天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook--->CAS DataBase List--->1010732-14-5

1010732-14-5

1010732-14-5 Structure

1010732-14-5 Structure
IdentificationBack Directory
[Name]

Maritoclax
[CAS]

1010732-14-5
[Synonyms]

Maritoclax
Marinopyrrole A
Methanone, 1,1'-[(1R)-4,4',5,5'-tetrachloro[1,3'-bi-1H-pyrrole]-2,2'-diyl]bis[1-(2-hydroxyphenyl)-
[Molecular Formula]

C22H12Cl4N2O4
[MOL File]

1010732-14-5.mol
[Molecular Weight]

510.15
Hazard InformationBack Directory
[Description]

Maritoclax, also known as Marinopyrrole A , is a small molecule Mcl-1 inhibitor, which induces Mcl-1 proteasomal degradation without transcriptional downregulation. Maritoclax killed AML cell lines and primary cells with elevated Mcl-1 levels through selective Mcl-1 downregulation, and synergized with ABT-737 to overcome Mcl-1-mediated ABT-737 resistance. Maritoclax was more effective than daunorubicin at inducing leukemic cell death when co-cultured with HS-5 bone marrow stroma cells, while being less toxic than daunorubicin against HS-5 stroma cells, primary mouse bone marrow cells, and hematopoietic progenitor cells. Moreover, maritoclax administration at 20 mg/kg/d intraperitoneally caused significant U937 tumor shrinkage, as well as 36% tumors remission rate in athymic nude mice, without apparent toxicity to healthy tissue or circulating blood cells. In summary, our studies suggest that maritoclax belongs to a novel class of Mcl-1 inhibitors that has the potential to be developed for the treatment of AML. ( Cancer Biol Ther. 2014 Aug;15(8):1077-86. )
[Definition]

ChEBI: (-)-marinopyrrole A is a member of the class of pyrroles that is 1'H-1,3'-bipyrrole substituted by four chloro groups at positions 4, 4', 5 and 5' and two 2-hydroxybenzoyl moieties at positions 2 and 2'. It is isolated from Streptomyces sp.CNQ-418 and exhibits cytotoxic and antibacterial activities. It has a role as an antimicrobial agent, an antibacterial agent, an antineoplastic agent, a marine metabolite and a bacterial metabolite. It is a member of pyrroles, an organochlorine compound, a member of phenols and an aromatic ketone.
1010732-14-5 suppliers list
Company Name: Shanghai Zeye Biotechnology Co., Ltd.  
Tel: 021-61998551 13122364865
Website: www.approvedhomemanagement.com/showsupplierproductslist729391/0.htm
Company Name: Jiangxi Jianglan Pure Biological Reagent Co., Ltd.  
Tel: 021-54720761
Website: www.approvedhomemanagement.com/ShowSupplierProductsList1964511/0.htm
Company Name: Shanghai Wowu Biological Technology Co., Ltd.  
Tel: 021-57886085 17317861055
Website: www.shhebio.com
Company Name: Shanghai Hao Biological Technology Co., Ltd.  
Tel: 021-58116080 18019263206
Website: www.xiyuan-bio.com
Company Name: Shanghai Hao Biological Technology Co., Ltd.  
Tel: 021-80370006 13585899102
Website: www.xlswkj.com
Company Name: Shanghai Machine Pure Industrial Co., Ltd.  
Tel: 021-54720761 13524933993
Website: www.gelatins.com.cn
Company Name: Guangzhou Weijia Technology Co., Ltd.  
Tel: 020-84224925 18300190102
Website: www.whiga.com.cn
Company Name: Shanghai Yijie Biological Technology Co., Ltd.  
Tel: 021-24209075
Website: www.approvedhomemanagement.com/ShowSupplierProductsList732140/0.htm
Company Name: Shanghai Yuda Industrial Co., Ltd.  
Tel: 021-64133189 13788995069
Website: www.runwelltac.com
Company Name: Shanghai Weiwei Biological Technology Co., Ltd.  
Tel: 021-55669583 18616258598
Website: www.apexbio.cn
Tags:1010732-14-5 Related Product Information
1609402-14-3 1238673-32-9 1628208-23-0 1168091-68-6 310456-65-6 1782235-14-6 847499-27-8 1627709-94-7 1316215-12-9 1594092-37-1 1613724-42-7 905281-76-7 160003-66-7 1310340-58-9