| Identification | More | [Name]
2'-Hydroxyacetophenone | [CAS]
118-93-4 | [Synonyms]
1-(2-HYDROXYPHENYL)ETHANONE
2-ACETOPHENOL
2-ACETYLPHENOL
2'-HYDROXYACETOPHENONE
2-HYDROXYACETOPHENONE
2-HYDROXYPHENYL METHYL KETONE
AKOS 90575
AKOS BBS-00003239
FEMA 3548
O-ACETOPHENOL
O-HYDROXYACETOPHENONE
1-(2-hydroxyphenyl)-ethanon
2’-hydroxy-acetophenon
2-hydroxyacetylbenzene
Acetophenone, o-hydroxy-
Ethanone,1-(2-hydroxyphenyl)-
o-Acetylphenol
o-hydroxy-acetophenon
o-Hydroxyphenyl methyl ketone
o-hydroxyphenylmethylketone | [EINECS(EC#)]
204-288-0 | [Molecular Formula]
C8H8O2 | [MDL Number]
MFCD00002219 | [Molecular Weight]
136.15 | [MOL File]
118-93-4.mol |
| Chemical Properties | Back Directory | [Appearance]
clear yellow to brown liquid | [Melting point ]
3-6 °C(lit.)
| [Boiling point ]
213 °C717 mm Hg(lit.)
| [density ]
1.131 g/mL at 25 °C(lit.)
| [vapor density ]
4.7 (vs air)
| [vapor pressure ]
~0.2 mm Hg ( 20 °C)
| [FEMA ]
3548 | [refractive index ]
n20/D 1.558(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Store below +30°C. | [solubility ]
0.2g/l | [form ]
Liquid | [pka]
10.06(at 25℃) | [color ]
Clear yellow to brown | [Odor]
at 10.00 % in dipropylene glycol. phenolic sweet hawthorn tobacco honey herbal | [explosive limit]
0.98-11.8%(V) | [Odor Type]
phenolic | [Water Solubility ]
slightly soluble | [Detection Methods]
GC | [JECFA Number]
727 | [BRN ]
386123 | [LogP]
1.92-1.97 at 25℃ | [Dissociation constant]
10.06-10.25 at 20-25℃ | [CAS DataBase Reference]
118-93-4(CAS DataBase Reference) | [NIST Chemistry Reference]
Ethanone, 1-(2-hydroxyphenyl)-(118-93-4) | [EPA Substance Registry System]
118-93-4(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R36/38:Irritating to eyes and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [RTECS ]
AM8575000
| [F ]
8 | [Hazard Note ]
Harmful/Irritant | [TSCA ]
Yes | [HS Code ]
29145000 | [Toxicity]
LD50 orally in Rabbit: 2127 mg/kg LD50 dermal Rat > 2000 mg/kg |
| Questions And Answer | Back Directory | [Description]
2'-Hydroxyacetophenone is a flavouring ingredient. It is a typical flavour additive for cherry kernel, cinnamon, rum, tobacco, coumarin, and tropical fruit. Moreover, it can be used as the intermediate or raw material in organic synthesis. Specifically, this chemical may act as the raw material to prepare a Schiff's base al-alkoxide initiator that facilitates the controlled polymerization of DL-lactide.1 This substance can also function as the effective component in balsamic compounds for fabricating taste modifying compositions.2 Additionally, this chemical has been employed to react with benzoyl chloride for generating 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran, which exhibits good performance for treating cancer and other proliferative diseases such as psoriasis and restenosis.3 | [Reference]
- Bhaw-Luximon, A.; Jhurry, D.; Spassky, N., Controlled polymerization of DL-lactide using a Schiff's base al-alkoxide initiator derived from 2-hydroxyacetophenone. Polym. Bull. 2000, 44, 31-38.
- Johann Wonschick; Clemens M. Putter; Keepe, E., TASTE MODIFYING COMPOSITIONS PCT WO 2016/103183 A1 2016.
- Alexander J Bridges; Saltiel, A. R., 2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders US Patent US5525625 1996.
|
| Hazard Information | Back Directory | [Chemical Properties]
2-Hydroxyacetophenone has a sweet, heavy floral, herbaceous odor, reminiscent of mown hay or hawthorn | [Chemical Properties]
clear yellow to brown liquid | [Occurrence]
Reported found in beef, cassia oil, cocoa, cocoa powder, coffee, Jamaican rum, tomato, Scotch whiskey, sherry,
tea, mountain papaya, papaya, roasted almond and black choke berry | [Uses]
2’Hydroxyacetophenone is a phenolic compound used in the synthesis of potential anti-myobacterial and anticancer agents. | [Definition]
ChEBI: 2'-Hydroxyacetophenone is a monohydroxyacetophenone that is acetophenone in which one of the hydrogens ortho to the acetyl group has been replaced by a hydroxy group. It has a role as a flavouring agent. It is a monohydroxyacetophenone and a member of phenols. | [Preparation]
Preparation by Fries rearrangement of phenyl acetate, with Lewis acids
aluminium chloride. | [Aroma threshold values]
Detection: 5.5 ppm; aroma characteristics at 2.0%: phenolic, sharp, benzaldehyde, cherry pit, tropical,
melon with a tobacco afternote | [Taste threshold values]
Taste characteristics at 5.0 ppm: naphthyl, cinnamon, cherry pit, coumarin, phenolic, tobacco and honey. | [Synthesis Reference(s)]
Tetrahedron Letters, 24, p. 377, 1983 DOI: 10.1016/S0040-4039(00)81412-4 | [General Description]
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards |
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