| Identification | More | [Name]
3-HYDROXY-3-METHYL-2-BUTANONE | [CAS]
115-22-0 | [Synonyms]
3-HYDROXY-3-METHYL-2-BUTANONE
ACETYLDIMETHYLCARBINOL
1-Hydroxy-1-methylethyl methyl ketone
2-Butanone, 3-hydroxy-3-methyl-
2-Hydroxy-2-methyl-3-butanone
2-Methyl-2-hydroxybutan-3-one
3-hydroxy-3-methyl-2-butanon
3-Hydroxy-3-methylbutanone
3-Methylacetoin
Dimethylacetylcarbinol
Methylacetoin
3-hydroxy-3-ethylbutanone
3-HYDROXY-3-METHYL-2-BUTANONE 90+%
2-Methylbutan-2-ol-3-one | [EINECS(EC#)]
204-073-1 | [Molecular Formula]
C5H10O2 | [MDL Number]
MFCD00004460 | [Molecular Weight]
102.13 | [MOL File]
115-22-0.mol |
| Chemical Properties | Back Directory | [Appearance]
CLEAR COLOURLESS TO LIGHT YELLOW LIQUID | [Melting point ]
84-85 °C | [Boiling point ]
140-141 °C (lit.) | [density ]
0.971 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.415(lit.)
| [Fp ]
108 °F
| [storage temp. ]
Flammables area | [solubility ]
Soluble in chloroform. | [form ]
Liquid | [pka]
13.28±0.29(Predicted) | [color ]
Clear colorless to yellow or light red | [BRN ]
1616385 | [InChIKey]
BNDRWEVUODOUDW-UHFFFAOYSA-N | [LogP]
0.112 (est) | [Uses]
Intermediate. | [CAS DataBase Reference]
115-22-0(CAS DataBase Reference) | [EPA Substance Registry System]
2-Butanone, 3-hydroxy-3-methyl- (115-22-0) |
| Safety Data | Back Directory | [Risk Statements ]
R10:Flammable. | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S24/25:Avoid contact with skin and eyes . | [RIDADR ]
UN 1224 3/PG 3
| [WGK Germany ]
3
| [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29144000 |
| Hazard Information | Back Directory | [Chemical Properties]
CLEAR COLOURLESS TO LIGHT YELLOW LIQUID | [Application]
3-Hydroxy-3-methyl-2-butanone is an alpha-hydroxy ketone compound. It can be used as a biologically active natural product and a pharmaceutical intermediate, and as a photoinitiator in UV-curable coatings. At the same time, α-hydroxyketone structural units are also widely used synthons in organic synthesis. Hydroxyl can be used as a mild reaction precursor for double bonds, ester groups, carbonyl groups, halogenated hydrocarbons and other groups. Carbonyl can be used as the reaction precursor of hydroxyl, amino, alkyl and other groups. Therefore, α-hydroxyketone compounds are a class of compounds with important application value. | [Definition]
ChEBI:3-Hydroxy-3-methylbutan-2-one is a secondary alpha-hydroxy ketone. | [Preparation]
synthesis of 3-Hydroxy-3-methyl-2-butanone: 19ml of concentrated sulfuric acid (98wt%) was slowly mixed with 100ml of water, then 13g of yellow mercury oxide was added within 1.5h, 84g (1.0mol) of 2-methyl-3-butyn-2-ol was added dropwise to the sulfuric acid solution containing mercury oxide at 65-75°C, Then the reaction was stirred at 65-75°C for 30min, cooled to room temperature after the reaction was completed, the reaction product was subjected to suction filtration, the filtrate after suction filtration was extracted with ether (3×20ml), and the organic phase after extraction was water and hydrogen carbonate respectively. Washed with sodium solution, the washed organic phase was dried with anhydrous magnesium sulfate, and then filtered, the filtered filtrate was concentrated by rotary evaporation and then distilled, and the 140°C fraction was collected, 45.6 g of light yellow liquid was obtained as 3-hydroxy-3-methyl-2-butanone, and the yield was 32.2%. |
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