天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook--->CAS DataBase List--->1094-61-7

1094-61-7

1094-61-7 Structure

1094-61-7 Structure
IdentificationBack Directory
[Name]

BETA-NICOTINAMIDE MONONUCLEOTIDE
[CAS]

1094-61-7
[Synonyms]

NMN
β-NMN
β-D-NMN
BETA-NMN
beta-D-NMN
NMN powder
NMN zwitterion
BETA-NMN POWDER
99% NMN CAS 1094 61 7
NICOTINAMIDE RIBOTIDE
Nicotinamide nucleotide
Nicotimide mononucleotide
Nicotinamide mononuclotide
NicotinaMide Ribonucleotide
NICOTINAMIDE MONONUCLEOTIDE
β-Nicotinamide Mononucleotid
β-Nicotinamide ononucleotide
β-Nicotinamide Moonucleotide
B-NICOTINAMIDE MONONUCLEOTIDE
β-Nicotinamide Mononucleotide
beta-Nicotinamide Moonucleotide
β-nicotinamide D-ribonucleotide
β-Nicotinamidse Mononucleotide
[EINECS(EC#)]

214-136-5
[Molecular Formula]

C11H15N2O8P
[MDL Number]

MFCD00038748
[MOL File]

1094-61-7.mol
[Molecular Weight]

334.22
Chemical PropertiesBack Directory
[Definition]

ChEBI: β-Nicotinamide Mononucleotide is a condensation product of nicotinamide and ribose 5-phosphate, in which the nitrogen of nicotinamide is linked to the (β) c-l of the ribose. NMN zwitterion is a nicotinamide mononucleotide. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a conjugate base of a NMN(+). It is a conjugate acid of a NMN(-).
[Melting point ]

166 °C(dec.)
[storage temp. ]

2-8°C
[solubility ]

DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly)
[form ]

Solid
[color ]

White to Yellow
[Merck ]

13,6697
[BRN ]

3570187
[Stability:]

Very Hygroscopic
[InChI]

InChI=1/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8-,9-,11-/s3
[InChIKey]

DAYLJWODMCOQEW-TURQNECASA-N
[SMILES]

O[C@@H]1[C@@H]([C@@H](COP(O)([O-])=O)O[C@H]1[N+]1=CC=CC(C(=O)N)=C1)O |&1:1,2,3,11,r|
Hazard InformationBack Directory
[Chemical Properties]

White Solid
[Uses]

β-Nicotinamide mononucleotide (NMN,1094-61-7) is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments. NMN is a nucleotide derived from ribose and nicotinamide. Niacinamide (nicotinamide,) is a derivative of vitamin B3, also known as niacin.) As a biochemical precursor of NAD+, it may be useful in the prevention of pellagra.
β-Nicotinamide mononucleotide is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to generate β-NMN, which is subsequently converted to NAD+ by β-NMN adenyltransferase.At 50-100 μM, β-NMN has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in a Nampt+/- mouse model of metabolic disease, demonstrating a role for Nampt in β cell function.Furthermore, at 500 mg/kg/day, it has been shown to ameliorate glucose intolerance in high-fat diet-induced type 2 diabetes mice by restoring NAD+ levels.
[Description]

Nicotinamide mononucleotide (NMN,1094-61-7), a product of the NAMPT reaction and a key NAD+ intermediate, ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. NMN also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation. NMN is used for studying binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments.
β-Nicotinamide mononucleotide (β-NMN) is an intermediate in the nicotinamide phosphoribosyltransferase (NAMPT)-catalyzed biosynthesis of nicotinamide adenine dinucleotide (NAD+). NAMPT mediates the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to produce β-NMN. β-NMN adenyltransferase subsequently converts β-NMN to NAD+.
[Application]

β-Nicotinamide mononucleotide (NMN) is a product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice . It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation. It is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments.
[Preparation]

β-Nicotinamide mononucleotide  is  a  NAD+intermediate.  In  recent  years,  the  relation  of  NAD+metabolism  and  aging-associated  disease  is  attracting  attention  from  various  research fields.
Synthesis of β-nicotinamide mononucleotide (NMN)
A solution of NAD (3.5 g, 5.28 mmol) and ZrCl4(6.15 g, 26.4 mmol) in 500 ml water was stirred at 50°C for 30 min. The hydrolysis was monitored by TLC (SiO2EtOH/ 1 M NH4Ac [7 : 3]). The reaction was quenched with 245mL of a 0.5 M solution of Na3PO4. After adjusting to pH 7 with a 2 M solution of HCl, a white precipitate was formed. The suspension was centrifuged 8 min,1,000rpm, the supernatant was collected and the pellet was washed two times with 200 mL water. The combined supernatants wereconcentrated to 1/3 of its volume on a rotary evaporator. The remaining solution was purified with a column filled with Dowex 50WX8 (100-200 mesh, H+-Form, column-material: 2.5 x 30 cm). The column was loaded with 1.5 L5 % HCl and equilibrated with1.5L millipore water until pH 5 was reached. 100 mL of the concentrated solution was loaded on the ion exchange column and eluted with Milliporewater. The first cleavage product eluted was NMN (615 mg, 1.84 mmol,yield:35 %) and yielded a colorless solid after evaporation of the solvent, followed by AMP.
1H NMR (500MHz, D2O)δ: 9.48 (s, 1 H), 9.31 (d,J= 6.2 Hz, 1 H), 9.00 (d,J= 8.2 Hz, 1 H), 8.32 (dd,J= 8.2, 6.2 Hz, 1 H), 6.24 (d,J=5.4 Hz, 1 H), 4.68-4.64 (m, 1 H), 4.58 (t, 1 H), 4.48-4.45 (m, 1 H), 4.36–4.14 (m,J= 12.0, 2 H).
13C NMR (75 MHz, d2o) δ: 165.50, 145.65, 142.15, 139.53, 133.62, 128.19, 99.65, 87.18, 87.06, 77.42, 70.71, 63.89, 63.82.
31P NMR (202 MHz, D2O)δ:-0.03
[General Description]

β-Nicotinamide mononucleotide (β-NMN) is an intermediate in the nicotinamide phosphoribosyltransferase (NAMPT)-catalyzed biosynthesis of nicotinamide adenine dinucleotide (NAD+). NAMPT mediates the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to produce β-NMN. β-NMN adenyltransferase subsequently converts β-NMN to NAD+.
[in vitro]

β-nicotinamide mononucleotide has several beneficial pharmacological activities. Mostly mediated by its involvement in NAD+ biosynthesis, the pharmacological activities of NMN include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity.The intracellular NAD+ levels are significantly decreased by knockdown or knockout of Nampt (Nampt KD or Nampt KO) or treatment with Nampt inhibitor FK866, whereas NAD+ levels are dramatically increased by supplement of NAD+ precursors NAM or NMN (0.5–1 mM). NAD+ precursor NMN treatment inhibited CD8+ T cells activation and function.
[in vivo]

β-Nicotinamide mononucleotide (500 mg/kg; i.p.; 3 times per week for 7-10 week) prevents mtDNA damage and Dox-induced cardiac dysfunction.Nampt KO markedly inhibits tumor progression, whereas Nampt metabolite β-Nicotinamide mononucleotide (300 mg/kg body weight; i.p.; once every two days for 2 weeks) significantly promotes tumor growth in C57BL/6 mice (bearing wildtype Hepa1-6 cells). The reduction and increase in NAD+ level of respective Nampt KO and β-Nicotinamide mononucleotide-treated tumors are confirmed.β-nicotinamide mononucleotide ameliorates glucose intolerance by restoring NAD(+) levels in HFD-induced T2D mice. β-nicotinamide mononucleotide also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.
[Purification Methods]

Purify NMN by passage through a column of Dowex-1 (Clform) and washing with H2O until no absorbance is observed at 260 nm. The tubes containing NMN are pooled, adjusted to pH 5.5-6 and evaporated in vacuo to a small volume. This is adjusted to pH 3 with dilute HNO3 in an ice-bath and treated with 20volumes of Me2CO at 0-5o. The heavy white precipitate is collected by centrifugation at 0o. It is best stored wet and frozen or it can be dried to give a gummy residue. It has max 266nm ( 4,600) and min 249nm ( 3600) at pH 7.0 (i.e. no absorption at 340nm). It can be estimated by reaction with CNor hydrosulfite which form the 4-adducts (equivalent to NADH) which have UV max 340nm ( 6,200). Thus after reaction, an OD340 of one is obtained from a 0.1612mM solution in a 1cm path cuvette. [Plaut & Plaut Biochemical Preparations 5 56 1957, Maplan & Stolzenbach Methods Enzymol 3 899 1957, Kaplan et al. J Am Chem Soc 77 815 1955, Beilstein 22/2 V 168.]
Safety DataBack Directory
[WGK Germany ]

3
[F ]

8-10-21
[HS Code ]

2934999090
Spectrum DetailBack Directory
[Spectrum Detail]

β-Nicotinamide Mononucleotide(1094-61-7)1HNMR
1094-61-7 suppliers list
Company Name: ZhenYiBio Technology Inc
Tel: +8615309206328 , +8615309206328
Website: https://www.zhenyibio.com/
Company Name: Guangzhou TongYi biochemistry technology Co.,LTD
Tel: +8613073028829 , +8613073028829
Website: http://tongyon.com/
Company Name: Sinoway Industrial co., ltd.
Tel: 0592-5800732; +8613806035118 , +8613806035118
Website: https://www.china-sinoway.com/
Company Name: Maintain Biotech Co., Ltd.
Tel: +86-75589664337 +86-15112661142 , +86-15112661142
Website: https://www.maintain-bio.com/en/
Company Name: GIHI CHEMICALS CO.,LIMITED
Tel: +8618058761490 , +8618058761490
Website: https://www.gihichemicals.com/
Company Name: Oxsyns Biotech
Tel: +86-86-18382622232 +8618382622232 , +8618382622232
Website: www.oxsyns.com
Company Name: Strong peptide cross-border e-commerce Co. LTD
Tel: +undefined13930052870 , +undefined13930052870
Website:
Company Name: Hebei Weibang Biotechnology Co., Ltd
Tel: +8615531157085 , +8615531157085
Website: www.weibangbio.com/
Company Name: Hebei Mojin Biotechnology Co., Ltd
Tel: +86 13288715578 +8613288715578 , +8613288715578
Website: http://www.mojinchemical.com
Company Name: Shanghai UCHEM Inc.
Tel: +862156762820 +86-13564624040 , +86-13564624040
Website: http://www.myuchem.com/
Company Name: Dorne Chemical Technology co. LTD
Tel: +86-86-13583358881 +8618560316533 , +8618560316533
Website: www.approvedhomemanagement.com/manufacturer/zibo-dorne-chemical-technology-403/
Company Name: Hebei Yime New Material Technology Co., Ltd.
Tel: +86-66697723 +86-17703311139 , +86-17703311139
Website: http://www.china-yime.com/product.asp
Company Name: Hebei Weibang Biotechnology Co., Ltd
Tel: +8617732866630 , +8617732866630
Website: www.weibangbio.com
Company Name: Hebei Brisk New Material Technology Co. , Ltd.
Tel: +8613393045540 , +8613393045540
Website: www.approvedhomemanagement.com/showsupplierproductslist1260652/0.htm
Company Name: Anhui Yiao New Material Technology Co., Ltd
Tel: +86-18033737140 +86-17354101231 , +86-17354101231
Website: www.approvedhomemanagement.com/manufacturer/yiao%20new%20material%20technology%20-25052/
Company Name: Suzhou Sanyi Polymer Chemical Technology Co., Ltd.
Tel: +8615571922873 , +8615571922873
Website: www.approvedhomemanagement.com/showsupplierproductslist988872/0.htm
Company Name: Hebei Kingfiner Technology Development Co.Ltd
Tel: +86-15532196582 +86-15373005021 , +86-15373005021
Website: https://www.kingfinertech.com
Company Name: Hangzhou ICH Biofarm Co., Ltd
Tel: +86-0571-28186870; +undefined8613073685410 , +undefined8613073685410
Website: http://www.ichemie.com/
Tags:1094-61-7 Related Product Information
87-89-8 100-54-9 1453-82-3 1986-81-8 1452-77-3 59-67-6 1341-23-7 23111-00-4 98-92-0 606-68-8 56-12-2 321-02-8 10212-25-6 108347-85-9 439685-79-7 425642-32-6 350685-86-8