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ChemicalBook--->CAS DataBase List--->1177-87-3

1177-87-3

1177-87-3 Structure

1177-87-3 Structure
IdentificationMore
[Name]

Dexamethasone-17-acetate
[CAS]

1177-87-3
[Synonyms]

1,4-PREGNADIEN-9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-ACETATE
9a-fluoro-16a-methyl-11b,17a,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate
9 ALPHA-FLUORO-11 BETA,17 ALPHA,21-TRIHYDRO-16 ALPHA-METHYLPREGNA-1,4-DIENE-3,20-DIONE-21-ACETATE
9ALPHA-FLUORO-16ALPHA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE-21-ACETATE
9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA,17-ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE ACETATE
9ALPHA-FLUORO-16ALPHA-METHYLPREDNISOLONE-21-ACETATE
DEXAMETHASON ACETATE
dexamethasone-17-acetate
DEXAMETHASONE 21-ACETATE
DEXAMETHASONE ACETATE
PREDNISOLONE F ACETATE
,(11beta,16alpha)-
16alpha-Methyl-9alpha-fluoroprednisolone 21-acetate
20-dione,21-(acetyloxy)-9-fluoro-11,17-dihydroxy-16-methyl-pregna-4-diene-3
20-dione,9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methyl-pregna-4-diene-3
9alpha-Fluoro-16alpha-methylprednisolone acetate
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione21-acetate
9-Fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl acetate
9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-acetate
[EINECS(EC#)]

214-646-8
[Molecular Formula]

C24H31FO6
[MDL Number]

MFCD00027407
[Molecular Weight]

434.5
[MOL File]

1177-87-3.mol
Chemical PropertiesBack Directory
[Melting point ]

238-240 °C(lit.)
[alpha ]

D25 +73° (chloroform) (Arth, 1958); D +77.6° (Oliveto)
[Boiling point ]

579.4±50.0 °C(Predicted)
[density ]

1.1517 (estimate)
[refractive index ]

87 ° (C=1, Dioxane)
[storage temp. ]

2-8°C
[solubility ]

Soluble at 100 mg/ml in acetone
[form ]

Powder
[pka]

12.08±0.70(Predicted)
[color ]

White
[Water Solubility ]

13mg/L(25 ºC)
[Merck ]

2943
[BRN ]

2342608
[CAS DataBase Reference]

1177-87-3(CAS DataBase Reference)
[NIST Chemistry Reference]

Prednisolone, 9alpha-fluoro-16alpha-methyl-, acetate(1177-87-3)
[EPA Substance Registry System]

1177-87-3(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

R43:May cause sensitization by skin contact.
[Safety Statements ]

S36/37:Wear suitable protective clothing and gloves .
[WGK Germany ]

3
[RTECS ]

TU4050000
[TSCA ]

Yes
[HS Code ]

29372290
[Safety Profile]

Experimental teratogenic and reproductive effects. A steroid. When heated to decomposition it emits toxic fumes of F-.
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Hydrogen fluoride-->Ethylene glycol-->Methyl bromide-->Progesterone-->11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
[Preparation Products]

9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione21-phosphate piperazine salt-->Dexamethasone
Hazard InformationBack Directory
[Chemical Properties]

Off-White Solid
[Originator]

Dexacen,Central,US,1977
[Uses]

Protected Dexamethasone, a glucocorticoid anti-inflammatory agent.
[Definition]

ChEBI: Dexamethasone acetate is a corticosteroid hormone.
[Manufacturing Process]

The preparation of dexamethasone acetate is described in US Patent 3,007,923 as follows. 1.5 cc of dimethylformamide and 1.5 cc of anhydrous hydrofluoric acid are admixed and treated with 480 mg of 9β,11β-epoxy-17αhydroxy-21-acetoxy-16α-methyl-?1,4-pregnadiene-3,20-dione (prepared according to E.P. Oliveto et al, J. Am. Chem. Soc., 80, 44331, 1958). The steroid dissolves in about 15 minutes. The reaction mixture is shaken for two hours at a temperature between 0 and +5°C, and then poured into 75 cc of
water containing in suspension, 7.5 grams of sodium bicarbonate. The mixture is vacuum filtered, the filter cake washed and then dried at 100°C, yielding 460 mg of crude hexadecadrol contaminated with a small amount of the starting material. A single recrystallization from methylene chloride yields 370 mg of the pure product having a melting point of 170°C and 229°C. The mother liquor yields 62 mg of the starting material, and a remainder constituting a mixture of starting and final materials with little other contamination.
[Brand name]

Decadron (Merck).
[Therapeutic Function]

9-Fluoro-11β,17-dihydroxy-21-acetoxy-16α-methylpregna1,4-diene-3,20-dione
[Purification Methods]

Dexamethasone 21-acetate is purified on neutral Al2O3 using CHCl3 as eluent, the fractions are evaporated, and the residue is recrystallised from CHCl3. It has max at 239nm. [Oliveto et al. J Am Chem Soc 8 0 4431 1958]. [Beilstein 8 IV 3501.]
Spectrum DetailBack Directory
[Spectrum Detail]

Dexamethasone-17-acetate(1177-87-3)MS
Dexamethasone-17-acetate(1177-87-3)1HNMR
Dexamethasone-17-acetate(1177-87-3)13CNMR
Dexamethasone-17-acetate(1177-87-3)IR1
Dexamethasone-17-acetate(1177-87-3)IR2
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

1177-87-3(sigmaaldrich)
[TCI AMERICA]

Dexamethasone 21-Acetate,>98.0%(LC)(1177-87-3)
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