| Identification | Back Directory | [Name]
UNC0321 | [CAS]
1238673-32-9 | [Synonyms]
UNC0321
UNC0321(UNC-0321)
UNC 0321; UNC-0321; UNC0321; UNC-0321
7-(2-(2-(diMethylaMino)ethoxy)ethoxy)-6-Methoxy-2-(4-Methyl-1,4-diazepan-1-yl)-N-(1-Methylpiperidin-4-yl)quinazolin-4-aMine
7-[2-[2-(Dimethylamino)ethoxy]ethoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine
4-Quinazolinamine, 7-[2-[2-(dimethylamino)ethoxy]ethoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)- | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C27H45N7O3 | [MDL Number]
MFCD18251565 | [MOL File]
1238673-32-9.mol | [Molecular Weight]
515.69 |
| Chemical Properties | Back Directory | [Boiling point ]
664.7±65.0 °C(Predicted) | [density ]
1.150±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 31 mg/mL (60.11 mM) | [form ]
Powder | [pka]
9.34±0.70(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Definition]
ChEBI: 7-[2-[2-(dimethylamino)ethoxy]ethoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methyl-4-piperidinyl)-4-quinazolinamine is a member of quinazolines. | [Biological Activity]
UNC0321 is a potent and selective histone methyltransferase G9a inhibitor with Ki of 63 pM and IC50 of 6-9 nM.It also inhibits GLP with IC50 values of 15-23 nM.UNC0321 is inactive against SET7/9, SET8/PreSET7, PRMT3 and JMJD2E. | [in vitro]
In G9a ECSD and CLOT assays, the IC 50 values of 9 nM and 6 nM for UNC0321 (Compound 29), respectively. In GLP ECSD and CLOT assays, the IC 50 values of 15 nM and 23 nM for UNC0321, respectively.
UNC0321 (Compound 3) reduces H3K9me2 levels in MDA-MB-231 cells with an IC50 of 11 μM. | [target]
| G9a 63 pM (Ki) | G9a 6-9 nM (IC 50 ) | GLP 15-23 nM (IC 50 ) | |
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