| Identification | More | [Name]
Propionic anhydride | [CAS]
123-62-6 | [Synonyms]
PROPANOIC ANHYDRIDE
PROPIONIC ANHYDRIDE
Anhydrid kyseliny propionove
anhydridkyselinypropionove
C2H5C(O)OC(O)C2H5
Methylacetic anhydride
methylaceticanhydride
Propanoicacid,anhydride
Propinoicanhydride
propionic
Propionic acid anhydride
propionicacidanhydride
Propionyl oxide
propionyloxide
Propionic Anhydried
Propanic Anhydride
PROPIONIC ANHYDRIDE, 99+%
PropionicAnhydrideForSynthesis
Propionic anhydride 97%
PROPIONSAEUREANHYDRID | [EINECS(EC#)]
204-638-2 | [Molecular Formula]
C6H10O3 | [MDL Number]
MFCD00009303 | [Molecular Weight]
130.14 | [MOL File]
123-62-6.mol |
| Chemical Properties | Back Directory | [Appearance]
Propionic anhydride is a colorless liquid.
Strong, pungent, unpleasant odor. | [Melting point ]
-42 °C | [Boiling point ]
167 °C(lit.)
| [density ]
1.015 g/mL at 25 °C(lit.)
| [vapor density ]
4.5 (vs air)
| [vapor pressure ]
10 mm Hg ( 57.7 °C)
| [refractive index ]
n20/D 1.404(lit.)
| [Fp ]
165 °F
| [storage temp. ]
Store below +30°C. | [solubility ]
H2O: decomposes (when in contact with water) | [form ]
clear liquid | [color ]
Colorless to Almost colorless | [Odor]
like acetaldehyde | [PH]
2.5 (100g/l, H2O, 20℃)(calculated on the free acid) | [Stability:]
Stable. Combustible. Incompatible with strong oxidizing agents, water, moisture, most common metals, active halogen compounds, ammonia, amines. | [explosive limit]
1.3-9.5%(V) | [Water Solubility ]
hydrolyses | [Sensitive ]
Moisture Sensitive | [Merck ]
14,7826 | [BRN ]
507066 | [Dielectric constant]
18.0（16℃） | [LogP]
0.33 at 20℃ | [CAS DataBase Reference]
123-62-6(CAS DataBase Reference) | [NIST Chemistry Reference]
Propanoic acid, anhydride(123-62-6) | [EPA Substance Registry System]
123-62-6(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2496 8/PG 3
| [WGK Germany ]
1
| [RTECS ]
UF9100000
| [Autoignition Temperature]
545 °F | [Hazard Note ]
Corrosive/Moisture Sensitive | [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29159000 | [Safety Profile]
Moderately toxic by
ingestion. Mildly toxic by skin contact. A
corrosive irritant to skin, eyes, and mucous
membranes. Combustible when exposed to
heat or flame; can react with oxidizing
materials. To fight fire, use CO2, dry
chemical. When heated to decomposition it
emits acrid smoke and irritating fumes. Used
as an esterifyng agent and dehydrating
agent. See also ANHYDRIDES. | [Hazardous Substances Data]
123-62-6(Hazardous Substances Data) | [Toxicity]
LD50 orally in rats: 2.36 g/kg (Smyth) |
| Hazard Information | Back Directory | [General Description]
Colorless liquid with a pungent odor. Flash point 165°F. Density 8.4 lb /gal. Corrosive to metals and tissue. | [Reactivity Profile]
PROPIONIC ANHYDRIDE(123-62-6) reacts exothermically with water. The reactions are sometimes slow, but can become violent when local heating accelerates their rate. Acids accelerate the reaction with water. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases. | [Air & Water Reactions]
Decomposes exothermically in water to form a corrosive solution of propionic acid [Merck, 11th ed. 1989]. | [Hazard]
Strong irritant to tissue.
| [Health Hazard]
Inhalation causes irritation of eyes and respiratory tract. Contact with liquid causes burns of eyes and skin. Ingestion causes burns of mouth and stomach. | [Potential Exposure]
Used in the manufacture of perfumes,
flavorings, alkyd resins; dyestuffs, pharmaceuticals; as an
esterifying agent for fats, oils, and cellulose; dehydrating
medium for nitrations and sulfonations. | [Fire Hazard]
Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions, includ-
ing resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medi-
cal attention. If victim is conscious, administer water, or
milk. Do not induce vomiting. Medical observation is
recommended for 24?48 hours after breathing overexpo-
sure, as pulmonary edema may be delayed. As first aid for
pulmonary edema, a doctor or authorized paramedic may
consider administering a drug or other inhalation therapy. | [Shipping]
UN2496 Propionic anhydride, Hazard class: 8;
Labels: 8-Corrosive material. | [Incompatibilities]
Vapors may form explosive mixture with
air. Incompatible with oxidizers (chlorates, nitrates, perox-
ides, permanganates, perchlorates, chlorine, bromine, fluo-
rine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids,
oxoacids, epoxides, reducing agents; alcohols and metals.
Contact with water forms heat 1 flammable propionic acid.
Compounds of the carboxyl group react with all bases, both
inorganic and organic (i.e., amines) releasing substantial
heat, water and a salt that may be harmful. Incompatible
with arsenic compounds (releases hydrogen cyanide gas),
diazo compounds, dithiocarbamates, isocyanates, mercap-
tans, nitrides, and sulfides (releasing heat, toxic and possibly
flammable gases), thiosulfates and dithionites (releasing
hydrogen sulfate and oxides of sulfur). | [Description]
Propanoic anhydride is an organic compound with the formula (CH3CH2CO)2O. This simple acid anhydride is a colourless liquid. It is a widely used reagent in organic synthesis. | [Chemical Properties]
colourless liquid with an unpleasant odour | [Chemical Properties]
Propionic anhydride is a colorless liquid.
Strong, pungent, unpleasant odor. | [Waste Disposal]
Use a licensed professional
waste disposal service to dispose of this material. Dissolve
or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner
and scrubber. All federal, state, and local environmental
regulations must be observed. | [Uses]
Esterifying agent for certain perfume oils, fats, oils, and especially cellulose. In the production of alkyd resins, dyestuffs and drugs. Has been used as a dehydrating agent in some sulfonations and nitrations. | [Uses]
Usually used in the preparation of α- and β-1-propionyl derivatives of glucopyranose tetra-acetate. | [Application]
Propionic anhydride was previously used in the preparation of α and β-1-propionyl derivatives of glucopyranose tetra-acetate. | [Flammability and Explosibility]
Nonflammable | [Safety]
Propanoic anhydride is strong smelling and corrosive, and will cause burns on contact with skin. Vapour can burn eyes and lungs. | [Synthesis]
Propanoic anhydride has been prepared by dehydration of propanoic acid using ketene :
2 CH3CH2CO2H + CH2= C= O → (CH3CH2CO)2O + CH3CO2H. | [Purification Methods]
Shake the anhydride with P2O5 for several minutes, then distil. [Beilstein 2 IV 722.] |
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