| Identification | Back Directory | [Name]
BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE SODIUM SALT | [CAS]
1184-16-3 | [Synonyms]
TPN
TPN-NA
INADP-NA
CO II, NA
β-NADP-Na
Co II Na2
BETA-NADP-NA
TPN SODIUM SALT
NADP SODIUM SALT
TPN MONOSODIUM SALT
NADP, MONOSODIUM SALT
BETA-NADP SODIUM SALT
COENZYME II SODIUM SALT
Nicotinamide adenine din
BETA-NADP MONOSODIUM SALT
BETA-NADP SODIUM SALT, HYDRATE
TRIPHOSPHOPYRIDINE NUCLEOTIDE SODIUM SALT
beta-triphosphopyridine nucleotide sodium salt
β-Nicotinamide anenine dinucleotide,trihydrate
-NicotinaMide adenine dinucleotide,phosphate Na2
Hydrate, oxidized forM [for BiocheMical Research]
Nicotinamide adenine dinucleotide sodium phosphate
Nicotinamide adenine dinucleotide phosphate-Na-salt
Beta-Nicotinamideadenine dinucleotidephosphatesodium
NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE SODIUM SALT
beta-Nicotinamide adenine dinucleotide phosphate hydrate
β-Nicotinamide Adenine Dinucleotide Phosphate monosodium
Triphosphopyridine nucleotide, sodiuM salt, hydrate 500MG
b-Nicotinamide adenine dinucleotide phosphate sodium salt
Beta-nicotinamide adenine dinucleotide phosphate(NADP+) Na
BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE SODIUM SALT
β-Nicotinamide adenine dinucleotide phosphate monosodium salt
^b-NicotinaMide adenine dinucleotide phosphate MonosodiuM salt
β-Nicotinamide Adenine Dinucleotide Phosphate Sodium Salt 〔NADP
beta-Nicotinamide adenine dinucleotide phosphate sodium salt (NA
BETA-NICOTINAMIDE-ADENINE DINUCLEOTIDE PHOSPHATE, MONOSODIUM SALT
beta-NicotinaMide Adenine Dinucleotide Phosphate SodiuM Salt
b-Nicotinamide adenine dinucleotide phosphate sodium salt hydrate
beta-Nicotinamide adenine dinudeotide phosphate sodium salt (NADP)
BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE SODIUM SALT, HYDRATE
β-NicotinaMide Adenine Dinucleotide Phosphate SodiuM Salt Hydrate (~90%)
NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (OXIDISED FORM) MONOSODIUM SALT
Beta-nicotinamide adenine dinucleotide phosphate
mono sodium salt
(NADP Na)
beta-Nicotinamide adenine dinucleotide phosphate monosodium salt tetrahydrate
β-Nicotinamide adenine dinucleotide phosphate sodium salt hydrate, oxidized form
Nicotinamide adenine dinucleotide phosphate >98% (oxidised form) monosodium salt
BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE MONOSODIUM SALT (NADP SODIUM SALT)
beta-Nicotinamide adenine dinucleotide phosphate sodium salt
beta-NADP sodium salt
β-NicotinaMide Adenine Dinucleotide Phosphate SodiuM Salt Hydrate, oxidized forM [for BiocheMical Research]
Coenzyme II Sodium Salt
beta-NADP Sodium Salt
TPN Sodium Salt
beta-Triphosphopyridine Nucleotide Sodium Salt
beta-NicotinaMide Adenine Dinucleotide Phosphate SodiuM Salt Hydrate, oxidized forM [for BiocheMical Research]
β-Nicotinamide adenine dinucleotide phosphate sodium salt hydrate,Triphosphopyridine nucleotide sodium salt hydrate
β-NADP-Na, β-NADP-sodium salt, Coenzyme II sodium salt, NADP, TPN-Na, TPN, Triphosphopyridine nucleotide sodium salt
Adenosine 5-(trihydrogen diphosphate), 2-(dihydrogen phosphate), P?5-ester with 3-(aminocarbonyl)-1-.beta.-D-ribofuranosylpyridinium, inner salt, monosodium salt
Adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), 5'→5'-ester with 3-(aminocarbonyl)-1-β-d-ribofuranosylpyridinium hydroxide, inner salt, monosodium salt | [EINECS(EC#)]
214-664-6 | [Molecular Formula]
C21H27N7NaO17P3 | [MDL Number]
MFCD00036973 | [MOL File]
1184-16-3.mol | [Molecular Weight]
765.39 |
| Chemical Properties | Back Directory | [Appearance]
White to slightly yellowish powder | [Melting point ]
175-178 °C (dec.)(lit.)
| [storage temp. ]
−20°C
| [solubility ]
H2O: 50 mg/mL
| [form ]
powder
| [color ]
off-white to yellow
| [PH]
2.0-4.0 | [Water Solubility ]
Soluble in water. | [Merck ]
14,6344 | [BRN ]
4779954 | [InChIKey]
JNUMDLCHLVUHFS-QYZPTAICSA-M |
| Hazard Information | Back Directory | [Chemical Properties]
White to slightly yellowish powder | [Uses]
β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. The NAD | [Description]
Nicotinamide adenine dinucleotide phosphate, abbreviated NADP+ or, in older notation, TPN (triphosphopyridine nucleotide), is a cofactor used in anabolic reactions, such as the Calvin cycle and lipid and nucleic acid syntheses, which require NADPH as a reducing agent ('hydrogen source').It is used by all forms of cellular life. | [Description]
The nicotinamide adenine dinucleotide phosphate oxidase（NADP）is a multicomponent system that transfers an electron to molecular oxygen by way of FAD and heme to form superoxide (O2?) .Cytochrome b558 is a membrane-bound heterodimer lodged in the wall of the secondary granules; the large glycosylated β subunit is gp91phox and the small nonglycosylated α subunit is p22phox.The cytoplasmic tail of gp91phox binds FAD, heme, and NADPH, which are required for electron transfer to oxygen (O2).Neutrophil stimulation leads to aggregation and phosphorylation of p47phox, p67phox, p40phox, and the small guanosine triphosphate (GTP)–binding proteins RAC1/RAC2, which dock with the cytochrome at the membrane through binding of p47phox and p22phox. | [Biosynthesis]
In general, NADP+ is synthesized before NADPH is. Such a reaction usually starts with NAD+ from either the de-novo or the salvage pathway, with NAD+ kinase adding the extra phosphate group. ADP-ribosyl cyclase allows for synthesis from nicotinamide in the salvage pathway, and NADP+ phosphatase can convert NADPH back to NADH to maintain a balance.Some forms of the NAD+ kinase, notably the one in mitochondria, can also accept NADH to turn it directly into NADPH.[3][4] The prokaryotic pathway is less well understood, but with all the similar proteins the process should work in a similar way. | [Biochem/physiol Actions]
Electron acceptor | [Mechanism of action]
NADP sodium salt exerts its effect by competitively inhibiting nucleotide metabolism through the suppression of enzymes like nucleoside diphosphate kinase (NDPK) and adenosine kinase (ADK). Additionally, it serves as a substrate for enzymes like DNA polymerases and RNA polymerases, enabling the integration of NADP monosodium salt into nucleic acids during replication and transcription. |
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