9-8;/h2-5H,1H3;/q-1;+1 | [InChIKey]
VDQQXEISLMTGAB-UHFFFAOYSA-N | [SMILES]
S(=O)(=O)(N(Cl)[Na])C1C=CC(C)=CC=1 | [LogP]
-1.3 at 20℃ | [CAS DataBase Reference]
127-65-1(CAS DataBase Reference) | [EPA Substance Registry System]
127-65-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
C,Xn | [Risk Statements ]
R22:Harmful if swallowed.
R31:Contact with acids liberates toxic gas.
R34:Causes burns.
R42:May cause sensitization by inhalation. | [Safety Statements ]
S22:Do not breathe dust .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S7:Keep container tightly closed .
S1/2:Keep locked up and out of the reach of children . | [RIDADR ]
UN 3263 8/PG 3
| [WGK Germany ]
2
| [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29242990 | [Safety Profile]
Poison by parenteral and intravenous routes. Human mutagenic data reported. When heated to
decomposition it emits toxic fumes of Cl-,
SOx, Na2O, and NOx. See also
SULFONATES and CHLORIDES. | [Hazardous Substances Data]
127-65-1(Hazardous Substances Data) |
| Hazard Information | Back Directory | [Description]
The sodium salt of p-toluenesulfochloramide, commonly known as chloramine-T, exerts strong oxidizing action in both acidic and alkaline media and thus has been widely used for the oxidimetric determination of a large number of inorganic and organic substances.
Oxidation of some aldehydes by chloramine-T has been reported to occur quantitatively in an alkaline solution, giving the corresponding acid as the end product. Both direct and indirect methods have been carried out to estimate aldehydes by chloramine-T. Chloramine-T (CAT) is also commonly used in radiolabeling bioactive molecules by halogenation. CAT is used to release radioactive elemental iodine by oxidation of its salts. Unfortunately, CAT is a strong oxidizing agent and can cause significant damage to peptides and proteins. This may lower the yield of the iodination reaction and may produce undesirable side products[1-2].
| [Chemical Properties]
white or yellow powder with a chlorine-like odour | [Uses]
antiseptic, disinfestant, antiproliferative | [Uses]
sterilizer, antiseptic, disinfectant, and chemical reagent in the medical and pharmaceutical fields. | [Uses]
This disinfectant is for external use only, it can exterminate bacteria, viruses, fungi, spore. The action principle is that chlorine can sterilize slowly and lastingly, and also can dissolve necrotic tissue, chlorine come from hypochlorous acid which is produced by Chloramine-T solution. Apply to disinfect drinking water container,food,all kind of tableware, fruits and vegetables,and cleaning wound, mucous membrane. | [Definition]
ChEBI: An organic sodium salt derivative of toluene-4-sulfonamide with a chloro substituent in place of an amino hydrogen. | [Flammability and Explosibility]
Notclassified | [Synthesis]
Chloramine-T is prepared
in 75 – 95 % yield by passing chlorine into a
sodium hydroxide solution of p-toluenesulfonamide. It is a strong electrolyte in acid
solution and a good oxidizing agent in base. It is
fairly soluble in water, and practically insoluble
in benzene, chloroform, and ether. The compound reacts readily with mustard gas to yield
a harmless crystalline sulfimide; chloramine-T
derivatives are being studied as protective agents
against poison gas.
 | [References]
[1] M. C. Agrawal, S. P. Mushran. "Mechanism of Oxidation of some Aliphatic Aldehydes by Chloramine-T." Zeitschrift für Naturforschung B 20 1 (1972): 401–404.
[2] B M Tashtoush. "Chloramine-T in radiolabeling techniques. IV. Penta-O-acetyl-N-chloro-N-methylglucamine as an oxidizing agent in radiolabelling techniques." Analytical biochemistry 288 1 (2001): 16–21. |
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